Histologic evaluation of temporomandibular arthritis induced by mild mechanical loading in rabbits

Fujimura, Kazuma; Kobayashi, Susumu; Suzuki, Toshikazu; Segami, Natsuki

doi:10.1111/j.1600-0714.2004.00298.x

Cited by 25 publications

(25 citation statements)

References 30 publications

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“…Rather, the duration of dietary manipulation in our study greatly exceeds that of previous investigations and it is well known that cartilage exhibits accelerated degradation in response to elevated and/or repetitive loading (Guerne et al, 1994;Guerne et al, 1995;Bae et al, 1998). Such changes in cartilage composition reflect the early onset and progression of degenerative effects that compromise the structural integrity of a joint (Mankin et al, 1971;Newton and Nunamaker, 1985;Haskin et al, 1995;Kamelchuk and Major, 1995;Ishibashi et al, 1996;Ostergaard et al, 1999;Fujimura et al, 2005). This interpretation is consistent with patterns of change noted for rabbit TMJ ·8.…”

Section: Adaptive Plasticity and Degradation In Masticatory Tissuessupporting

confidence: 87%

Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints

Ravosa

Kunwar

Stock

et al. 2007

Journal of Experimental Biology

151

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SUMMARY Excessive, repetitive and altered loading have been implicated in the initiation of a series of soft- and hard-tissue responses or `functional adaptations' of masticatory and locomotor elements. Such adaptive plasticity in tissue types appears designed to maintain a sufficient safety factor, and thus the integrity of given element or system, for a predominant loading environment(s). Employing a mammalian species for which considerable in vivo data on masticatory behaviors are available, genetically similar domestic white rabbits were raised on diets of different mechanical properties so as to develop an experimental model of joint function in a normal range of physiological loads. These integrative experiments are used to unravel the dynamic inter-relationships among mechanical loading, tissue adaptive plasticity, norms of reaction and performance in two cranial joint systems:the mandibular symphysis and temporomandibular joint (TMJ). Here, we argue that a critical component of current and future research on adaptive plasticity in the skull, and especially cranial joints, should employ a multifaceted characterization of a functional system, one that incorporates data on myriad tissues so as to evaluate the role of altered load versus differential tissue response on the anatomical, cellular and molecular processes that contribute to the strength of such composite structures. Our study also suggests that the short-term duration of earlier analyses of cranial joint tissues may offer a limited notion of the complex process of developmental plasticity, especially as it relates to the effects of long-term variation in mechanical loads, when a joint is increasingly characterized by adaptive and degradative changes in tissue structure and composition. Indeed, it is likely that a component of the adaptive increases in rabbit TMJ and symphyseal proportions and biomineralization represent a compensatory mechanism to cartilage degradation that serves to maintain the overall functional integrity of each joint system. Therefore, while variation in cranial joint anatomy and performance among sister taxa is, in part, an epiphenomenon of interspecific differences in diet-induced masticatory stresses characterizing the individual ontogenies of the members of a species,this behavioral signal may be increasingly mitigated in over-loaded and perhaps older organisms by the interplay between adaptive and degradative tissue responses.

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Section: Adaptive Plasticity and Degradation In Masticatory Tissuessupporting

confidence: 87%

Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints

Ravosa

Kunwar

Stock

et al. 2007

Journal of Experimental Biology

151

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“…The latter, besides, appeared constituted by S100 immunoreactive chondrocytes both in healthy individuals and in patients with chronic degenerative TMJ lesions. In pathological patients with severe disk damage number and morphology of chondrocytes were severely different in comparison to normal tissues 11; chondrocytes, in fact, were more numerous with a rough and thick elongated cytoplasmic processes conferring a dendritic-like appearance. In some instances, dendritic processes were extremely long and consequently their cytoplasm of origin could not be detected in a single section but only on consecutive sections of the same specimen.…”

Section: Discussionmentioning

confidence: 88%

Immunohistochemical Evaluation of Neuroreceptors in Healthy and Pathological Temporo-Mandibular Joint

Favia¹,

Corsalini²,

Venere³

et al. 2013

Int. J. Med. Sci.

