2015
DOI: 10.1016/j.bios.2014.09.061
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A portable low-cost long-term live-cell imaging platform for biomedical research and education

Abstract: Time-resolved visualization and analysis of slow dynamic processes in living cells has revolutionized many aspects of in vitro cellular studies. However, existing technology applied to time-resolved live-cell microscopy is often immobile, costly and requires a high level of skill to use and maintain. These factors limit its utility to field research and educational purposes. The recent availability of rapid prototyping technology makes it possible to quickly and easily engineer purpose-built alternatives to co… Show more

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Cited by 71 publications
(60 citation statements)
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“…There are some smartphone based devices that are not found in the app stores, but there is a clear displacement of lab equipment using mobile technology, such as in the areas of microplate reading (Berg et al, 2015;Christodouleas et al 2015;Fu et al, 2016), live cell imaging (Walzik et al, 2015), microfluidics for cancer detection (Barbosa et al, 2015), food allergen detection (Coskun et al, 2013), and immunochromatgraphic detection of bacteria (Rajendran et al, 2014).Nonetheless, there are areas where no changes are expected; and this is the work of dangerous chemical and pathogens (e.g. Biohazard Class 3 work).…”
Section: Resultsmentioning
confidence: 99%
“…There are some smartphone based devices that are not found in the app stores, but there is a clear displacement of lab equipment using mobile technology, such as in the areas of microplate reading (Berg et al, 2015;Christodouleas et al 2015;Fu et al, 2016), live cell imaging (Walzik et al, 2015), microfluidics for cancer detection (Barbosa et al, 2015), food allergen detection (Coskun et al, 2013), and immunochromatgraphic detection of bacteria (Rajendran et al, 2014).Nonetheless, there are areas where no changes are expected; and this is the work of dangerous chemical and pathogens (e.g. Biohazard Class 3 work).…”
Section: Resultsmentioning
confidence: 99%
“…Alongside different imaging modalities, long-term observations of living organisms with the least possible bias on their behaviour became an important aspect in microscopy. Keeping the cells in a well-controlled environment and state pose additional constraints like imaging inside an incubator [4,5] with appropriate microscopes [6,7,8] or on-microscope incubator units [9]. Assembling, maintaining and improving such setups as well as analysing and verifying the produced data very often requires a specialist dedicated to the respective instrument, separating microscope engineers from microscope users.…”
Section: Introduction Generalmentioning
confidence: 99%
“…It is a great choice to combine image analysis with smartphone-based application. For biomedical research, the image analysis is utilized in the construction of low-cost cell-based biosensor [13,14]. On the other hand, many biochemical analysis platforms or methods combined with smartphone appear one after another in point-of-care test domain due to the high integration of smartphone to processor and diverse sensors [15,16].…”
Section: Introductionmentioning
confidence: 99%