A positron emission tomography study of short- and long-term treatment effects on functional brain activation in adults who stutter

Nil, Luc F. De; Kroll, Robert M.; Lafaille, Sophie J.; Houle, Sylvain

doi:10.1016/j.jfludis.2003.07.002

Cited by 124 publications

(83 citation statements)

References 22 publications

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“…According to this view, the right hemisphere inferior frontal activation is a secondary consequence of the root problem, which is aberrant performance in the feedforward system. Poor feedforward performance leads to auditory errors that in turn activate the right-lateralized auditory feedback control system in an attempt to correct for the errors This hypothesis is consistent with the affects of fluency-inducing therapy on BOLD responses; successful treatment has been associated with a shift toward more normal, left-lateralized frontal activation (De Nil et al, 2003;Neumann et al, 2005).…”

Section: Implications For Speech Disorderssupporting

confidence: 67%

Neural mechanisms underlying auditory feedback control of speech

2008

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The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling. Neural responses were measured while subjects spoke monosyllabic words under two conditions: (i) normal auditory feedback of their speech, and (ii) auditory feedback in which the first formant frequency of their speech was unexpectedly shifted in real time. Acoustic measurements showed compensation to the shift within approximately 135 ms of onset. Neuroimaging revealed increased activity in bilateral superior temporal cortex during shifted feedback, indicative of neurons coding mismatches between expected and actual auditory signals, as well as right prefrontal and Rolandic cortical activity. Structural equation modeling revealed increased influence of bilateral auditory cortical areas on right frontal areas during shifted speech, indicating that projections from auditory error cells in posterior superior temporal cortex to motor correction cells in right frontal cortex mediate auditory feedback control of speech.

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Section: Implications For Speech Disorderssupporting

confidence: 67%

Neural mechanisms underlying auditory feedback control of speech

2008

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“…Early electroencephalography (EEG) and dichotic listening studies suggest that stuttering speakers tend to have more activity in the right hemisphere of the brain during speech than do non-stuttering speakers (Boberg et al, 1983;Curry and Gregory, 1969;Moore, 1986;Moore and Haynes, 1980). More recent positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) studies have further confirmed these results (e.g., De Nil et al, 2003;Fox et al, 1996Fox et al, , 2000Neumann et al, 2003;Preibisch et al, 2003;Wu et al, 1995). Although these results may lead one to believe that the right hemisphere is related to stuttering, a now-classic study by Braun et al (1997) revealed that activation in the right hemisphere was related to fluent speech among stuttering speakers, whereas activation in the left hemisphere was related to the production of stuttered speech.…”

Section: Introductionmentioning

confidence: 77%

“…1) is the neural network involved in stuttering. Previous research showed that stuttering and non-stuttering speakers differ significantly in activation patterns in the BGTC, especially in the left frontal motor cortex, the temporal cortex, and the basal ganglia (e.g., Braun et al, 1997;Brown et al, 2005;De Nil et al, 2003;Fox et al, 1996;Giraud et al, 2008;Ingham et al, 2000). Within the frontal motor cortex, the supplementary motor area (SMA, including both the SMA proper and anterior supplementary motor area -preSMA) may play a special role.…”

Section: Introductionmentioning

confidence: 99%

Altered effective connectivity and anomalous anatomy in the basal ganglia-thalamocortical circuit of stuttering speakers

Peng

Chen

et al. 2010

Cortex

142

107

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“…The motor group specifies the task to be performed by each subsystem, but does not specify how performance of these tasks should proceed. This is because, depending on the configuration constancy of changes in the peripheral speech mechanisms (i.e., during connected, and therefore fluent, speech), the task may be performed via different paths, some of which may be more efficient than others (16,(19)(20)(21)(22)(23) .…”

Section: Introductionmentioning

confidence: 99%

Aspectos da fluência da fala em crianças com distúrbio específico de linguagem

Andrade

Befi-Lopes

Juste

et al. 2014

Audiol., Commun. Res.

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Purpose: The present study aimed to assess specific aspects of speech fluency in children with specific language impairment (SLI). This included examining the typology of speech disruption and rate (in words and syllables per minute), across different age groups. Methods: A total of 50 children, aged 3 to 7 years old, presenting with nonverbal IQ and hearing thresholds within normal limits (without the presence of stuttering) participated in the study. Children were divided into two groups: G1 (SLI) included 25 children (7 girls and 18 boys) and G2 that children aged 3 to 4 years old in G1 had lower speech rate than their age-matched peers from G2. Within-group analyses revealed no differences in disruption typologies between age groups in G1 participants. In contrast, hesitation was the most frequent typology for 4-to 5-year-old G2 children, whereas hesitation and word repetition typologies were observed in 6-to 7-year-old G2 children. Conclusion: Children with suspected SLI between the ages of 3 to 4 years old showed a reduction in word and syllable production. Hesitation-type speech disruptions were prominently used by typically developing children, regardless of age, and were not observed in SLI children.

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A positron emission tomography study of short- and long-term treatment effects on functional brain activation in adults who stutter

Cited by 124 publications

References 22 publications

Neural mechanisms underlying auditory feedback control of speech

Neural mechanisms underlying auditory feedback control of speech

Altered effective connectivity and anomalous anatomy in the basal ganglia-thalamocortical circuit of stuttering speakers

Aspectos da fluência da fala em crianças com distúrbio específico de linguagem

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