A population‐based study of animal component sensitization, asthma, and rhinitis in schoolchildren

Bjerg, Anders; Winberg, Anna; Berthold, Malin; Mattsson, Lars; Borres, Magnus P.; Rönmark, Eva

doi:10.1111/pai.12422

Cited by 69 publications

(98 citation statements)

References 30 publications

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“…They stated the importance of identifying specific allergen components associated with asthma and severe disease. Bjerg et al reported a higher prevalence of asthma in children co-sensitized to rFel d1 and rFel d 4 than in children sensitized to r Fel d 1 alone [50]. We also saw a higher prevalence of reported asthma (55%) in patients with IgE reactivity, not only toward rFel d 1, but also toward nFel d 2 and/or rFel d 4.…”

Section: Discussionsupporting

confidence: 59%

Usefulness of component resolved analysis of cat allergy in routine clinical practice

Eder

Becker

Nicoló

et al. 2016

Allergy Asthma Clin Immunol

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BackgroundCat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization and allergy are known risk factors for rhinitis, bronchial hyperreactivity and asthma. Thus, the diagnosis of sensitization to cats is important for any allergist.Methods70 patients with positive skin prick tests for cats were retrospectively compared regarding their skin prick test results, as well as their specific immunoglobulin E antibody profiles with regard to their responses to the native cat extract, rFel d 1, nFel d 2 and rFel d 4. 35 patients were allergic to cats, as determined by positive anamnesis and/or nasal provocation with cat allergens, and 35 patients exhibited clinically non-relevant sensitization, as indicated by negative anamnesis and/or a negative nasal allergen challenge.ResultsNative cat extract serology testing detected 100% of patients who were allergic to cats but missed eight patients who showed sensitization in the skin prick test and did not have allergic symptoms. The median values of the skin prick test, as well as those of the specific immunoglobulin E antibodies against the native cat extract, were significantly higher for allergic patients than for patients with clinically non-relevant sensitization. Component based diagnostic testing to rFel d 1 was not as reliable. Sensitization to nFel d 2 and rFel d 4 was seen only in individual patients.ConclusionExtract based diagnostic methods for identifying cat allergy and sensitization, such as the skin prick test and native cat extract serology, remain crucial in routine clinical practice. In our study, component based diagnostic testing could not replace these methods with regard to the detection of sensitization to cats and differentiation between allergy and sensitization without clinical relevance. However, component resolved allergy diagnostic tools have individual implications, and future studies may facilitate a better understanding of its use and subsequently may improve the clinical management of allergic patients.

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Section: Discussionsupporting

confidence: 59%

Usefulness of component resolved analysis of cat allergy in routine clinical practice

Eder

Becker

Nicoló

et al. 2016

Allergy Asthma Clin Immunol

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“…A study by Bjerg et al [5] found sensitization to the Fel d 1 component in 83.7% of its research group, which comprised of 208 children aged 11–12 sensitized to felines. In that group monosensitization was found in 67.8% of patients [5]. …”

Section: Discussionmentioning

confidence: 99%

“…The levels of IgE were evaluated as heightened when they exceeded 0.35 kU/l, in accordance with common practice in the field [5, 6]. …”

Section: Methods and Research Materialsmentioning

confidence: 99%

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Analysis of feline and canine allergen components in patients sensitized to pets

Ukleja-Sokołowska

Gawrońska-Ukleja

Żbikowska-Gotz

et al. 2016

Allergy Asthma Clin Immunol

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BackgroundComponent resolved allergen diagnosis allows for a precise evaluation of the sensitization profiles of patients sensitized to felines and canines. An accurate interpretation of these results allows better insight into the evolution of a given patients sensitizations, and allows for a more precise evaluation of their prognoses.Methods70 patients (42 women and 28 men, aged 18–65, with the average of 35.5) with a positive feline or canine allergy diagnosis were included in the research group. 30 patients with a negative allergy diagnosis were included in the control group. The total IgE levels of all patients with allergies as well as their allergen-specific IgE to feline and canine allergens were measured. Specific IgE levels to canine (Can f 1, Can f 2, Can f 3, Can f 5) and feline (Fel d 1, Fel d 2, Fel d 4) allergen components were also measured with the use of the ImmunoCap method.ResultsMonosensitization for only one canine or feline component was found in 30% of patients. As predicted, the main feline allergen was Fel d 1, which sensitized as many as 93.9% of patients sensitized to felines. Among 65 patients sensitized to at least one feline component, for 30 patients (46.2%) the only sensitizing feline component was Fel d 1. Only 19 patients in that group (63.3%) were not simultaneously sensitized to dogs and 11 (36.7%), the isolated sensitization to feline Fel d 1 notwithstanding, displayed concurrent sensitizations to one of the canine allergen components. Fel d 4 sensitized 49.2% of the research group.64.3% of patients sensitized to canine components had heightened levels of specific IgE to Can f 1. Monosensitization in that group occurred for 32.1% of the patients. Sensitization to Can f 5 was observed among 52.4% of the patients.ConclusionsConcurrent sensitizations to a few allergic components, not only cross-reactive but also originating in different protein families, are a significant problem for patients sensitized to animals.

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“…Sensitization also differs by sociodemographic factors, including age, gender, race/ethnicity and socioeconomic status [51]. Novel data on sensitization patterns have emerged from recent studies that have used component-resolved diagnostics to increase knowledge on sensitization profiles and cross-reactivity [28, 49, 54, 55]. Numerous studies have demonstrated that sensitization, especially high pet-specific IgE levels and co-sensitization, are strongly associated with the prevalence, severity and persistence of asthma [5, 26, 49, 54, 56–58].…”

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

Bedroom Allergen Exposure Beyond House Dust Mites

Salo

Cohn²,

Zeldin

2018

Curr Allergy Asthma Rep

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Purpose of the review: The review provides insight into recent findings on bedroom allergen exposures, primarily focusing on pet, pest and fungal exposures. Recent findings: Large-scale studies and improved exposure assessment technologies, including measurement of airborne allergens and of multiple allergens simultaneously, has extended our understanding of indoor allergen exposures and their impact on allergic disease. Practical, streamlined methods for exposure reduction have shown promise in some settings, and potential protective effects of early-life exposures have been further elucidated through the investigation of specific bacterial taxa. Advances in molecular allergology have yielded novel data on sensitization profiles and cross-reactivity. Summary: The role of indoor allergen exposures in allergic disease is complex and remains incompletely understood. Advancing our knowledge of various co-exposures, including the environmental and host microbiome, that interact with allergens in early life will be crucial for the development of efficacious interventions to reduce the substantial economic and social burden of allergic diseases including asthma.

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A population‐based study of animal component sensitization, asthma, and rhinitis in schoolchildren

Abstract: Among schoolchildren in northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk.

Cited by 69 publications

References 30 publications

Usefulness of component resolved analysis of cat allergy in routine clinical practice

Usefulness of component resolved analysis of cat allergy in routine clinical practice

Analysis of feline and canine allergen components in patients sensitized to pets

Bedroom Allergen Exposure Beyond House Dust Mites

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