A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition

Abstract

In this work, Arg-Gly-Asp (RGD) peptide-coupled polydopamine-modified mesoporous platinum nanoparticles (mPt@PDA-RGD NPs) were developed for targeted photothermal therapy (PTT) and migration inhibition of SKOV-3 cells. mPt@PDA-RGD NPs with obvious core/shell structure demonstrated high photothermal performance under 808-nm near-infrared (NIR) laser irradiation. mPt@PDA-RGD NPs with favorable biocompatibility exhibited remarkable SKOV-3 inhibition ability under NIR laser irradiation. Moreover, compared to mPt@PDA NPs, the RGD-functionalized NPs achieved more tumor uptake and PTT performance, which was attributed to the specific interaction between RGD of NPs and αvβ3 integrin overexpressed by SKOV-3. Importantly, cell scratch experiments indicated that the photothermal effect of mPt@PDA-RGD NPs can effectively inhibit the migration of surviving SKOV-3 cells, which was assigned to disturbance of the actin cytoskeleton of SKOV-3. Thus, mPt@PDA-RGD NPs presented great potential for targeted tumor photothermal ablation and migration inhibition.

Tumor-targeted molybdenum disulfide@barium titanate core–shell nanomedicine for dual photothermal and chemotherapy of triple-negative breast cancer cells

“…There was an increase in heat generation by MBPF due to the PDA coating, which increased the ability to absorb photons more efficiently compared to MoS 2 @BT. 68,69 Linear fitting of the MBPF sample solution showed an excellent linear relationship with an R-squared value of 0.9948, as shown in Fig. S7 (ESI †).…”

Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics

“…Based on this property, Di et al [ 76 ] designed a highly viscous, reusable, and heat-reversible hydrogel for the preparation of wound dressings, electronic skin, and wearable devices. In addition, PDA also has excellent photothermal properties, which can destroy the structure and function of cancer cells and microorganisms through photothermal therapy (PTT) to effectively treat cancer and microbial infection [ 77 , 78 ]. Therefore, PDA-based hydrogels can be loaded with antibacterial agents or combined with PTT to achieve high antibacterial efficiency.…”

Research progress of inorganic metal nanomaterials in biological imaging and photothermal therapy

“…因此, TPP-Pt以肿瘤细胞的 线粒体为靶点进行光热治疗, 显示出优异的肿瘤抑制 效果, 减轻了对正常细胞的损伤, 从而显著增强光热 治疗效果. Zou等 [154] 使用PDA修饰介孔Pt NPs, 然后与 RGD肽偶联, 得到具有明显核壳结构的mPt@PDA-RGD NPs材料. 其中, PDA外表面含有大量的邻苯二 酚和氨基, 有利于肿瘤细胞特异性配体对纳米材料的 功能化并提高生物相容性 [155] ; RGD可以增强肿瘤对 纳米材料的摄取, 提高PTT的治疗效果 [156] .…”