Abstract:We investigate a version of Viro's method for constructing polynomial systems with many positive solutions, based on regular triangulations of the Newton polytope of the system. The number of positive solutions obtained with our method is governed by the size of the largest positively decorable subcomplex of the triangulation. Here, positive decorability is a property that we introduce and which is dual to being a subcomplex of some regular triangulation. Using this duality, we produce large positively decorab… Show more
“…(0, 14), (0, 24), (1,24), (2,13), (2,14), (3,14), (3, 024), (02, 3), (02, 4), (03, 1), (03, 2), (13,2), (13,4), then after rescaling of the k on 's and on 's the distributive sequential 5-site phosphorylation system has at least 5 steady states.…”
Section: Computer Aided Resultsmentioning
confidence: 99%
“…We developed in this paper both the theoretical setting based on [1,2] and the algorithmic approach that follows from it, to describe multistationarity regions in the space of all parameters for subnetworks of the n-site sequential phosphorylation cycle, where there are up to 2[ n 2 ] + 1 positive steady states with fixed linear conservation constants. We chose to assume that the subnetworks we consider have intermediate species only in the E component, but of course there is a symmetry in the network interchanging E with F , each S i with S n−i , the corresponding intermediates and rate constants, and completely similar results hold if we assume that there are only intermediates in the F component.…”
Section: Discussionmentioning
confidence: 99%
“…As we saw in Subsection 2.1, the steady states of the systems G J correspond to the positive solutions of the sparse polynomial system (2.4) in two variables. In this section, we briefly recall the general setting from [1,2] to find lower bounds for sparse polynomial systems, that we will use in the proof of Theorems 1.2 and 1.4 in Section 4 and also in Section 5. For detailed examples of this approach, we refer the reader to Section 2 in [14].…”
Section: Positive Solutions Of Sparse Polynomial Systemsmentioning
confidence: 99%
“…, f d . Our method to obtain a lower bound on the number of positive steady states, based on [1,2], is to restrict our polynomial system (3.1) to subsystems which have a positive solution and then extend these solutions to the total system, via a deformation of the coefficients. The first step is then to find conditions in the coefficient matrix C that guarantee a positive solution to each of the subsystems.…”
Section: Positive Solutions Of Sparse Polynomial Systemsmentioning
The distributive sequential n-site phosphorylation/dephosphorylation system is an important building block in networks of chemical reactions arising in molecular biology, which has been intensively studied. In the nice paper of Wang and Sontag (2008) it is shown that for certain choices of the reaction rate constants and total conservation constants, the system can have 2[ n 2 ] + 1 positive steady states (that is, n + 1 positive steady states for n even and n positive steady states for n odd). In this paper we give open parameter regions in the space of reaction rate constants and total conservation constants that ensure these number of positive steady states, while assuming in the modeling that roughly only 1 4 of the intermediates occur in the reaction mechanism. This result is based on the general framework developed by Bihan, Dickenstein, and Giaroli (2018), which can be applied to other networks. We also describe how to implement these tools to search for multistationarity regions in a computer algebra system and present some computer aided results.
“…(0, 14), (0, 24), (1,24), (2,13), (2,14), (3,14), (3, 024), (02, 3), (02, 4), (03, 1), (03, 2), (13,2), (13,4), then after rescaling of the k on 's and on 's the distributive sequential 5-site phosphorylation system has at least 5 steady states.…”
Section: Computer Aided Resultsmentioning
confidence: 99%
“…We developed in this paper both the theoretical setting based on [1,2] and the algorithmic approach that follows from it, to describe multistationarity regions in the space of all parameters for subnetworks of the n-site sequential phosphorylation cycle, where there are up to 2[ n 2 ] + 1 positive steady states with fixed linear conservation constants. We chose to assume that the subnetworks we consider have intermediate species only in the E component, but of course there is a symmetry in the network interchanging E with F , each S i with S n−i , the corresponding intermediates and rate constants, and completely similar results hold if we assume that there are only intermediates in the F component.…”
Section: Discussionmentioning
confidence: 99%
“…As we saw in Subsection 2.1, the steady states of the systems G J correspond to the positive solutions of the sparse polynomial system (2.4) in two variables. In this section, we briefly recall the general setting from [1,2] to find lower bounds for sparse polynomial systems, that we will use in the proof of Theorems 1.2 and 1.4 in Section 4 and also in Section 5. For detailed examples of this approach, we refer the reader to Section 2 in [14].…”
Section: Positive Solutions Of Sparse Polynomial Systemsmentioning
confidence: 99%
“…, f d . Our method to obtain a lower bound on the number of positive steady states, based on [1,2], is to restrict our polynomial system (3.1) to subsystems which have a positive solution and then extend these solutions to the total system, via a deformation of the coefficients. The first step is then to find conditions in the coefficient matrix C that guarantee a positive solution to each of the subsystems.…”
Section: Positive Solutions Of Sparse Polynomial Systemsmentioning
The distributive sequential n-site phosphorylation/dephosphorylation system is an important building block in networks of chemical reactions arising in molecular biology, which has been intensively studied. In the nice paper of Wang and Sontag (2008) it is shown that for certain choices of the reaction rate constants and total conservation constants, the system can have 2[ n 2 ] + 1 positive steady states (that is, n + 1 positive steady states for n even and n positive steady states for n odd). In this paper we give open parameter regions in the space of reaction rate constants and total conservation constants that ensure these number of positive steady states, while assuming in the modeling that roughly only 1 4 of the intermediates occur in the reaction mechanism. This result is based on the general framework developed by Bihan, Dickenstein, and Giaroli (2018), which can be applied to other networks. We also describe how to implement these tools to search for multistationarity regions in a computer algebra system and present some computer aided results.
“…This question is related to more general open problems in real algebraic geometry concerning possible gaps between the number of complex and real solutions of an algebraic system depending on its parameters. There exist some upper [29] and lower [3,4] bounds on the number of real positive roots, which take advantage of the structure of polynomials. Regarding applied cases, there is also the famous example on the maximization of the number of real Stewart-Gough Platform configurations [11], using a gradient descent method.…”
Rigidity theory studies the properties of graphs that can have rigid embeddings in a euclidean space R d or on a sphere and which in addition satisfy certain edge length constraints. One of the major open problems in this field is to determine lower and upper bounds on the number of realizations with respect to a given number of vertices. This problem is closely related to the classification of rigid graphs according to their maximal number of real embeddings.In this paper, we are interested in finding edge lengths that can maximize the number of real embeddings of minimally rigid graphs in the plane, space, and on the sphere. We use algebraic formulations to provide upper bounds. To find values of the parameters that lead to graphs with a large number of real realizations, possibly attaining the (algebraic) upper bounds, we use some standard heuristics and we also develop a new method inspired by coupler curves. We apply this new method to obtain embeddings in R 3 . One of its main novelties is that it allows us to sample efficiently from a larger number of parameters by selecting only a subset of them at each iteration.Our results include a full classification of the 7-vertex graphs according to their maximal numbers of real embeddings in the cases of the embeddings in R 2 and R 3 , while in the case of S 2 we achieve this classification for all 6-vertex graphs. Additionally, by increasing the number of embeddings of selected graphs, we improve the previously known asymptotic lower bound on the maximum number of realizations. The methods and the results concerning the spatial embeddings are part of the proceedings of ISSAC 2018 [[1]].
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.