A portable automatic pressure delivery system for scar compression therapy in large animals

Ghassemi, Pejhman; Shupp, Jeffrey W.; Travis, Taryn E; Gravunder, Andrew J.; Moffatt, Lauren T.; Ramella‐Roman, Jessica C.

doi:10.1063/1.4904842

Cited by 13 publications

(11 citation statements)

References 21 publications

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“…The use of the APDS device in this model has been previously described [29], but its use remains novel and limited. The results of this study add more validity to this combined hypertrophic scar and APDS model in studying the effect of pressure on hypertrophic scars.…”

Section: Discussionmentioning

confidence: 99%

“…By day 70 post-wound creation, all wounds were confirmed to have formed hypertrophic scars. At this point, an automatic pressure delivery system (APDS) for scar compression therapy [29] was mounted onto hypertrophic scars for treatment as previously described [28]. This device consisted of a polycarbonate enclosure that housed a wireless communication device (XBee 2.4 GHz RF modem, Digi International, Inc., Minnetonka, MN) and a compression plate for pressure delivery onto hypertrophic scar.…”

Section: Methodsmentioning

confidence: 99%

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Compression therapy affects collagen type balance in hypertrophic scar

Tejiram

Zhang

Travis

et al. 2016

Journal of Surgical Research

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Background The effects of pressure on hypertrophic scar are poorly understood. Decreased extracellular matrix deposition is hypothesized to contribute to changes observed after pressure therapy. To examine this further, collagen composition was analyzed in a model of pressure therapy in hypertrophic scar. Materials and Methods Hypertrophic scars created on red Duroc swine (n=8) received pressure treatment (pressure device mounting and delivery at 30 mm Hg), sham treatment (device mounting and no delivery), or no treatment for two weeks. Scars were assessed weekly and biopsied for histology, hydroxyproline quantification, and gene expression analysis. Transcription levels of collagen precursors COL1A2 and COL3A1 were quantified using RT-PCR. Masson’s trichrome was used for general collagen quantification while immunofluorescence was used for collagen types I and III specific quantification. Results Total collagen quantification using hydroxyproline assay showed a 51.9% decrease after pressure initiation. Masson’s trichrome staining showed less collagen after one (p<0.03) and two (p<0.002) weeks of pressure application compared to sham and untreated scars. Collagen 1A2 and 3A1 transcript decreased by 41.9 and 42.3 fold, respectively, compared to uninjured skin after pressure treatment while a 2.3 and 1.3 fold increase was seen in untreated scars. This decrease was seen in immunofluorescence staining for collagen types I (p<0.001) and III (p<0.04) compared to pretreated levels. Pressure treated scars also had lower levels of collagen I and III after pressure treatment (p<0.05) compared to sham and untreated scars. Conclusion These results demonstrate the modulation of collagen following pressure therapy and further characterize its role in scar formation and therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Compression therapy affects collagen type balance in hypertrophic scar

Tejiram

Zhang

Travis

et al. 2016

Journal of Surgical Research

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“…In addition, this extreme condition is seemingly necessary to induce highly active, tumour like cells undergoing apoptosis. To date, although many hypertrophic scar treatment modalities have been developed with varying degree of success, compression therapy has long been a standard treatment for hypertrophic scar prevention, perhaps the key mechanism underlying this treatment is also related to severe hypoxia and malnutrition caused by the tropic pressure.…”

Section: Discussionmentioning

confidence: 99%

Severe hypoxia and malnutrition collectively contribute to scar fibroblast inhibition and cell apoptosis

Lynam

Xie

Dawson

et al. 2015

Wound Repair Regeneration

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This study aims to investigate whether severe hypoxia and malnutrition in scar tissue play key roles to induce hypertrophic scar regression. And scar‐derived fibroblasts were treated with moderate/severe hypoxia and malnutrition to model condition of proliferative and regressive scar (5%O2+5%FCS and 0.5%O2 + 0.5%FCS), and normoxia with well nutrition as control (10%O2 + 10%FCS). Our results demonstrated that severe hypoxia and malnutrition resulted in significantly reduced cell viability and collagen production, as well as HIF‐1, VEGF, TGF‐β1, and Bcl‐2 protein expression when compared with control, and cell apoptosis occurred. Therefore, the severe hypoxia and malnutrition in scar tissue contribute to fibroblast inhibition and cell apoptosis, which is correlated with scar regression.

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“…The ex vivo studies expressed the capability of this medical device on promoting the quality of hypertrophic scars by constantly delivering 30 mmHg pressure on the wound scars for 2 weeks. [ 160 ]…”

Section: Evolutionary Trend Of Wound Dressingsmentioning

confidence: 99%

“…[ 158,159 ] Recently, combining 3D‐printed biomimetic wound dressings and stem cell therapy has emerged as a promising strategy for promoting wound healing with reduced scar tissue formation. [ 160 ]…”

Section: Bioinspired Active Dressingsmentioning

confidence: 99%

Wound Healing: From Passive to Smart Dressings

Farahani

Shafiee

2021

Adv Healthcare Materials

417

219

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The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden on the patients and healthcare systems. Although, the application of traditional wound dressings contributes to an effective wound healing outcome, yet, the complexity of the healing process remains a major health challenge. Recent advances in materials and fabrication technologies have led to the fabrication of dressings that provide proper conditions for effective wound healing. The 3D‐printed wound dressings, biomolecule‐loaded dressings, as well as smart and flexible bandages are among the recent alternatives that have been developed to accelerate wound healing. Additionally, the new generation of wound dressings contains a variety of microelectronic sensors for real‐time monitoring of the wound environment and is able to apply required actions to support the healing progress. Moreover, advances in manufacturing flexible microelectronic sensors enable the development of the next generation of wound dressing substrates, known as electronic skin, for real‐time monitoring of the whole physiochemical markers in the wound environment in a single platform. The current study reviews the importance of smart wound dressings as an emerging strategy for wound care management and highlights different types of smart dressings for promoting the wound healing process.

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A portable automatic pressure delivery system for scar compression therapy in large animals

Cited by 13 publications

References 21 publications

Compression therapy affects collagen type balance in hypertrophic scar

Compression therapy affects collagen type balance in hypertrophic scar

Severe hypoxia and malnutrition collectively contribute to scar fibroblast inhibition and cell apoptosis

Wound Healing: From Passive to Smart Dressings

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