A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity

Fukuda, Sanae; Nojima, Junzo; Motoki, Yukari; Yamaguti, Kouzi; Nakatomi, Yasuhito; Okawa, Naoko; Fujiwara, Kazumi; Watanabe, Yasuyoshi; Kuratsune, Hirohiko

doi:10.1016/j.biopsycho.2016.05.005

Cited by 77 publications

(73 citation statements)

References 28 publications

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“…Another potential explanation for the decrements in morning energy associated with a higher BMI is that obesity is associated with increases in oxidative stress and metabolic disorders. 55 This hypothesis is supported by recent studies that found an association between higher levels of oxidative stress and higher levels of fatigue in patients with chronic fatigue syndrome 56 and children undergoing treatment for leukemia. 57 …”

Section: Discussionmentioning

confidence: 70%

Common and Distinct Characteristics Associated With Trajectories of Morning and Evening Energy in Oncology Patients Receiving Chemotherapy

Abid

Kober

Smoot

et al. 2017

Journal of Pain and Symptom Management

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Context While energy conservation strategies are recommended in clinical practice guidelines, little is known about changes in energy levels in oncology patients undergoing cancer treatment. Objectives To identify variations in the trajectories of morning and evening energy levels and to determine which characteristics predicted initial levels as well as the trajectories of morning and evening energy. Methods Outpatients receiving chemotherapy (CTX) completed demographic and symptom questionnaires six times over two CTX cycles. Energy was assessed using the Lee Fatigue Scale. Hierarchical linear modeling was used to analyze the data. Results A large amount of inter-individual variability was found in the morning and evening energy trajectories. Patients who lived alone, had child care responsibilities, had a lower functional status, did not exercise on a regular basis, had lower hemoglobin levels, had lower attentional function, higher trait anxiety, and higher sleep disturbance reported lower morning energy levels at enrollment. Variations in the trajectories of morning energy were associated with a higher body mass index and higher levels of morning energy and higher sleep disturbance scores. For evening energy, patients who were female, White, had lower functional status, and had lower attentional function and higher sleep disturbance, reported lower evening energy levels at enrollment. Evening energy levels at enrollment were associated with changes in evening energy over time. Conclusion Patients undergoing CTX experience decrements in both morning and evening energy. The modifiable characteristics associated with these decrements can be used to design intervention studies to increase energy levels in these patients.

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Section: Discussionmentioning

confidence: 70%

Common and Distinct Characteristics Associated With Trajectories of Morning and Evening Energy in Oncology Patients Receiving Chemotherapy

Abid

Kober

Smoot

et al. 2017

Journal of Pain and Symptom Management

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“…A number of studies have attempted to identify a reproducible biomarker for ME [29–33]. In particular, serum or plasma cytokine and chemokine analyses have shown promise, in that several investigators, including our group, have reported clear differences when comparing ME cases to healthy controls [11, 15, 34–36].…”

Section: Discussionmentioning

confidence: 99%

Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis Using a Random Peptide Microarray Differentiates Cases from Controls with High Specificity and Sensitivity

et al. 2016

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Myalgic encephalomyelitis (ME) is a complex, heterogeneous illness of unknown etiology. The search for biomarkers that can delineate cases from controls is one of the most active areas of ME research; however, little progress has been made in achieving this goal. In contrast to identifying biomarkers that are directly involved in the pathological process, an immunosignature identifies antibodies raised to proteins expressed during, and potentially involved in, the pathological process. Although these proteins might be unknown, it is possible to detect antibodies that react to these proteins using random peptide arrays. In the present study, we probe a custom 125,000 random 12-mer-peptide microarray with sera from 21 ME cases and 21 controls from the U.S. and Europe and used these data to develop a diagnostic signature. We further used these peptide sequences to potentially uncover the naturally occurring candidate antigens to which these antibodies may specifically react with in vivo. Our analysis revealed a subset of 25 peptides that distinguished cases and controls with high specificity and sensitivity. Additionally, BLAST (Basic Local Alignment Search Tool) searches suggest these peptides primarily represent human self-antigens and endogenous retroviral sequences and to a minor extent, viral and bacterial pathogens.

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“…Among non-shift workers, blood was collected on a holiday or after work and at rest. The serum level of d-ROMs and biological antioxidant potential ( BAP ) were evaluated 6) . Oxidation and antioxidation activities were measured simultaneously in the serum.…”

Section: Methodsmentioning

confidence: 99%

“…More recently, Fukuda et al 6) reported that oxidative stress and anti-oxidative activity were potential biomarkers for fatigue in patients with chronic fatigue syndrome. Oxidative stress and anti-oxidative activity are associated with a risk of atherosclerosis or coronary heart disease 7,8) .…”

Section: Introductionmentioning

confidence: 99%

Potential objective biomarkers for fatigue among working women

Ebata

Tatsuta

Tatemichi

2017

Journal of Occupational Health

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: Objective :The prediction of health impairment due to work overload is subjectively assessed based on recognized symptoms ; however, objective evaluation is primarily ideal in the field of occupational health. Recently, some biomarkers of autonomic function and/or oxidative stress were reported to be associated with fatigue. This study aimed to preliminarily investigate whether these biomarkers could be objective indicators for fatigue and stress among working women. Method: Participants included 118 full-time female workers (mean age 37.8 years ) , including 55 shift workers. Selfadministered questionnaires, such as visual analog scale (VAS) for general health, a lifestyle questionnaire, SF-8 for health-related quality of life, and K6 for mental health screening, were used. In addition, biomarkers such as acceleration plethysmogram ( APG ) , reactive oxygen metabolites-derived compounds (d-ROMs), and biological antioxidant potential (BAP) were measured. Results: A significant association was observed between BAP and VAS (r=0.482, p<0.01) among shift workers. However, other biomarkers such as APG and d-ROMs were not significantly associated with symptoms. d-ROMs were significantly correlated with age and body mass index. There was a significant negative correlation between BAP and smoking. Results of the APG ( lowfrequency (LF)/high-frequency (HF) ratio) were significantly correlated with BAP, but not with d-ROMs. The LF/HF ratio and BAP for shift workers were significantly higher than those for day-time workers. Conclusions : Our results suggest that APG and BAP are potential objective biomarkers for fatigue among working women, although further follow-up studies are needed to clarify the scope of usefulness of the biomarkers for fatigue.

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A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity

Cited by 77 publications

References 28 publications

Common and Distinct Characteristics Associated With Trajectories of Morning and Evening Energy in Oncology Patients Receiving Chemotherapy

Common and Distinct Characteristics Associated With Trajectories of Morning and Evening Energy in Oncology Patients Receiving Chemotherapy

Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis Using a Random Peptide Microarray Differentiates Cases from Controls with High Specificity and Sensitivity

Potential objective biomarkers for fatigue among working women

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