A Population-Based Morphologically Structured Model for Hyphal Growth and Product Formation in Streptomycin Fermentation

Liu, Gang; Xing, Miao; Han, Qingguo

doi:10.1007/s11274-005-3648-z

Cited by 8 publications

(10 citation statements)

References 13 publications

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“…This model exhibits realistic hyphal shapes and indicates a self-similar tip growth mechanism consistent with that observed experimentally [42]. A population-based morphologically structured model for hyphal growth and product formation in streptomycin fermentation was successfully applied to batch fermentation process [43].…”

Section: Modeling In Fungal Morphologysupporting

confidence: 74%

Application of Actinobacterial and Fungal Morphology on the Design of Operating Strategies in Bioprocess Development

Panda

Rameshaiah²

2009

TOBIOTJ

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Various options in biotechnology have been exercised to produce industrially important metabolites from filamentous organisms. To select a suitable production strategy, the direct and indirect roles of morphological parameters in controlling bioprocess variables are observed. Some progress has been made in quantitation of morphology.Useful correlations have been reported in the literature in this avenue. Of course, some of the models, with proper modification, can be used to explain the morphological phenomena. This review is concerned with the application of morphological variables to correlate with bioprocess parameters for explaining optimal production strategy.

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Section: Modeling In Fungal Morphologysupporting

confidence: 74%

Application of Actinobacterial and Fungal Morphology on the Design of Operating Strategies in Bioprocess Development

Panda

Rameshaiah²

2009

TOBIOTJ

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“…In silico models have been developed to better understand mycelial growth (389)(390)(391), although many were primarily based on physiological and nutritional parameters. Helped by the strong increase in computing power in the modern era, new models were developed recently (392,393).…”

Section: Correlation Between Growth and Antibiotic Productionmentioning

confidence: 99%

Taxonomy, Physiology, and Natural Products of Actinobacteria

Barka

Vatsa

Sanchez

et al. 2016

Microbiol Mol Biol Rev

1,600

1,048

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SUMMARYActinobacteriaare Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and terrestrial ecosystems. ManyActinobacteriahave a mycelial lifestyle and undergo complex morphological differentiation. They also have an extensive secondary metabolism and produce about two-thirds of all naturally derived antibiotics in current clinical use, as well as many anticancer, anthelmintic, and antifungal compounds. Consequently, these bacteria are of major importance for biotechnology, medicine, and agriculture.Actinobacteriaplay diverse roles in their associations with various higher organisms, since their members have adopted different lifestyles, and the phylum includes pathogens (notably, species ofCorynebacterium,Mycobacterium,Nocardia,Propionibacterium, andTropheryma), soil inhabitants (e.g.,MicromonosporaandStreptomycesspecies), plant commensals (e.g.,Frankiaspp.), and gastrointestinal commensals (Bifidobacteriumspp.).Actinobacteriaalso play an important role as symbionts and as pathogens in plant-associated microbial communities. This review presents an update on the biology of this important bacterial phylum.

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“…To predict the effect of culturing conditions as well as genetic factors on morphology, many different in silico models have been designed in the past (Liu, Xing, & Han, 2005;Meyerhoff, Tiller, & Bellgardt, 1995;Nielsen & Villadsen, 1992;Tough & Prosser, 1996;Yang, King, Reichl, & Gilles, 1992). The older models largely focused on the influence of environmental factors on morphology, while genetics-based modeling had not been attempted (Kossen, 2000).…”

Section: Outlook: the Correlation Between Morphology And Productionmentioning

confidence: 99%

Morphogenesis of Streptomyces in Submerged Cultures

Dissel

Claessen

Wezel

2014

Advances in Applied Microbiology

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Members of the genus Streptomyces are mycelial bacteria that undergo a complex multicellular life cycle and propagate via sporulation. Streptomycetes are important industrial microorganisms, as they produce a plethora of medically relevant natural products, including the majority of clinically important antibiotics, as well as a wide range of enzymes with industrial application. While development of Streptomyces in surface-grown cultures is well studied, relatively little is known of the parameters that determine morphogenesis in submerged cultures. Here, growth is characterized by the formation of mycelial networks and pellets. From the perspective of industrial fermentations, such mycelial growth is unattractive, as it is associated with slow growth, heterogeneous cultures, and high viscosity. Here, we review the current insights into the genetic and environmental factors that determine mycelial growth and morphology in liquid-grown cultures. The genetic factors include cell-matrix proteins and extracellular polymers, morphoproteins with specific roles in liquid-culture morphogenesis, with the SsgA-like proteins as well-studied examples, and programmed cell death. Environmental factors refer in particular to those dictated by process engineering, such as growth media and reactor set-up. These insights are then integrated to provide perspectives as to how this knowledge can be applied to improve streptomycetes for industrial applications.

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A Population-Based Morphologically Structured Model for Hyphal Growth and Product Formation in Streptomycin Fermentation

Cited by 8 publications

References 13 publications

Application of Actinobacterial and Fungal Morphology on the Design of Operating Strategies in Bioprocess Development

Application of Actinobacterial and Fungal Morphology on the Design of Operating Strategies in Bioprocess Development

Taxonomy, Physiology, and Natural Products of Actinobacteria

Morphogenesis of Streptomyces in Submerged Cultures

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