A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects

Fredriksson, Jenny; Carlsson, Enar; Orho‐Melander, Marju; Groop, Leif; Ridderstråle, Martin

doi:10.1038/sj.ijo.0803138

Cited by 40 publications

(29 citation statements)

References 52 publications

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“…Opposing also to our findings, other studies have provided that the 276 T allele was found to be protective for IR and the G/G genotype of SNP276 is a putative risk genotype which associated with lower plasma adiponectin levels and higher IR [30,31]. These conflicting association results in various populations suggesting a complex relationship between adiponectin gene variation and IR.…”

Section: Discussionsupporting

confidence: 59%

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

Abd-Elbaky¹,

Matty²

2016

J Diabetes Metab

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Type 2 diabetes mellitus (T2DM) is a metabolic pro-inflammatory disorder characterized by chronic hyperglycemia and increased levels of circulating cytokines. Adiponectin, tumor necrosis factor-α (TNF-α), interleukin-6 (Il-6), are important cytokines mediators in the pathogenesis of T2DM. The single nucleotide polymorphisms (SNPs) present in the regulatory regions of cytokine genes often have an impact on their expression levels.Aim: Explore potential associations between SNP+276 G/T of adiponectin, SNP -308 G/A of TNF-α and SNP -174 C/G of IL-6 genes with T2DM and to assess its influence on their serum levels. Subjects and Methods:From the Egyptian population, we enrolled 95 T2DM patients and 85 non-diabetic controls. Serum adiponectin, TNF-α and IL-6 were measured. Genotyping for three SNPs of the adiponectin, TNF-α and IL-6 genes was performed by polymerase chain reaction-restriction fragment length polymorphism.Results: Subjects with the GT/TT genotype of SNP 276 were at increased risk for T2DM (OR=15.88, CI=7.56-33.31, P ≤ 0.01) and associated with hypoadiponectinemia compared with the GG genotype. Furthermore, the allelic frequency of the A allele of SNP 308 was significantly different between T2DM patients compared to controls (X 2 =30.54, P ≤ 0.0001). Moreover, Individuals with T2DM carrying the GA/AA genotypes had significantly higher serum TNF-α levels than those carrying GG genotype. In addition, Carriers of G allele of IL-6 were significantly more likely associated with T2DM.

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Section: Discussionsupporting

confidence: 59%

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

Abd-Elbaky¹,

Matty²

2016

J Diabetes Metab

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“…This tendency was statistically significant in men showing that TT subjects had higher 3-year body weight gain. It was found that T-allele of the +276G/T polymorphism was associated with higher body fat in Swedish population [39] and with severe obesity in a French Caucasian population [40].…”

Section: Discussionmentioning

confidence: 99%

A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change

et al. 2009

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“…50 One of the latter, the T276G genotype, is characterized by markedly lower visceral adipose expression of adiponectin. 51 A second single nucleotide polymorphism, T45G, has been investigated in relation to PCOS, and studies have shown a statistically definable Adipokines in reproduction DB Campos et al correlation between the occurrence of this gene form and the ovarian disorder. 52,53 Recent findings indicate that adiponectin may also be active in the uterus and placenta.…”

Section: Effects Of Adiponectin On Reproduction and Fertilitymentioning

confidence: 99%

The ‘beneficial’ adipokines in reproduction and fertility

et al. 2007

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The objective of this study was to review the available information on the signaling proteins produced by adipose tissue in the context of their role in regulating reproductive processes, including ovarian and uterine function. It is well known that both obesity and excessive leanness are associated with reproductive dysfunction. Adipokines are cytokines predominately or exclusively expressed by adipose tissue that circulate and affect target tissues. Four known adipokines, adiponectin, visfatin/ PBEF, omentin and vaspin, all increase tissue sensitivity to insulin, and are thus described as 'beneficial'. There is strong support for a role for adiponectin in the function of the ovary and placenta. There is evidence for direct effects of this adipokine on the late stages of folliculogenesis, and additive interactions of adiponectin with insulin and gonadotropins in inducing periovulatory changes in ovarian follicles. In addition, clinical and genomic studies associate hypoadiponectinemia with obesity-related reproductive disorders, including the polycystic ovarian syndrome. The roles for visfatin/PBEF, omentin and vaspin in reproduction remain to be established. The conclusion thus drawn is that the expression of insulin-sensitizing adipokines varies with adipose abundance. These adipokines have demonstrated both the potential effects on ovarian function and the possible effects on the formation of the placenta, acting through multiple mechanisms.

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A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects

Cited by 40 publications

References 52 publications

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

Adiponectin (+276 G/T), Tumor Necrosis Factor-alpha (-308 G/A) and Interleukin-6 (-174 C/G) Genes Polymorphisms in Egyptian Type 2 Diabetic Patients

A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change

The ‘beneficial’ adipokines in reproduction and fertility

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