2019
DOI: 10.1371/journal.pone.0217423
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A possible association between statin use and improved Clostridioides difficile infection mortality in veterans

Abstract: Clostridioides difficile infection (CDI) is the most common cause of nosocomial diarrhea and places a significant burden on patients and the health care system. Statins could lead to improvements in CDI clinical response due their pleiotropic effects, including immunomodulatory and lipid-lowering effects; however, few studies have assessed this association. The primary objective of this study was to compare CDI health outcomes in statin users and non-users in a national cohort of patients. This was … Show more

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Cited by 6 publications
(6 citation statements)
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“…A dedicated search for prophylaxis resulted in 290 additional references of which 11 were assessed in more detail; one extra study was included for prophylaxis [30], and one for CDI therapy [31]. The prognostic search on severe CDI yielded 1242 references; 126 studies were assessed in more detail and 76 were included for analysis [29,; 12 more studies were manually added from cross-references [107][108][109][110][111][112][113][114][115][116][117][118] resulting in 88 studies for final analysis. The prognostic search on recurrent CDI yielded 1104 references; 105 studies were assessed in more detail and 36 were included for analysis [99,106,; seven cross-references were added [25,108,[153][154][155][156][157], resulting in 43 studies for final analysis.…”
Section: Resultsmentioning
confidence: 99%
“…A dedicated search for prophylaxis resulted in 290 additional references of which 11 were assessed in more detail; one extra study was included for prophylaxis [30], and one for CDI therapy [31]. The prognostic search on severe CDI yielded 1242 references; 126 studies were assessed in more detail and 76 were included for analysis [29,; 12 more studies were manually added from cross-references [107][108][109][110][111][112][113][114][115][116][117][118] resulting in 88 studies for final analysis. The prognostic search on recurrent CDI yielded 1104 references; 105 studies were assessed in more detail and 36 were included for analysis [99,106,; seven cross-references were added [25,108,[153][154][155][156][157], resulting in 43 studies for final analysis.…”
Section: Resultsmentioning
confidence: 99%
“…The search for prognostic factors for sCDI yielded 1242 references; 126 studies were assessed in more detail and 76 were included for analysis [20,24,25,29,; twelve more studies retrieved from cross-references were also included [111][112][113][114][115][116][117][118][119][120][121][122] resulting in 88 studies for final analysis (Figure 1). The search for prognostic factors for rCDI yielded 1104 references; 105 studies were assessed in more detail and 36 were included for analysis [9, 10, 12-15, 103, 110, 123-150] as were seven studies from cross-references.)…”
Section: Resultsmentioning
confidence: 99%
“…A following step would be to test if anti-inflammatory interventions, in particular those that cross the blood-brain barrier (BBB) vs. those that do not cross the BBB, will normalize the effect of the hypersensitivity to stressors, in parallel with TSPO binding. Broadly prescribed treatments that have an immunomodulatory effect, such as statins, could be used, as they have been shown to have major benefits in reducing severe outcomes in severe infections [210][211][212][213][214][215][216][217] with advantageous effects of statins emerging from both pretreatment [210,211,213,214,216,217] as well as continuation [211][212][213]217] paradigms. Experimentally, statins have been shown to reduce microglia and astrocyte activation after controlled cortical impact injury [218].…”
Section: Future Research and Clinical Considerationsmentioning
confidence: 99%