A polypyrrole-based microchip for controlled drug release

Ge, Dongtao; Tian, Xiangdong; Qi, Rucai; Huang, Sanqing; Mu, Jing; Hong, Shimin; Ye, Shefang; Zhang, Xiuming; Li, Donghui; Shi, Wei

doi:10.1016/j.electacta.2009.08.049

Cited by 58 publications

(33 citation statements)

References 25 publications

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“…Their depicted device contain the silicon layer containing the drug well(s) and the upper set of electrodes, while the polydimethylsiloxane (PDMS; Staples, 2010) layer served to seal the well and hold the lower electrode (Chung et al, 2008). In a recent mechanistic study, it was suggested that polypyrrol (PPy) is suitable and attractive candidates for accommodating drugs for polypyrrole-based controlled release microchip due to unique redox properties (Ge et al, 2009;Staples, 2010). This microchip has been developed by electrochemical deposition of drugdoped polypyrrole films on the gold microelectrode arrays (Ge et al, 2009).…”

Section: Current Researches On Implantable Microchips For Drug Deliverymentioning

confidence: 99%

“…In a recent mechanistic study, it was suggested that polypyrrol (PPy) is suitable and attractive candidates for accommodating drugs for polypyrrole-based controlled release microchip due to unique redox properties (Ge et al, 2009;Staples, 2010). This microchip has been developed by electrochemical deposition of drugdoped polypyrrole films on the gold microelectrode arrays (Ge et al, 2009). Compared to the other reservoir-based microchip, the preparation procedure of this PPy-based microchip is simple and convenient (Ge et al, 2009).…”

Section: Current Researches On Implantable Microchips For Drug Deliverymentioning

confidence: 99%

“…The device is microfabricated by means of a sequential technique using silicon wafer (Lang, 1996;Santini et al, 1999) and microelectronic processing techniques including ultraviolet photolithography (Santini et al, 1998;Hilt & Peppas, 2005), chemical vapor deposition (Daniel et al, 2009), electron beam evaporation (Santini et al, 1998) and reactive ion etching (Santini et al, 2000b;Hilt & Peppas, 2005), bonding (Santini et al, 2011) using highly biocompatible materials (Ge et al, 2009). Each device contained reservoirs that extended completely through the wafer.…”

Section: Fabrication Of Microchip Reservoirs and Reservoir Capsmentioning

confidence: 99%

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Implantable microchip: the futuristic controlled drug delivery system

2014

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There is no doubt that controlled and pulsatile drug delivery system is an important challenge in medicine over the conventional drug delivery system in case of therapeutic efficacy. However, the conventional drug delivery systems often offer a limited by their inability to drug delivery which consists of systemic toxicity, narrow therapeutic window, complex dosing schedule for long term treatment etc. Therefore, there has been a search for the drug delivery system that exhibit broad enhancing activity for more drugs with less complication. More recently, some elegant study has noted that, a new type of micro-electrochemical system or MEMS-based drug delivery systems called microchip has been improved to overcome the problems related to conventional drug delivery. Moreover, micro-fabrication technology has enabled to develop the implantable controlled released microchip devices with improved drug administration and patient compliance. In this article, we have presented an overview of the investigations on the feasibility and application of microchip as an advanced drug delivery system. Commercial manufacturing materials and methods, related other research works and current advancement of the microchips for controlled drug delivery have also been summarized.

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Section: Current Researches On Implantable Microchips For Drug Deliverymentioning

confidence: 99%

Section: Current Researches On Implantable Microchips For Drug Deliverymentioning

confidence: 99%

Section: Fabrication Of Microchip Reservoirs and Reservoir Capsmentioning

confidence: 99%

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Implantable microchip: the futuristic controlled drug delivery system

2014

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“…Recently, our group extended the application of PPy nanowire network to this field, obtaining an effective drug release system with high adenosine triphosphate (ATP) release efficiency [5]. 2 It is well known that CPs can be used as drug carriers due to their unique dopingdedoping and stimulus-responsive property [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], where drugs can be incorporated into CPs as dopants and then be released upon electrical stimulation. Therefore, the capacity of drug loading is dependent on the doping level (which is usually low) and the type of drugs is restricted to the charged and small molecules.…”

Section: Introductionmentioning

confidence: 99%

Enhanced drug loading capacity of polypyrrole nanowire network for controlled drug release

et al. 2013

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For a conducting polymer (CP) based drug release system, drug loading is often accomplished by a doping process, in which drug is incorporated into polymer as dopant. Therefore, the drug loading capacity is relatively low and the range of drugs can be loaded is limited. In the present work, a polypyrrole (PPy) nanowire network is prepared by an electrochemical method and it is found that the micro-and nanogaps among the individual nanowires of the PPy nanowire network can be used as reservoir to store drugs. Therefore, the drug loading capacity is dependent on the volume of these micro-and nano-vacancies, instead of the doping level. The range of loaded drugs also can be theoretically extended to any drugs, instead of only charged dopants. In fact, it is confirmed here that both hydrophilic and lipophilic drugs can be loaded into the micro-and nano-gaps due to the amphilicity of the PPy nanowire network. As a result, both drug loading capacity and the range of drugs can be loaded are significantly improved. After being covered with a protective PPy film, controlled drug release from the prepared system is achieved by electrical stimulation (cyclic voltammetry, CV) and the amount of drug released can be controlled by changing the scan rate of CV and the thickness of the protective PPy film.

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“…Among these are corrosion protection [1,2], electronic devices such as diodes [3], capacitors [4] or transistors [5], electrochromic displays [6], rechargeable batteries [7,8] and solid electrolytes [9], electrostatic materials [10], drug release systems [11,12], electromechanical actuators [13], sensors [14,15] or biosensors [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Electrosynthesis and characterization of polymer films on silicon substrates for applications in micromanipulation

et al. 2012

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Aniline and p-phenylenediamine were electrochemically oxidized in aqueous solutions by potentiodynamic deposition using Cyclic Voltammetry (CV) technique Resulting polymer films electrodeposited on Si substrates were identified by infrared spectroscopy as polyaniline and poly(p-phenylenediamine) films. Cyclic voltammograms demonstrated that poly(p-phenylenediamine) films are non conductive contrary to polyaniline films which are conductive and electropolymerized through an autocatalytic mechanism. The morphological features (thickness, roughness, morphology) of the electrodeposited polymer films were determined using Profilometry, Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). Adhesion force properties of polymer films were also studied by means of force-distance curves obtained by Atomic Force Microscopy. The influence of some experimental parameters (potential scan speed, number of potential scans) was also studied. Thus, it was shown that the potential scan speed strongly influence both morphological features and force adhesion, when the influence of the number of potential scans was less important. Under optimal conditions, it was possible to obtain very adhesive polymer films that could be useful for the micromanipulation of Si objects.2

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A polypyrrole-based microchip for controlled drug release

Cited by 58 publications

References 25 publications

Implantable microchip: the futuristic controlled drug delivery system

Implantable microchip: the futuristic controlled drug delivery system

Enhanced drug loading capacity of polypyrrole nanowire network for controlled drug release

Electrosynthesis and characterization of polymer films on silicon substrates for applications in micromanipulation

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