A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna

Abstract

Mesna is an important regional antidote for protecting the urinary system of chemotherapy patients, which requires monitoring its level in real time to ensure the curative effect. The fluorescence method is a powerful tool in real-time detection with the advantages of fast response and visualization. However, the background interference limits its application in biological sensing. Here, we developed a portable sensing platform using an upconversion-based nanosensor for visual quantitative monitoring of mesna in real-time/on-site conditions. The nanosensor was constructed by upconversion nanoparticles (UCNPs) and ethyl violet (EV), in which the UCNPs emitted red and green light, while EV quenched the green light due to the inner filter effect (IFE). The reaction of mesna with EV caused its fading and broke the IFE process, leading to the recovery of green light. By the fluorescence and colorimetric chromaticity variations, the nanosensor achieved a dual-readout detection for mesna with low limits of detection (LODs) of 26 and 48 nM, respectively. Furthermore, a highly compatible sensing platform was fabricated for facile determination of mesna with an LOD of 56 nM, realizing visual quantitative monitoring of the mesna level to ensure the curative effect and providing a new strategy for point-of-care testing of drugs in clinical settings.

Polyethyleneimine-Sulfur Quantum Dot Composites for Dual-Channel Detection of Tetracycline by Colorimetric and Fluorescence Sensing

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“…A dual detection for Fe 2+ and H 2 O 2 with SQDs has been reported, but the defect is the high detection limit and inability to achieve accurate quantitative detection by naked-eye identification . Other creative sensing systems were constructed by integrating a smartphone and 3D printing for the detection of Mesna and Cr 6+ . , TC has a β-diketone group in the molecular structure, which can coordinate with Eu 3+ through O and N atoms. The coordinated ligands have perturbation on d -orbitals and break down the symmetry of some electronic states derived from the d -orbitals, which then results in the relaxation of the LaPorte selection rule and causes the intensification of d–d transition of Eu 3+ .…”

A smartphone-based device for simultaneous measurement of ratiometric fluorescence and absorbance demonstrated by the determination of hypochlorous acid

“…It should be noted that eqn (10) is an approximation because only the first term of the Taylor series in eqn ( 8) is used. Anyway, eqn (10) is also helpful to explain the near-linear correlations between the light intensity or hue of the colorimetric images and concentration of target analytes in visible regions, [37][38][39][40][41][42][43][44][45] which are also due to the non-linear response of the CCD in the camera to light intensity (eqn (3)). But the value of G 3 is dependent on the values of G 1 and G 30 .…”

A Wearable Electrochemical Biosensor for Lactate Monitoring in Sweat

“…[14]- [23] However, current electrical wearable detection of lactate can be limited by its low sensitivity, poor stability, requirement of external power sources, sophisticated fabrications, and high cost. [24]- [31] Hence, it is imperative to develop new strategies to fabricate cost-effective wearables. in this work, we presented a new inkjet printable reduced graphene oxide (rGO) ink method to fabricate a low-cost chemiresistive biosensor for lactate detection from sweat matrix with high sensitivity and selectivity, via inkjet printing of the rGO ink followed by optimized functionalizations.…”