Histomorphometric analysis of the temporal bone after change of direction of force vector of mandible: an experimental study in rabbits

Abstract

ObjectivesThe present study aimed at performing a histological evaluation of the response of temporal bone tissue to a change of direction of the force vector of the mandible in relation to the base of the skull. Material and methodsAdult rabbits were assigned into four groups with two control and four experimental animals in each group. Experimental animals underwent surgery, which resulted in a change of direction of the force vector on the right temporomandibular joint. Samples were collected after 15, 30, 60 and 90 days for histological analysis. ResultsIn the two-way analysis of variance, the effect of group and time was statistically significant (p<0.001). Additionally, a statistically significant interaction between group and time was observed (p<0.001). Control animals showed normal growth and development of the temporal region. In the experimental group, the change in direction of the force vector of the mandible induced significant changes in the temporal bone, with a bone modeling process, which suggests growth of this cranial structure. ConclusionsThe methodology used in this experiment allows us to conclude that the change in direction of the force vector of the mandible in relation to the skull base induces remodeling and modeling processes in the temporal bone. The resumption of normal oral functions after bone healing of the mandibular fracture appears to increase cell activation in the remodeling and modeling of the temporal bone structure. The observation of areas of temporal bone modeling shows the relevance of further investigation on the correlation between the joint structures and craniofacial growth and development.

Melorheostotic Bone Lesions Caused by Somatic Mutations in MAP2K1 Have Deteriorated Microarchitecture and Periosteal Reaction

“…The latter is formed when a bony scaffold has to be quickly formed during fetal development, postnatal growth spurt, in callus during fracture healing, or after osteotomy. (19,(42)(43)(44)(45) In contrast, periosteal lamellar bone deposition occurs much more slowly, in agreement with a progression of melorheostotic lesions over years. (44,46,47) Periosteal new bone formation is often viewed as a physiological response to focal insults or systemic condition such as infections, hemorrhages, inflammations (periostitis), osteonecrosis, tumor processes, and malign neoplasms such as Ewing's sarcoma or Caffey's disease.…”

“…In fact, periosteal cells can lay down either highly organized and lowly mineralized lamellar bone as observed in the melorheostotic lesions or highly disorganized and highly mineralized woven bone. The latter is formed when a bony scaffold has to be quickly formed during fetal development, postnatal growth spurt, in callus during fracture healing, or after osteotomy . In contrast, periosteal lamellar bone deposition occurs much more slowly, in agreement with a progression of melorheostotic lesions over years .…”

Puricelli biconvex arthroplasty as an alternative for temporomandibular joint reconstruction: description of the technique and long-term case report

“…The concave and convex shape of the TMJ surfaces causes a concentration of forces in the anterosuperior region [1]. However, the TMJ may have a favorable response to a change in the force vector [14,15]. Therefore, alternative forms of prosthetic devices (e.g., biconvex) may be essential to disperse the vector forces exerted by the masticatory muscles [16,17].…”

Modelos animais utilizados para o estudo da articulação temporomandibular: revisão de literatura

“…O coelho tem sido empregado para realização de métodos cirúrgicos indutores de DTM, como deslocamento anterior de disco, perfuração de disco e fratura condilar. Ainda, tem sido empregado para avaliação de capacidade adaptativa, osteoartrose, tratamentos cirúrgicos e não cirúrgicos da ATM (Artuzi et al, 2016;Artuzi et al, 2020;Embree et al, 2015;Hu et al, 2012;Puricelli et al, 2012;Puricelli et al, 2019;Sato et. al, 2019).…”

“…Diante da complexidade das patologias que envolvem essa articulação e da diversidade de tratamentos clínicos e/ou cirúrgicos empregados, os modelos animais experimentais proporcionam o estudo da patogênese da DTM, o desenvolvimento e o aprimoramento de novas terapêuticas (Angelo et al 2016;Artuzi et al, 2016;Hakim et al, 2020;Puricelli, Ponzoni, Munaretto, Corsetti, & Leite, 2012;Puricelli, Artuzi, Ponzoni, & Quevedo, 2019;Xiang et al, 2021).…”