A potent non-steroidal anti-inflammatory agent: 2-[3-chloro-4(3-pyrrolinyl)phenyl]propionic acid

Effect of C 21 524-Su (Pirprofen) on Spontaneous Osteoarthrosis in the Mouse

“…It has also been shown to inhibit the biotransport of prosta glandin in vitro (3). By virtue of these proper ties, and especially in view of favourable reports concerning its therapeutic ratio (5) and gastro intestinal toxicity (6) in animals, and its gastric tolerability (6) and physiological disposition (1,15) in man, C 21 524-Su can be expected to produce beneficial effects in the treatment of Since it also appeared likely that the compound might be effective in the systematic treatment in the very much more common degenerative forms of rheumatism, the way in which its chronic administration influences the develop ment of osteoarthrosis demanded closer in vestigation.…”

“…Preparation C 21 524-Su (pirprofen: 2-[3-chloro-4(3-py rrolinyl)-phenyl ]-propionic acid) displays antinociceptive and anti-inflam matory activity in experimental models of acute and chronic inflammation (5,7,10) and has a potent, but reversible inhibitory effect on prostaglandin synthetase in vitro (11)(12)(13) and in vivo (2,13). It has also been shown to inhibit the biotransport of prosta glandin in vitro (3).…”

Synthesis of aryl-2-propionic acids by electrocarboxylation of methyl aryl bromides

“…Precursors of flunoxaprofen (2-(4-fluorophenyl)-α-methyl-5-benzoxazole bromide) and pirprofen (3-chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-α-methyl benzyl bromide) were prepared according to the published procedure. 17,18 Electrochemical carboxylation was carried out in an undivided cell equipped with a platinum cathode and magnesium anode. The cell was charged with 50 mL of dimethylformamide (DMF) solution containing reagent grade 0.04 M tetrabutylammonium iodide (Bu 4 NI) and 2-(4-fluorophenyl)-α-methyl-5-benzoxazole bromide (20 mmol) was added to the cell.…”

Use of tellurium(IV) and tellurium(VI) as oxidants in organic synthesis

“…The use of Te02 as an oxidant in organic synthesis was tentatively explored as early as the 1940's. 1 The results, (1) Fischer, C. H.; Eisner, A. J. Org. Chem.…”