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Aim: A study was performed on the articular disk and periarticular tissues of the temporo-mandibular joint (TMJ) with immunohistochemical techniques to give evidence to the presence of neuroreceptors (NRec) in these sites. Methods: The study was carried out on tissue samples obtained from 10 subjects without TMJ disease and from 7 patients with severe TMJ arthritis and arthrosis. We use antibodies directed against following antigens: Gliofibrillary Acidic Protein (GFAP), Leu-7, Myelin Basic Protein (MBP), Neurofilaments 68 kD (NF), Neuron Specific Enolase (NSE), S-100 protein (S-100) and Synaptophysin (SYN). Results: This study revealed that Ruffini's-like, Pacini's-like and Golgi's-like receptors can be demonstrated in TMJ periarticular tissues and that free nervous endings are present in the subsynovial tissues but not within the articular disk. We observed elongated cytoplamic processes of chondrocytes that demonstrated strong S-100 immunoreactivity but they were unreactive with all other antibodies. These cytoplamic processes were more abundant and thicker in the samples obtained from patients with disease TMJ. Conclusion: The results of this study confirm that different Nrec are detectable in TMJ periarticular tissues but they are absent within the articular disk. In the latter site, only condrocytic processes are evident, especially in diseased TMJ, and they might have been confused with nervous endings in previous morphological studies. Nevertheless the absence of immunoreactivity for NF, NSE and SYN proves that they are not of neural origin.

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“…Different species are available, representing a large variety of anatomical models. The TMJ in New Zealand rabbits ( Oryctolagus cuniculus L.) is anatomically and functionally very similar to the human TMJ 3,6,13,18 , which makes them one of the most widely used animals for this type of study. According to Puricelli 14,15 (1997,2009), in the human TMJ the functional force vector in the mandible has a posterior-anterior/ inferior-superior direction, through the condyle towards the articular tubercle of the zygomatic process.…”

Section: Introductionmentioning

confidence: 99%

Histomorphometric analysis of the temporal bone after change of direction of force vector of mandible: an experimental study in rabbits

Puricelli

Ponzoni

Munaretto³

et al. 2012

J. Appl. Oral Sci.

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ObjectivesThe present study aimed at performing a histological evaluation of the response of temporal bone tissue to a change of direction of the force vector of the mandible in relation to the base of the skull. Material and methodsAdult rabbits were assigned into four groups with two control and four experimental animals in each group. Experimental animals underwent surgery, which resulted in a change of direction of the force vector on the right temporomandibular joint. Samples were collected after 15, 30, 60 and 90 days for histological analysis. ResultsIn the two-way analysis of variance, the effect of group and time was statistically significant (p<0.001). Additionally, a statistically significant interaction between group and time was observed (p<0.001). Control animals showed normal growth and development of the temporal region. In the experimental group, the change in direction of the force vector of the mandible induced significant changes in the temporal bone, with a bone modeling process, which suggests growth of this cranial structure. ConclusionsThe methodology used in this experiment allows us to conclude that the change in direction of the force vector of the mandible in relation to the skull base induces remodeling and modeling processes in the temporal bone. The resumption of normal oral functions after bone healing of the mandibular fracture appears to increase cell activation in the remodeling and modeling of the temporal bone structure. The observation of areas of temporal bone modeling shows the relevance of further investigation on the correlation between the joint structures and craniofacial growth and development.

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Histologic evaluation of temporomandibular arthritis induced by mild mechanical loading in rabbits

Abstract: Our results revealed that mild, continuous mechanical loading to the glenoid fossa induces synovitis of the articular capsule, and induces organic changes of the articular cartilage without destroying these tissues.

Cited by 25 publications

References 30 publications

Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints

Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints

Immunohistochemical Evaluation of Neuroreceptors in Healthy and Pathological Temporo-Mandibular Joint

Histomorphometric analysis of the temporal bone after change of direction of force vector of mandible: an experimental study in rabbits

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