A Population Study of Alzheimer's Disease: Findings From the Cache County Study on Memory, Health, and Aging

Tschanz, JoAnn T.; Treiber, Katherine; Norton, Maria C.; Welsh‐Bohmer, Kathleen A.; Toone, Leslie; Zandi, Peter P.; Szekely, Christine A.; Breitner, John C.S.

doi:10.1891/152109805780650733

Cited by 5 publications

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“…The study uses a longitudinal design to follow-up with caregivers and care recipients after the care recipient is identified as having dementia through the Cache County Study on Memory in Aging (CCSMA; Tschanz et al, 2005). A brief description of the procedures to identify persons with dementia in the parent study, CCSMA, follows.…”

Section: Methodsmentioning

confidence: 99%

Dementia caregivers’ coping strategies and their relationship to health and well-being: the Cache County Study

Snyder

Fauth

Wanzek

et al. 2014

Aging & Mental Health

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Objectives Prior research identifies that psychological outcomes among dementia caregivers are associated with their use of coping strategies. Few studies have tested the association of coping and health longitudinally. Method This study examined factors associated with the use of coping strategies over time and their associations with physical and mental health outcomes in a population-based sample of 226 dementia caregivers in Cache County, Utah. Caregivers annually completed the Ways of Coping Checklist-Revised, the Beck Anxiety Inventory, and a health interview. Care-recipient cognitive and functional abilities were obtained using the Mini-Mental State Exam and the Clinical Dementia Rating. Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory. Results Caregivers most frequently identified providing care as a problem (37.6%). Linear mixed models of caregiver coping strategies found that the use of most strategies were stable except for increasing Avoidance among adult child caregivers (β = 0.14, p = 0.048). On average, increased Wishful Thinking (β = 2.48, p < 0.001) or Blames Self (β = 1.06, p = 0.002) was associated with higher anxiety scores. Increased use of Blames Others among males (interaction, β = 0.28, p = 0.02) and greater use of Wishful Thinking among younger caregivers (interaction, β = −0.01, p = 0.01) was associated with more health conditions in the caregiver. Coping strategies were not associated with caregivers’ change in anxiety or number of health conditions over time. Conclusion Our results emphasize the importance of caregiver coping strategies on caregiver health and well-being and may identify subgroups of persons at risk for worse outcomes.

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Section: Methodsmentioning

confidence: 99%

Dementia caregivers’ coping strategies and their relationship to health and well-being: the Cache County Study

Snyder

Fauth

Wanzek

et al. 2014

Aging & Mental Health

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“…These cases are now presumed to reflect tauopathies, which are a diverse group of diseases that may be associated with genetic (tau mutations) or environmental (Guamian or postencephalitic parkinsonism) factors (3, 5). In most population-based series, and in older patients, tauopathies are uncommon (54, 57, 67). …”

Section: Clinicopathologic Correlation In the Context Of Ad: The Goalmentioning

confidence: 99%

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

Nelson

Braak

Markesbery

2009

J Neuropathol Exp Neurol

535

397

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Amyloid plaques and neurofibrillary tangles (NFTs) are the pathological hallmarks of Alzheimer disease (AD). There is controversy regarding the use of current diagnostic criteria for AD and whether amyloid plaques and NFTs contribute to cognitive impairment. Because AD is specific to humans, rigorous and comprehensive clinicopathologic studies are necessary to test and refine hypotheses of AD diagnosis and pathogenesis. Neither the clinical nor the pathological aspects of AD evolve in a linear manner, but the predictable sequence of AD pathology allows for stage-based correlations with cognitive deterioration. We discuss subsets of patients with clinical dementia who lack amyloid plaques and NFTs and, conversely, whether individuals without antemortem cognitive impairment can harbor severe AD-type pathological findings at autopsy. There are many medical, technical, and anatomical challenges to clinicopathologic studies in AD. For example, at least two thirds of persons older than 80 years have non-AD brain diseases that can effect on cognitive function. We argue that existing data strongly support the hypothesis that both amyloid plaques and NFTs contribute to cognitive impairment.

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“…79 It is important to remain aware of the fact that not all carriers of the ε4 allele develop AD, even if they live to advanced old age, and many without ε4 do manifest the disease. 57,61,62,[80][81][82][83] A variety of interacting risk and protective factors (as discussed below) has been implicated, but the mechanisms of these interactions are as yet to be explored. Meanwhile, the value of APOE in the diagnosis of AD remains to be established.…”

Section: Genetic Risk Factorsmentioning

confidence: 99%

Children of Persons With Alzheimer Disease

Jarvik¹,

LaRue²,

Blacker³

et al. 2008

Alzheimer Disease &Amp; Associated Disorders

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A Population Study of Alzheimer's Disease: Findings From the Cache County Study on Memory, Health, and Aging

Cited by 5 publications

References 0 publications

Dementia caregivers’ coping strategies and their relationship to health and well-being: the Cache County Study

Dementia caregivers’ coping strategies and their relationship to health and well-being: the Cache County Study

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

Children of Persons With Alzheimer Disease

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