A Polymer-Based Microfluidic Platform Featuring On-Chip Actuated Hydrogel Valves for Disposable Applications

Geiger, Emil J.; Pisano, Albert P.; Švec, František

doi:10.1109/jmems.2010.2048702

Cited by 22 publications

(23 citation statements)

References 55 publications

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“…In both cases, when the heat supplied to the systems reached a temperature at or above the LCST of p(NIPAAm), the polymer matrix contracted in volume, and the off-chip and on-chip opening times were ~3 s. Off-chip reclosing of the channel took ~20 s compared to ~5 s for on-chip reclosing . The results demonstrate that incorporation of micro-heaters into the microfluidic device can enable fast actuation and successful repeatability when compared to the manual off-chip method [33]. Recently this ability to use thermo-responsive hydrogels in autonomous microfluidic systems with little or no human intervention has been further improved through the work of Agarwal et al, [53] through their work on "autonomously-triggered on-chip microfluidic cooling devices".…”

Section: Thermo-induced Actuationmentioning

confidence: 95%

“…Due to the hydrophilic character of hydrogels, strong associative interactions between polymer chains and water molecules occur, resulting in a high degree of water absorption (up to 95% of total mass) [13,33]. As the swelling of the hydrogel is a diffusion-controlled process, the microfluidic systems provide an ideal platform to demonstrate hydrogel functionality, as the micro/nanoscale dimensions considerably reduce water the diffusion pathlengths, thereby improving actuation kinetics that in some cases can reduce hydrogel response time from hours to seconds [34,35].…”

Section: Soft Actuators -Hydrogelsmentioning

confidence: 99%

“…[52] One important advance in this field is the in-situ polymerisation of hydrogels within microfluidic devices. In the work by Giger et al [33], a p(NIPAAm) based polymer matrix was photopolymerised using UV-light within an injection-molded channel. The thermal response was investigated for both on and off-chip actuation.…”

Section: Thermo-induced Actuationmentioning

confidence: 99%

See 2 more Smart Citations

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

Dunne¹,

Francis²,

Delaney³

et al. 2017

Reference Module in Materials Science and Materials Engineering

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Integration of stimuli-responsive materials into microfluidic systems provides a means to locally manipulate flow at the microscale, in a non-invasive manner, while also reducing system complexity. In recent years, several modes of stimulation have been applied, including electrical, magnetic, light and temperature, among others. To achieve remote control of flow in microfluidics using external stimulation, two main approaches have emerged in the recent years: 1. Control of flow through stimuli-induced actuation of microfluidic components (valves, pumps, mixers, flow sorters), most often fabricated from soft polymeric materials; 2. Stimuli-controlled manipulation of discrete micrometer-sized "vehicles" (droplets, beads, Janus particles, etc.) through localized induced changes in wettability or surface tension.The focus of this chapter will be to identify and compare the similarities and underlying mechanisms employed in the current state of the art research in stimuli-controlled fluid control and micro-vehicle movement fields. It will also endeavor to propose possible directions for the evolution of these areas of research.

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Section: Thermo-induced Actuationmentioning

confidence: 95%

Section: Soft Actuators -Hydrogelsmentioning

confidence: 99%

See 1 more Smart Citation

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

Dunne¹,

Francis²,

Delaney³

et al. 2017

Reference Module in Materials Science and Materials Engineering

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“…Based on the maximum operating parameters (flow rate and back pressure), they concluded that the diffusion type is well suited to low-performance applications, whereas the displacement type is better suited to medium-or high-performance applications. The same actuation principle-integrated resistive heaters and thermally responsive PNIPAAm in a microfluidic channel-was also used to realize valves that are normally closed at room temperature [130]. Upon heating above the lower Fig.…”

Section: Temperature-sensitive Phsmentioning

confidence: 99%

Stimulus-active polymer actuators for next-generation microfluidic devices

Hilber

2016

Appl. Phys. A

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Microfluidic devices have not yet evolved into commercial off-the-shelf products. Although highly integrated microfluidic structures, also known as lab-on-a-chip (LOC) and micrototal-analysis-system (lTAS) devices, have consistently been predicted to revolutionize biomedical assays and chemical synthesis, they have not entered the market as expected. Studies have identified a lack of standardization and integration as the main obstacles to commercial breakthrough. Soft microfluidics, the utilization of a broad spectrum of soft materials (i.e., polymers) for realization of microfluidic components, will make a significant contribution to the proclaimed growth of the LOC market. Recent advances in polymer science developing novel stimulus-active soft-matter materials may further increase the popularity and spreading of soft microfluidics. Stimulus-active polymers and composite materials change shape or exert mechanical force on surrounding fluids in response to electric, magnetic, light, thermal, or water/solvent stimuli. Specifically devised actuators based on these materials may have the potential to facilitate integration significantly and hence increase the operational advantage for the end-user while retaining costeffectiveness and ease of fabrication. This review gives an overview of available actuation concepts that are based on functional polymers and points out promising concepts and trends that may have the potential to promote the commercial success of microfluidics.

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“…Upon heating above the lower critical solution temperature (LCST) of 32°C, the polymer valve became hydrophobic, shrank and formed large pores, thus allowing the solution to flow. (Geiger et al, 2010) Chunder et al developed a superhydrophobic/hydrophilic switchable surface through the combination of layer-by-layer self-assembly and microfabrication techniques. This smart surface realized in a microfluidic channel could therefore act as thermosensitive valve able to control fluid flow by changing the temperature.…”

Section: Microvalvesmentioning

confidence: 99%

Smart Microfluidics: The Role of Stimuli- Responsive Polymers in Microfluidic Devices

Argentiere¹,

Gigli²,

Gerges³

et al. 2012

Advances in Microfluidics

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A Polymer-Based Microfluidic Platform Featuring On-Chip Actuated Hydrogel Valves for Disposable Applications

Cited by 22 publications

References 55 publications

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

Stimulus-active polymer actuators for next-generation microfluidic devices

Smart Microfluidics: The Role of Stimuli- Responsive Polymers in Microfluidic Devices

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