Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB × NZW F1 mice

Mannoor, MK; Shimabukuro, Isao; Tsukamotoa, M; Watanabe, Hirotaka; Yamaguchi, Kengo; Sato, Yoshiya

doi:10.1177/0961203308094765

Cited by 29 publications

(24 citation statements)

References 22 publications

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“…RJ is known to have multipotent health beneficial actions; the immunomodulatory effects in particular are being increasingly proven in the literature (9). RJ was found to stimulate antibody production and immunocompetent cell proliferation in mice (14).…”

Section: Discussionmentioning

confidence: 99%

“…Mice that received RJ showed decreased proteinuria and a prolongation of lifespan. RJ caused a significant decrease in the serum level of IL-10, and in the autoantibodies against ssDNA, dsDNA, and erythrocytes, as well as a reduction in the number of splenic autoreactive B cells (9). …”

Section: Discussionmentioning

confidence: 99%

“…Based on unique composition of RJ, recently in vivo and in vitro studies focused on its health-promoting characteristics such as hypotensive, anti-hypercholesterolemia, anti-inflammatory, antitumor, antioxidant and weight management effects and immunomodulatory properties (9, 10). The immunomodulatory properties were approved in animal studies of SLE, as RJ administration to mice caused a significant decrease in the serum level of IL-10 and in the autoantibodies against single-stranded deoxyribonucleic acid (ssDNA), double-stranded deoxyribonucleic acid (dsDNA), and erythrocytes, as well as a reduction in the number of splenic autoreactive B cells (9). We hypothesized that RJ has a role in controlling the disease activity of SLE through its immunomodulatory effect on Tregs.…”

mentioning

confidence: 99%

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Effects of royal jelly supplementation on regulatory T cells in children with SLE

Zahran

Elsayh

Saad

et al. 2016

Food & Nutrition Research

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Background and objectiveTo our knowledge, no previous studies have focused on the immunomodulatory effects of fresh royal jelly (RJ) administration on systemic lupus erythematosus (SLE) in humans. Our aim was to study the effect of fresh RJ administration on the disease course in children with SLE with some immunological markers (CD4+ and CD8+ regulatory T cells and T lymphocytes apoptosis).MethodsThis was an open-label study in which 20 SLE children received 2 g of freshly prepared RJ daily, for 12 weeks.ResultsThe percentages of CD4+ CD25+high FOXP3+cells (CD4+ regulatory T cells) and CD8+CD25+high FOXP3+cells (CD8+ regulatory T cells) were significantly increased after RJ treatment when compared with baseline values. Apoptotic CD4 T lymphocytes were significantly decreased after RJ therapy when compared with baseline values and the control group.ConclusionThis is the first human study on the effect of RJ supplementation in children with SLE. Our results showed improvements with 3-month RJ treatment with regard to the clinical severity score and laboratory markers for the disease. At this stage, it is a single study with a small number of patients, and a great deal of additional wide-scale randomized controlled studies are needed to critically validate the efficacy of RJ in SLE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of royal jelly supplementation on regulatory T cells in children with SLE

Zahran

Elsayh

Saad

et al. 2016

Food & Nutrition Research

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“…Royal Jelly is a hive product rich in bioactive compounds with various biological properties and effects: antioxidative (Guo et al, 2005(Guo et al, , 2009Jamnik et al, 2007;Silici et al, 2009; DelkhosheKasmaie et al, 2014), antiaging (Inoue et al, 2003), tonic (Fossati, 1972), antimicrobial (Fontana et al, 2004;Romanelli et al, 2011), immunomodulatory (Mannoor et al, 2009), anti-inflammatory (Kohno et al, 2004(Kohno et al, , 2015, neurotrophic, hypoglicaemic, hypocholesterolaemic (Kamakura et al, 2006;Kashima et al, 2014), vasodilative (Tokunaga et al, 2004), antitumoral, anti-allergic (Okamoto et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Quality Parameters for Commercial Royal Jelly

Mureșan¹,

MÄƒrghitaÈ²,

Dezmirean³

et al. 2016

BUASVMCN-ASB

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Royal jelly has become a high-value commercial product and the standardization of this product is required to guarantee its quality on the market. The objective of the research activity was to pursue the chemical composition of commercial samples of Royal Jelly in Romania in order to propose standardization for this product. The physicochemical composition of commercial Royal Jelly samples was analysed by determining quality parameters like: carbohydrates, lipids, proteins, 10-hydroxy-2-decenoic acid (10-HDA) and mineral elements. Carbohydrates analysis showed values between 3.4 % and 5.87 % for fructose, 4.12 % and 7.05 % for glucose, while for sucrose the values ranged between 0.95 % and 2.56 % (determined by HPLC-RI). The lipids content ranged between 1.85 % and 6.32 % (determined by the Soxhlet method). The protein values extended from 13.10 % (RJ2) to 17.04 % (RJ10) (the total protein content was determined by the Kjeldahl method). The values for the major fatty acid in Royal Jelly, 10-HDA, ranged between 1.35 % (RJ8) and 2.03 % (RJ10) (determined by high-performance liquid chromatography). The concentration of minerals varied between 3188.70 mg/kg and 4023.39 mg/kg (the concentration of minerals was measured using flame atomic absorption spectrometry). Potassium, followed by magnesium, sodium and calcium, occurs in the highest concentrations. The commercial Royal Jelly samples analysed presented variable physico-chemical characteristics that correspond with the values given by international quality standard proposals for Royal Jelly.

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“…Various mouse SLE models have been applied to investigate this disease, including spontaneous models, such as NZB × NZW F1, MRL-lpr/lpr mice, and drug-induced models. [12][13][14][15][16] 2, 6, 10, 14tetramethylpentadecane (TMPD), which is also known as pristine, has been widely used to induce murine models of SLE. [17][18][19][20] TMPDtreated mice show many clinical features of human lupus, including glomerulonephritis, arthritis, immune complex deposition, and autoantibody production.…”

Section: Introductionmentioning

confidence: 99%

E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis

Bao

Chen

et al. 2018

Cell Mol Immunol

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, and the pathogenesis of SLE has not been fully elucidated. The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and subsequent degradation of various oncoproteins; however, the potential role of FBXW7 in autoimmune diseases is unclear. In the present study, we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2, 6, 10, 14-tetramethylpentadecane (TMPD). Myeloid cell-specific FBXW7-deficient (Lysm + FBXW7 f/f ) C57BL/6 mice showed decreased immune complex accumulation, glomerulonephritis, glomerular mesangial cell proliferation, and basemembrane thickness in the kidney. Lysm + FBXW7 f/f mice produced fewer anti-Sm/RNP and anti-ANA autoantibodies and showed a decreased MHC II expression in B cells. In Lysm + FBXW7 f/f mice, we observed that cell apoptosis was reduced and that fewer CD11b + Ly6C hi inflammatory monocytes were recruited to the peritoneal cavity. Consistently, diffuse pulmonary hemorrhage (DPH) was also decreased in Lysm + FBXW7 f/f mice. Mechanistically, we clarified that FBXW7 promoted TMPD-induced cell apoptosis by catalyzing MCL1 degradation through K48-linked ubiquitination. Our work revealed that FBXW7 expression in myeloid cells played a crucial role in TMPD-induced SLE progression in mice, which may provide novel ideas and theoretical support for understanding the pathogenesis of SLE.

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Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB × NZW F1 mice

Cited by 29 publications

References 22 publications

Effects of royal jelly supplementation on regulatory T cells in children with SLE

Effects of royal jelly supplementation on regulatory T cells in children with SLE

Quality Parameters for Commercial Royal Jelly

E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis

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