A polymer‑calcium phosphate nanocapsule for RNAi-induced oxidative stress and cascaded chemotherapy

Huang, Jinsheng; Zheng, Chujie; Xiao, Hong; Huang, Huiling; Wang, Yiyao; Lin, Minzhao; Pang, Jun; Wang, Yong; Yuan, Yuanyuan; Shuai, Xintao

doi:10.1016/j.jconrel.2021.10.030

Cited by 17 publications

(11 citation statements)

References 59 publications

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“…[10][11][12][13][14][15][16] For nanomedicine development, it is inevitable to choose a suitable nanomaterial as a platform. Various nanomaterials including organic nanomaterials such as liposomes, micelles, dendrimers, polymers, etc., [17][18][19][20][21][22] and inorganic nanomaterials such as ultrasmall iron oxide (Fe 3 O 4 ), gold, silica (SiO 2 ), layered double hydroxide (LDH), laponite ® (LAP) nanoparticles (NPs), etc. 5,[23][24][25] have been extensively explored.…”

Section: Introductionmentioning

confidence: 99%

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LAPONITE® nanodisk-based platforms for cancer diagnosis and therapy

Guo

et al. 2022

Mater. Adv.

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Section: Introductionmentioning

confidence: 99%

“…Various nanomaterials including organic nanomaterials such as liposomes, micelles, dendrimers, polymers, etc. 17–22 and inorganic nanomaterials such as ultrasmall iron oxide (Fe 3 O 4 ), gold, silica (SiO 2 ), layered double hydroxide (LDH), LAPONITE® (LAP) nanoparticles (NPs), etc. 5,23–25 have been extensively explored.…”

Section: Introductionmentioning

confidence: 99%

LAPONITE® nanodisk-based platforms for cancer diagnosis and therapy

Guo

et al. 2022

Mater. Adv.

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“…Preparation of Nanoparticles. PTX NPs were prepared by ultrasonic emulsification and self-assembly of DSPE-PEG 2K , which was amphiphilic block copolymers [29,30]. In brief, DSPE-PEG 2K was dissolved in trichloromethane with PTX; then, water was added to get mixture via ultrasound.…”

Section: Methodsmentioning

confidence: 99%

“…At last, buffer solution (pH 7.4) containing 140 mM NaCl, 50 mM HEPES, and 15 mM Na 2 HPO 4 was added into the mixture, which was stirred for 30 min. Then, CaP-PTX/siA-DAM10 NPs were purified by ultracentrifugation [29].…”

Section: Methodsmentioning

confidence: 99%

Calcium Phosphorus Nanoparticles Coloaded with Paclitaxel and ADAM‐10‐siRNA for the Treatment of Triple Negative Breast Cancer

Sun

2022

Journal of Nanomaterials

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It is urgent to develop nonside effects and targeting and effective therapeutic agents for triple negative breast cancer (TNBC). Herein, first-line chemotherapeutic drug paclitaxel (PTX) and a disintegrin and metalloproteinase 10 (ADAM10) small interfering RNA (siRNA) were simultaneously encapsulated in shell-core-distinct nanoparticles to enhance tumor suppressive effect. Specifically, copolymer DSPE-PEG2K packed with PTX to form the hydrophobic core, while CaP shell coating siADAM10 to form the hydrophilic shell. The PEG chains in the outer layer of the nanoparticles prevent the immune system from engulfing them and thus increase their systemic circulation time. CaP-PTX/siADAM10 NPs could target tumor site through the enhanced permeability and retention (EPR) effect. The siADAM10 in outer shell is first released to exert its gene inhibitory effect to increase the sensitivity of tumor cells to chemotherapeutic drugs, and then, the inner PTX is released from the CaP-PTX/siADAM10 NPs to exert its tumor-killing effect. The codelivery system of chemotherapeutic agent and siRNA in a core-shell nanoparticle provided a potent effective cancer therapy.

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“…Small interfering RNA (siRNA) molecules have been extensively explored to treat many diseases including cancer and liver diseases due to their highly efficient target gene silencing. [ 1–4 ] siRNA delivery efficiency has been greatly improved through several strategies including targeting ligand modification, [ 5–8 ] size engineering, [ 9,10 ] tunable surface charge, [ 11–13 ] and sheddable polyethylene glycol (PEG) strategies, [ 14–16 ] which substantially enhance siRNA therapy effect. However, non‐specific gene inhibition in normal tissues remains a limitation for siRNA therapy, which is due to the uncontrolled distribution of siRNA in vivo.…”

Section: Introductionmentioning

confidence: 99%

Unprotonatable and ROS‐Sensitive Nanocarrier for NIR Spatially Activated siRNA Therapy with Synergistic Drug Effect

Deng

Wang

Xiao

et al. 2022

Small

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Although small interfering RNA (siRNA) therapy has achieved great progress, unwanted gene inhibition in normal tissues severely limits its extensive clinical applications due to uncontrolled siRNA biodistribution. Herein, a spatially controlled siRNA activation strategy is developed to achieve tumor‐specific siRNA therapy without gene inhibition in the normal tissues. The quaternary ammonium moieties are conjugated to amphiphilic copolymers via reactive oxygen species (ROS)‐sensitive thioketal (TK) linkers for co‐delivery of siRNA and photosensitizer chlorin e6 (Ce6), showing excellent siRNA complexation capacity and near infrared (NIR)‐controlled siRNA release. In the normal tissue, siRNAs are trapped and degraded in the endo‐lysosomes due to the unprotonatable property of quaternary ammonium moiety, showing the siRNA activity “off” state. When NIR irradiation is spatially applied to the tumor tissue, the NIR irradiation/Ce6‐induced ROS trigger siRNA endo‐lysosomal escape and cytosolic release through the photochemical internalization effect and cleavage of TK bonds, respectively, showing the siRNA activity “on” state. The siRNA‐mediated glutathione peroxidase 4 gene inhibition enhances ROS accumulation. The synergistic antitumor activity of Ce6 photodynamic therapy and gene inhibition is confirmed in vivo. Spatially controlled tumor‐specific siRNA activation and co‐delivery with Ce6 using unprotonatable and ROS‐sensitive cationic nanocarriers provide a feasible strategy for tumor‐specific siRNA therapy with synergistic drug effects.

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A polymer‑calcium phosphate nanocapsule for RNAi-induced oxidative stress and cascaded chemotherapy

Cited by 17 publications

References 59 publications

LAPONITE® nanodisk-based platforms for cancer diagnosis and therapy

LAPONITE® nanodisk-based platforms for cancer diagnosis and therapy

Calcium Phosphorus Nanoparticles Coloaded with Paclitaxel and ADAM‐10‐siRNA for the Treatment of Triple Negative Breast Cancer

Unprotonatable and ROS‐Sensitive Nanocarrier for NIR Spatially Activated siRNA Therapy with Synergistic Drug Effect

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