Effect of C 21 524-Su (Pirprofen) on Spontaneous Osteoarthrosis in the Mouse

Wilhelmi, G

doi:10.1159/000136778

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…Pirprofen had previously shown significant activity in our rabbit model of OA wh&n administered orally (2), and it also exerted activity in a spontaneous mouse model of OA (23). The lack of activity of IA pirprofen may be due to the great water solubility of the compound, i.e., it may be leached out of the joint soon after injection.…”

Section: Discussionmentioning

confidence: 98%

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A new model of osteoarthritis in rabbits

Butler¹,

Colombo²,

Hickman³

et al. 1983

Arthritis & Rheumatism

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A battery of steroidal and nonsteroidal antirheumatic drugs and protease inhibitors were tested by intraarticular injection for effects on osteoarthritis of the knees of rabbits subjected to partial lateral meniscectomy and section of the sesamoid and collateral fibular ligaments. Among the standard drugs, only the glucocorticoid, triamcinolone hexacetonide, and the protease inhibitor, tranexamic acid, exhibited significant anti-osteoarthritic activity. An experimental drug, GPA 2163, also offered some protection against joint degeneration. The nonsteroidal antiinflammatory drugs had no effect on the development of osteoarthritis in the model.In a previous report from this laboratory, a new surgical method for experimental induction of osteoarthritis (OA) in rabbits was described (1). This method, which involves partial lateral meniscectomy and section of the sesamoid and collateral ligaments, induces a relatively consistent and reproducible degenerative disease of rabbit knees in a period of 6 weeks. A battery of selected steroidal drugs, nonsteroidal antiinflammatory drugs (NSAIDs), and other drugs reputed to possess antirheumatic properties or otherwise influence connective tissues have subsequently been tested for systemic efficacy in retarding or reversing the cartilage deterioration in knees of rabbits subjected to the new procedure (2). A few drugs exerted marked to moderate anti-OA activity. These included the steroids, paramethasone and triamcinolone, only 2 of 11 NSAlDs tested (pirprofen and the experimental drug, CGS 5391B), the glucofuranoside derivative, tribenoside, and the anti-estrogen, tamoxifen. The anti-osteoarthritic activity could not be explained in terms of known antiinflammatory or other properties of these drugs.In the present study, additional selected drugs have been tested for possible anti-OA efficacy by direct intraarticular (IA) injection in laterally meniscectomized rabbits. MATERIALS AND METHODSMale New Zealand white rabbits (Hare Farms) weighing approximately 4 kg each were subjected to partial lateral meniscectomy with section of the fibular collateral and sesamoid ligaments or sham operation, as previously described (1). The animals were maintained on a diet of standard rabbit pellets and tap water ad libitum.Intraarticular injections into the knee joint of test drugs or vehicle were given either as a single 0.0s ml dose 7 days post-surgery or as two 0.05 ml doses on days 7 and 14 post-surgery. The injections were made using 0.25-ml glass syringes and 26-gauge one-half-inch needles for soluble drugs or 23-gauge one-half-inch needles for suspensions. The source, dosage, and vehicle used for each test drug are shown in Table 1. One drug, triamcinolone hexacetonide, was also injected periarticularly (PA) in one group of rabbits (i.e., the compound was injected into the soft tissue immediately adjacent to the knee joint).In each rabbit tested, the right (operated) knee was injected with drug, while the left (unoperated) knee was injected with vehicle only, as a test for possible i...

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Section: Discussionmentioning

confidence: 98%

“…The injections were made using 0.25-ml glass syringes and 26-gauge one-half-inch needles for soluble drugs or 23 were injected intraarticularly with sterile water, the most commonly used vehicle.…”

Section: Methodsmentioning

confidence: 99%

A new model of osteoarthritis in rabbits

Butler¹,

Colombo²,

Hickman³

et al. 1983

Arthritis & Rheumatism

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“…Inflammatory cells: (i) zero to two inflammatory cells/mm 2 (0 point), (ii) three to 10 inflammatory cells/mm 2 (2 points), (iii) 11–50 inflammatory cells/mm 2 (5 points), and (iv) more than 50 inflammatory cells/mm 2 (10 points). Also quantitative grading of the cartilage of the condylar heads and articular eminences was performed according to a modified Mankin scoring system (18) and a modified Wilhelmi rating system (19), which was used for osteoarthrosis in the human hips or the knee joints. Structure: (i) normal (0 point), (ii) superficial irregularity and erosion (1 point), (iii) defect in the deep cartilage (2 points), and (iv) defect of the entire cartilage extending to the calcified tissue (3 points).…”

Section: Histopathologic Scoresmentioning

confidence: 99%

Histologic evaluation of temporomandibular arthritis induced by mild mechanical loading in rabbits

Fujimura

Kobayashi

Suzuki

et al. 2005

J Oral Pathology Medicine

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“…Alterations of the genes for the type I1 collagen produce arthropathies that closely resemble the primary osteoarthritis in the transgenic mice Metsaranta, 1994). The knee joints of C57BL male mice are affected with spontaneous osteoarthritis by the age of 18 months and the changes are well defined (Pataki et al, 1980;Silberberg and Silberberg, 1941;Wilhelmi, 1978;Wilhelmi and Faust, 1976). There are also estimates of the spontaneous running distances of C57BL mice (Edgar and Dement, 1991;Goodrick, 1978;Lane et al, 1991).…”

Section: Thritis; Runningmentioning

confidence: 99%