A potential link between desmoglein 3 and epidermal growth factor receptor in oral squamous cell carcinoma and its effect on cetuximab treatment efficacy

Minabe, Masaki; Akiyama, Yurie; Higa, Kazunari; Tachikawa, Tetsuhiko; Takahashi, Shinichi; Nomura, Takeshi; Kouno, Michiyoshi

doi:10.1111/exd.13920

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…Interlukin-6 is a multifunctional cytokine having a wide range of immunological activities, and it is also a potential mediator in the cancer development. It is known to promote proliferation of OSCC cell lines and on the other hand stabilizes the antibody inhibited growth in vivo (Minabe et al, 2019). OSCC patients were examined to determine the expression of IL-6 and IL-6 receptor.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Oxidative Stress and Inflammatory Markers of Medical Importance in Oral Squamous Cell Carcinoma

Butt

Abbas

Arshad³

et al. 2022

Biol Clin Sci Res J

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There is an increased prevalence of Oral squamous cell carcinoma (OSCC), and it is a well-known human malignant cancer.Oxidative stress markersare helpful in diagnosis andto assess the progression malignancy. The current analysis aimed to determine the altered levels of reactive oxygen species and inflammatory markers in oral squamous cell carcinoma. This research was conducted by the general pathology department of Institute of dentistry, CMH Lahore,from September 17, 2021, to January 17, 2022. Total of sixtyage and sex matched participants were included in the study and further divided into two groups. In study group thirtyconfirmed cases of oral squamous cell carcinoma on pathologywere recruited. Oxidative stress markers were measured and statistically analyses done by using SPSS software version 25. The results showed increase levels of malondialdehyde, 8-hydroxy-2-deoxyguanosine, isoprostanes, interleukin-6 and tumor necrosis factor alpha as compared to the control groups (p= 0.023, 0.001, 0.041, 0.000 and 0.033 respectively). Oxidative stress markers are elevatedlevels of oxidative stress marked are found in patients of OSCC. That may lead to swift progression of disease and may increase mortality rate.

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Section: Resultsmentioning

confidence: 99%

Assessment of Oxidative Stress and Inflammatory Markers of Medical Importance in Oral Squamous Cell Carcinoma

Butt

Abbas

Arshad³

et al. 2022

Biol Clin Sci Res J

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“…In OSCC, there is a potential link between DSG3 and EGFR, and the expression of DSG3 was significantly increased after treatment with cetuximab, an inhibitor of EGFR. Furthermore, high calcium-associated DSG3 induction enhanced the efficacy of cetuximab in cetuximab-low-sensitive cell lines by up to 23% [92]. Differential expression analysis in oral leukoplakia (OL) tissues and OSCC tissues showed mild to severe loss of the DSG3/γcatenin complex and a transition from membranous to cytoplasmic expression, resulting in perinuclear aggregation, which was directly related to the grade of dysplasia [95].…”

Section: Desmosomal Cadherins Act As a Suppressor In Hncmentioning

confidence: 99%

Paradoxical Roles of Desmosomal Components in Head and Neck Cancer

et al. 2021

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Desmosomes are intercellular adhesion complexes involved in various aspects of epithelial pathophysiology, including tissue homeostasis, morphogenesis, and disease development. Recent studies have reported that the abnormal expression of various desmosomal components correlates with tumor progression and poor survival. In addition, desmosomes have been shown to act as a signaling platform to regulate the proliferation, invasion, migration, morphogenesis, and apoptosis of cancer cells. The occurrence and progression of head and neck cancer (HNC) is accompanied by abnormal expression of desmosomal components and loss of desmosome structure. However, the role of desmosomal components in the progression of HNC remains controversial. This review aims to provide an overview of recent developments showing the paradoxical roles of desmosomal components in tumor suppression and promotion. It offers valuable insights for HNC diagnosis and therapeutics development.

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“…[ 32 ] Studies have shown a potential link between DSG3 and EGFR in OSCC as the expression of DSG3 was increased after the treatment with cetuximab, an inhibitor of EGFR. [ 33 ]…”

Section: Introductionmentioning

confidence: 99%

Role of desmosomal components in the initiation and metastasis of oral cancer—A review

Kumar,

Muthukrishnan,

Rama Rao

et al. 2023

Journal of Oral and Maxillofacial Pathology

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Desmosomes are composed of a number of proteins, including cadherins, armadillo proteins and plakoplilins, which are responsible for mediating cell–cell adhesion. Cadherins are transmembrane proteins that bind to each other on adjacent cells, forming a strong adhesive bond between the cells. In normal tissues, desmosomes help to maintain the structural integrity of the tissue by holding the cells together. During carcinogenesis, the structure and function of desmosomes may be altered. For example, in oral cancer, the expression of certain cadherins may be increased, leading to increased cell–cell adhesion and a more cohesive tumour mass. This may contribute to the ability of cancer cells to evade the immune system and resist chemotherapy. In addition to their role in cell adhesion, desmosomes also play a role in cell signaling. The proteins that make up desmosomes can interact with signaling pathways that regulate cell proliferation, migration and survival. Dysregulation of these pathways may contribute to the development and progression of oral cancer. There is also evidence that desmosomes may be involved in the process of invasion and metastasis, which is the spread of cancer cells from the primary tumour to other parts of the body. Cancer cells that have disrupted or abnormal desmosomes may be more likely to migrate and invade other tissues. Overall, desmosomes appear to be important in the development and progression of oral cancer. Further research is needed to fully understand the role of these cell–cell junctions in the disease and to identify potential therapeutic targets.

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A potential link between desmoglein 3 and epidermal growth factor receptor in oral squamous cell carcinoma and its effect on cetuximab treatment efficacy

Cited by 7 publications

References 27 publications

Assessment of Oxidative Stress and Inflammatory Markers of Medical Importance in Oral Squamous Cell Carcinoma

Assessment of Oxidative Stress and Inflammatory Markers of Medical Importance in Oral Squamous Cell Carcinoma

Paradoxical Roles of Desmosomal Components in Head and Neck Cancer

Role of desmosomal components in the initiation and metastasis of oral cancer—A review

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