A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin.

Fujiwara, Suguru; Imai, Junta; Fujiwara, Mineko; Yaeshima, Tomoko; Kawashima, Takuji; Kobayashi, Kinji

doi:10.1016/s0021-9258(19)38596-5

Cited by 314 publications

(76 citation statements)

References 33 publications

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“…It is stable at low pH and high temperature due to its disulfide bonds in its structure (Barnuţiu et al, 2011). Royalisin prevents microbial contamination in royal jelly for Gram-positive bacteria, especially (Fontana et al, 2004 Simuth, 2001;Fujiwara et al, 1990;Maghsoudlou et al, 2019;Scarselli et al, 2005).…”

Section: Peptidesmentioning

confidence: 99%

Royal Jelly: Proteins and Peptides

Yükünç

2020

Journal of Apitherapy and Nature

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Royal jelly is secreted by the hypopharyngeal and mandibular glands of 5-15 days worker honeybees (Apis mellifera). Royal jelly is a thick and milky bee product with high nutritional value. Besides the nutritional functions on queen and worker larvaes, it also has a very important role on the specific functions of queen bees. Due to its important biological properties, royal jelly has been used in the pharmaceutical, food and cosmetics industry especially for the last 50-60 years as a functional and nutraceutical food. The studies have shown that royal jelly has antioxidant, antidiabetic, antitumor, neurotrophic, antimicrobial, anti-inflammatory, hypotensive, hepatoprotective, antihypercholesterolemic, hypoglycaemic and effects on the reproductive system and fertility. These activities are attributed to the bioactive components it contains such as major royal jelly proteins (MRJPs), jelleins and royalisin peptides and 10-hydroxy-2-decenoic acid (10-HDA). Especially MRJPs are considered an important factor in the development of queen bees. The aim of this study is to summarize and update physicochemical and bioactive properties of royal jelly, characterization and functions of royal jelly proteins (RJPs) and peptides.

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Section: Peptidesmentioning

confidence: 99%

Royal Jelly: Proteins and Peptides

Yükünç

2020

Journal of Apitherapy and Nature

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“…A major property of linear peptides in venoms appears to be antimicrobial activity and it is has been proposed they may protect venom glands from microbial infection [151], although this seems unlikely in the case of spiders [152]. In communal arthropods such as ants and bees, antimicrobial excretions may protect the colony from pathogens and prevent fungal and bacterial outbreaks in the nest or hive [153,154].…”

Section: Linear Peptidesmentioning

confidence: 99%

The insecticidal potential of venom peptides

Smith

Herzig

King

et al. 2013

Cell. Mol. Life Sci.

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Pest insect species are a burden to humans as they destroy crops and serve as vectors for a wide range of diseases including malaria and dengue. Chemical insecticides are currently the dominant approach for combating these pests. However, the de-registration of key classes of chemical insecticides due to their perceived ecological and human health risks in combination with the development of insecticide resistance in many pest insect populations has created an urgent need for improved methods of insect pest control. The venoms of arthropod predators such as spiders and scorpions are a promising source of novel insecticidal peptides that often have different modes of action to extant chemical insecticides. These peptides have been optimized via a prey-predator arms race spanning hundreds of millions of years to target specific types of insect ion channels and receptors. Here we review the current literature on insecticidal venom peptides, with a particular focus on their structural and pharmacological diversity, and discuss their potential for deployment as insecticides.

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“…Because of the presence of a variety of biologically active compounds, such as free amino acids, simple sugars, proteins, short chain hydroxy fatty acids, trace elements and vitamins, RJ is believed to be a functionally active supplement, not only for the bees but also for humans. [1][2][3] In addition to its use as a dietary supplement, RJ has been reported to be associated with many health-promoting properties, [4][5][6][7][8][9] such as cancer prevention, cholesterol reduction and wound healing, as well as anti-fatigue, antihypertensive and antibacterial effects. In addition to these physical effects, several reports have also interestingly postulated that RJ has immunomodulatory activities.…”

Section: Introductionmentioning

confidence: 99%

Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB × NZW F1 mice

Mannoor

Shimabukuro

Tsukamotoa

et al. 2009

Lupus

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Royal jelly (RJ) is a gelatinous secretion from young nurse worker bees (Apis mellifera), which serves as the sole food for the queen bee. Because of its pleiotropic functions for queen bees, RJ has also been used as a dietary supplement with various health benefits for humans. Because RJ is being indicated to have immunomodulatory potential for humans, we undertook the study to determine whether the oral administration of RJ could alter the development of systemic autoimmunity in New Zealand Black (NZB) x New Zealand White (NZW) F1 mice that genetically exhibit many manifestations similar to human systemic lupus erythematosus (SLE). We herein reported that mice administered with RJ showed a significant delay in the onset of the disease, as manifested by decreased proteinuria and a prolongation of lifespan. In addition, RJ administration after the onset of the disease significantly improved the renal symptoms, leading to an extended lifespan. RJ administration to mice caused a significant decrease in the serum level of IL-10, and in the autoantibodies against ssDNA, dsDNA and erythrocytes, as well as a reduction in the number of splenic autoreactive B cells. In conclusion, our data suggest that the use of RJ may be beneficial in the prevention of the early onset of SLE and in the control of the active progression of the manifestations of SLE.

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A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin.

Cited by 314 publications

References 33 publications

Royal Jelly: Proteins and Peptides

Royal Jelly: Proteins and Peptides

The insecticidal potential of venom peptides

Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB × NZW F1 mice

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