A possible role of myofibroblast in biological behavior of odontogenic keratocyst and ameloblastoma: A comparative study

Shruthi, D K; Tegginamani, Anand S; Karthik, B

doi:10.4103/2249-9725.132977

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings confirm to Smith et al who reported a recurrent infiltrative ameloblastoma whose stroma contained abundant MFs and concluded that these cells accompany the invasive behavior of this tumor. A similar study was carried out by Shruthi et al [27] to assess the frequency of stromal MFs in odontogenic keratocyst (OKC) and ameloblastomas and to correlate the same with the behavior of these lesions, where they found that the mean number of MFs in ameloblastoma was more than that of OKC. Even they found a positive link between the presence and number of MFs to the aggressive behavior of the odontogenic cyst/tumor.…”

Section: Discussionmentioning

confidence: 85%

Immunohistochemical expression of myofibroblasts using alpha-smooth muscle actin (SMA) to assess the aggressive potential of various clinical subtypes of ameloblastoma

Mudaliar

Tamgadge

et al. 2019

J Microsc Ultrastruct

View full text Add to dashboard Cite

Objective:Ameloblastoma is a rare odontogenic neoplasm with high recurrence rates if improperly treated. If left untreated (or is treated inadequately), it can cause substantial morbidity, disfigurement, and even death. Hence, there is a need to explore the stromal cells too, which might play an important role in assessing its aggressive behavior and may help to predict the recurrence of different clinical variants of ameloblastoma. Myofibroblasts (MFs) are such cells which have been studied in various lesions.Materials and Methods:This retrospective study involved archival tissues of ameloblastoma. Among a total of 40 cases, 12 cases of SMA (solid multicystic ameloblastoma), 10 cases of unicystic ameloblastoma (UA), 8 cases of desmoplastic ameloblastoma, and 10 cases of oral squamous cell carcinoma were selected as control. Immunohistochemical staining with anti-alpha-smooth muscle actin antibody was done. Interpretation of ten examined fields was counted by three observers.Results:Significant difference in the number of MFs in SMA and UA and desmoplastic ameloblastoma and UA (P < 0.05) was found. However, there was no statistically significant difference in MFs of SMA and desmoplastic ameloblastomas (P > 0.05). In addition, there was no statistically significant difference in the staining intensity between the three variants (P > 0.05).Conclusion:A significant correlation was obtained between the number of MF in all the three clinical variants, i.e., SMA, UA, and desmoplastic ameloblastoma (P = 0.02), which is the unique feature of the study.

show abstract

Section: Discussionmentioning

confidence: 85%