A population‐based survey of frequencies of self‐reported spontaneous and induced abortions in Danish women with Type 1 diabetes mellitus

Lorenzen, Tove; Pociot, Flemming; Johannesen, Jesper; Kristiansen, Ole Peter; Nerup, Jørn

doi:10.1046/j.1464-5491.1999.00087.x

Cited by 25 publications

(14 citation statements)

References 22 publications

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“…An abortion rate of approximately 40 % has been found in a previous population-based survey of self-reported abortions in Danish women with Type I diabetes [27]. The generally high abortion rate found in our study could be a chance finding or perhaps be due to poor metabolic control [28] or the existence of microangiopathy [29].…”

Section: Discussionsupporting

confidence: 61%

Pregnancy and progression of diabetic nephropathy

et al. 2002

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Section: Discussionsupporting

confidence: 61%

Pregnancy and progression of diabetic nephropathy

et al. 2002

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“…Studies have also reported increased rates of spontaneous abortion among women with type 1 diabetes [5], and of perinatal mortality and birth defects among women with either type 1 or type 2 diabetes [6, 7]. …”

Section: Introductionmentioning

confidence: 99%

Fecundability among women with type 1 and type 2 diabetes in the Norwegian Mother and Child Cohort Study

et al. 2010

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Aims/Hypothesis We assessed the effects of type 1 diabetes and type 2 diabetes on fecundability (as manifest by increased time-to-pregnancy (TTP)) in a large cohort of pregnant women. Methods This study is based on the Norwegian Mother and Child Cohort Study (MoBa). Members of this large cohort were enrolled early in pregnancy and asked about TTP and other factors. Among the 58,004 women included in the analysis, we identified 221 cases of type 1 diabetes and 88 cases of type 2 diabetes using the Medical Birth Registry of Norway. A logistic analog of the proportional probability model, a Cox-like discrete-time model, was used to compute fecundability odds ratios (FOR) and 95% CI for type 1 diabetes and type 2 diabetes, adjusted for maternal age and prepregnancy BMI. Results Compared with non-diabetic women, the adjusted FOR for women with type 1 diabetes was 0.76 (95% CI=0.64, 0.89) and the adjusted FOR for women with type 2 diabetes was 0.64 (95% CI=0.48, 0.84). These FORs did not change substantively and remained statistically significant after excluding women with irregular menstrual cycles and accounting for cycle length. Conclusions/Interpretation The results from the present study provide evidence of substantially decreased fecundability for women with type 1 and type 2 diabetes, even among those with normal menstrual cycles.

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“…In a Danish questionnaire study, 17.9% of reported pregnancies in women with type 1 diabetes ended with termination [13]. This study included women aged 20-65 years, which means that many of them were still of reproductive age.…”

Section: Discussionmentioning

confidence: 99%

“…The studies on termination in women with type 1 diabetes all report the proportion of terminations among all pregnancies, which varies from 7% to 18% [11][12][13][14][15]. Of these, the proportion performed for medical reasons varies between 25% and 37%.…”

Section: Introductionmentioning

confidence: 99%

Termination of pregnancy and sterilisation in women with childhood-onset type 1 diabetes

et al. 2017

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Aims/hypothesis The aim of this study was to explore the association between type 1 diabetes and reproductive health indicators in women, focusing on termination of pregnancy and sterilisation. Methods We conducted a registry-based cohort study involving 2281 women with childhood-onset type 1 diabetes, matched for age and birthplace with women without diabetes: two control participants for each woman with diabetes. We compared the frequencies of termination of pregnancy and sterilisation over a 25 year period between women with type 1 diabetes and women without, and estimated standardised incidence ratios (SIRs). Smoothed age and period effects in the incidence of termination of pregnancy or sterilisation were tested statistically.Results There were more terminations of pregnancy (SIR 1.67; 95% CI 1.51, 1.86) and sterilisations (SIR 1.69; 95% CI 1.56, 1.83) in women with diabetes than in control women. During recent years, sterilisations in women with diabetes have decreased and the difference compared with control women has vanished. The indications for both procedures showed a statistically highly significant difference: maternal medical indications were almost absent (< 1%) in procedures among control women, but comprised 23.6% of terminations of pregnancy and 22.9% of sterilisations in women with diabetes. Conclusions/interpretation The indications for termination of pregnancy and sterilisation are different in women with diabetes compared with other women. Pregnancies in women with type 1 diabetes are still terminated more often than in Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00125-017-4428-7) contains peer-reviewed but unedited supplementary material, which is available to authorised users. * Lena Sjöberg

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A population‐based survey of frequencies of self‐reported spontaneous and induced abortions in Danish women with Type 1 diabetes mellitus

Cited by 25 publications

References 22 publications

Pregnancy and progression of diabetic nephropathy

Pregnancy and progression of diabetic nephropathy

Fecundability among women with type 1 and type 2 diabetes in the Norwegian Mother and Child Cohort Study

Termination of pregnancy and sterilisation in women with childhood-onset type 1 diabetes

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