A possible homology between immunodeficiency virus p24 core protein and picornaviral VP2 coat protein: prediction of HIV p24 antigenic sites.

Abstract

With the use of a sensitive sequence comparison algorithm, a homology has been suggested between the primary structures of simian immunodeficiency virus (SIV) p24 core protein and foot‐and‐mouth disease virus (FMD) VP2 coat protein. Since the FMD sequence is homologous to picornaviral VP2 sequences with known three‐dimensional architecture and since the SIV p24 sequence can be convincingly aligned with that from human immunodeficiency virus (HIV), it was possible to predict an eight‐stranded beta‐barrel fold for the HIV core protein. From analogy with the known environments of the picornaviral coats, p24 sequence spans could be predicted as likely candidates for antibody attachment. These suggestions may be important for development of an AIDS vaccine.

Spectroscopic study of an HIV‐1 capsid protein major homology region peptide analog

“…2A. This result is in disagreement with prior predictions as to the tertiary structure of HIV-l CA via sequence alignment with picornaviral proteins [15], in which it was suggested that residues tyrosine-17 through threonine-24 of the peptide analog form a B-strand in the CA protein.…”

Causes of false-positive HIV rapid diagnostic test results

“…Picornaviruses are reported to be widespread and cause annual occurrences of gastrointestinal and respiratory influenza [59]. Some studies suggest a possible homology between HIV and picornviral proteins [100] but there appears to be no evidence this is a cause of HIV false positives  Pregnancy Historic; publications related to first-generation immunoassay only [66]  Retroviruses: bovine, caprine, feline…”

Location of epitopes on the major core protein p24 of human immunodeficiency virus

“…With this method overlapping nonapeptides covering the complete amino acid sequence of p24 of HIV-1 were tested for their reactivity with polyclonal antibodies and monoclonal antibodies raised against viral lysate, as well as with patients' sera. The detected antibody-binding sites were superimposed on a structural model of p24, recently proposed by Argos (1989). This model is based upon the homology between p24 of HIV and the coat protein VP2 of the picornaviruses (Argos, 1989).…”

“…The detected antibody-binding sites were superimposed on a structural model of p24, recently proposed by Argos (1989). This model is based upon the homology between p24 of HIV and the coat protein VP2 of the picornaviruses (Argos, 1989). The results show that the antibody-binding sites are located largely on loops, turns and coils of p24.…”