A population-based study of the stratum corneum moisture

Abstract

BackgroundThe stratum corneum (SC) has important functions as a bound-water modulator and a primary barrier of the human skin from the external environment. However, no large epidemiological study has quantified the relative importance of different exposures with regard to these functional properties. In this study, we have studied a large sample of individuals from the Brazilian population in order to understand the different relationships between the properties of SC and a number of demographic and self-perceived variables.MethodsOne thousand three hundred and thirty-nine individuals from a rural Brazilian population, who were participants of a family-based study, were submitted to a cross-sectional examination of the SC moisture by capacitance using the Corneometer® CM820 and investigated regarding environmental exposures, cosmetic use, and other physiological and epidemiological measurements. Self-perception-scaled questions about skin conditions were also applied.ResultsWe found significant associations between SC moisture and sex, age, high sun exposure, and sunscreen use frequency (P<0.025). In specific studied sites, self-reported race and obesity were also found to show significant effects. Dry skin self-perception was also found to be highly correlated with the objective measurement of the skin. Other environmental effects on SC moisture are also reported.

Identification of an optimal method for extracting RNA from human skin biopsy, using domestic pig as a model system

“…The difference may be due to the unequal water content in tissues before extracting the RNA. Variation in skin water content can be caused by different age, sex (menstrual cycle in case of women), and environmental factors (such as water consumption prior to sample collection) 22–25 . In the present study, pigs were all immature females from the same age group and grew up together in same environmental conditions.…”

Effect of seasonal change on the biomechanical and physical properties of the human skin

“…To avoid further animal tests in empirical investigations, non-invasive apparatus for cutaneous in vivo assessments has been developed [14] which this study used to measure the effects of this seasonal change on the biomechanical properties of the human skin. Properties studied include trans-epidermal water loss (TEWL), thickness and roughness of the skin as well as skin stiffness and recovery from axial deformations.…”

“…Properties studied include trans-epidermal water loss (TEWL), thickness and roughness of the skin as well as skin stiffness and recovery from axial deformations. In line with the hypothesis from [14] that environmental exposure can alter skin properties, biophysical properties like hydration and pigmentation were also investigated with their statistical correlations considered.…”

A Face Serum Containing Bakuchiol, Palmitoyl Tripeptide-38, Hydrolyzed Hyaluronic Acid and a Polyherbal and Vitamin Blend Improves Skin Quality in Human Volunteers and Protects Skin Structure In vitro

“…Skin hydration was measured with a Corneometer® CM 825 probe (Courage+Khazaka). This is one of the most well-documented non-invasive methods for reproducibly and accurately measuring the moisture level of the stratum corneum [25]. This method is based on capacitance measurements of the skin, in which the dielectric constant will change with water content.…”