A Possible Dual Control Mechanism in the Origin of Peptic Ulcer

Oi, Minoru; Ito, Yoriko; Kumagai, Fumiya; Yoshida, Kan; Tanaka, Yoshiki; Yoshikawa, Keiichi; Miho, Otomi; Kijima, M.

doi:10.1016/s0016-5085(19)33901-0

Cited by 91 publications

(8 citation statements)

References 3 publications

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“…We suggest that phospholipid‐related protection is strong in the fundic gland mucosa, but is impaired in the pyloric gland mucosa. The findings of the present study agree with the fact that gastric ulcers almost never develop in the fundic gland mucosa 34 …”

Section: Discussionsupporting

confidence: 92%

Changes in Mucosal Phospholipid‐related Protection in Some Gastric Diseases

Matsuda

Misumi

Murakami

et al. 2003

Digestive Endoscopy

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Background: Phospholipids play an important role in gastric mucosal protection. The purpose of the present study was to investigate changes in various phospholipids in the fundic and pyloric gland mucosae of patients with gastric mucosal disease. Methods: One hundred and five patients with superficial gastritis, duodenal ulcer, gastric ulcer or gastric cancer were studied. Patients underwent endoscopy to obtain biopsy specimens from both the fundic and pyloric gland mucosae. The phospholipid contents were measured by high performance liquid chromatography. Results: Total phospholipid level was significantly greater in the fundic gland mucosa than in the pyloric gland mucosa (P = 0.037), and the level in the fundic gland mucosa was high in all four gastric diseases studied. The difference was significant in patients with gastric ulcers (P = 0.0156). Total phospholipid levels were the highest in superficial gastritis, followed by duodenal ulcer, gastric ulcer and gastric cancer. In all four gastric diseases, phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC) levels were high, while phosphatidylinositol, lysophosphatidylcholine, and sphingomyelin levels were low. The PE and PC levels were higher in the fundic gland mucosa than in the pyloric glandular mucosa, whereas the PS level was higher in the pyloric gland mucosa than in the fundic gland mucosa. Conclusions: The fundic gland mucosa has stronger phospholipid‐related protection than the pyloric gland mucosa, based on the levels of mucosal phospholipids. The main phospholipids for gastric mucosal protection are PC and PE (in the fundic gland mucosa) and PS (in the pyloric gland mucosa). Phospholipid‐related protection is strong in superficial gastritis and duodenal ulcer, but is reduced in the pyloric gland mucosa in patients with gastric ulcers, and in both gastric gland mucosae in patients with gastric cancer.

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Section: Discussionsupporting

confidence: 92%

Changes in Mucosal Phospholipid‐related Protection in Some Gastric Diseases

Matsuda

Misumi

Murakami

et al. 2003

Digestive Endoscopy

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“…A correlation of at least 95% is uncommon for any biological phenomenon. It points to the possibility of a causal relationship between the localisation and the nature of the lesion which we have yet to demonstrate 15,19 .…”

Section: Introductionmentioning

confidence: 72%

“…Their position seems to vary with the patient’s age 13 . Circumferentially, the ulcer is generally limited to the lesser curvature of the stomach 14,15 . The longitudinal position of gastric ulcers tends to shift to a more proximal location with increasing age.…”

Section: Introductionmentioning

confidence: 99%

A Differential Approach to Form and Site of Peptic Ulcer

Rau

Hohaus²,

Jessen³

2019

Sci Rep

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The structural organization of intestinal blood flow is such as to allow for intramural collateral flow. Redistribution phenomena due to different local metabolic demands may lead to an impaired perfusion of parts of the intestinal wall which will display a characteristic pattern. Based on Ohm’s and Kirchhoff’s laws, a differential analysis of the gastric vascular bed bridges the gap between basic physiological concepts and traditional anatomical, pathological and clinical knowledge. An ulcer of the intestinal wall becomes understandable as a non-occlusive infarct based on a supply/demand conflict in an anisotropic structure as it can be found in the upper and lower gastrointestinal tract of man.

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“…For this test ulcer locations were divided into five ordered regions: proximal stomach (location 1-25), antrum (26)(27)(28)(29)(30)(31)(32)(33)(34)(35), pyloric region (36-40), proximal duodenal bulb (41-45) and distal duodenal bulb (46-50). For each patient the number of ulcers at each site were calculated.…”

Section: Discussionmentioning

confidence: 99%

Profound spatial clustering of simultaneous peptic ulcers.

Cappell

1989

Gut

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A Possible Dual Control Mechanism in the Origin of Peptic Ulcer

Cited by 91 publications

References 3 publications

Changes in Mucosal Phospholipid‐related Protection in Some Gastric Diseases

Changes in Mucosal Phospholipid‐related Protection in Some Gastric Diseases

A Differential Approach to Form and Site of Peptic Ulcer

Profound spatial clustering of simultaneous peptic ulcers.

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