A Potential Serum Biomarker, Albumin-to-Glutamyltransferase Ratio, Suggests the Severity of Liver Disease

Pan, Nannan; Liu, Jinlian; Deng, Huimin; Zheng, Wenbin; Cui, Shengjin; Wei, Wei; Lan, Xi; Yu, Huijun; Wang, Jing; Xiao, Li

doi:10.7754/clin.lab.2019.190826

Cited by 2 publications

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“…Our data showed that ALB and serum Na + levels were significantly decreased in liver patients with atrial arrhythmia, which may be associated with the development of ascites. In patients with liver cirrhosis, the decrease in serum Na + caused by water and sodium storage, as well as the inversion of the A/G ratio and the subsequent decrease of plasma colloidal osmotic pressure caused by insufficient synthesis of ALB, are all essential factors in the development of ascites ( 36 , 37 ). A prospective clinical study found that BNP, the most sensitive biochemical marker, is associated with the MELD score in Child-Pugh C patients ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Atrial Arrhythmia in Patients With Liver Cirrhosis: A Retrospective Study

Wang

Yang

Chen

et al. 2021

Front. Cardiovasc. Med.

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Background and Objectives: Liver cirrhosis is known to be associated with atrial arrhythmia. However, the risk factors for atrial arrhythmia in patients with liver cirrhosis remain unclear. This retrospective study aimed to investigate the risk factors for atrial arrhythmia in patients with liver cirrhosis.Methods: In the present study, we collected data from 135 patients with liver cirrhosis who were admitted to the Department of Gastroenterology at Shanghai Tongji Hospital. We examined the clinical information recorded, with the aim of identifying the risk factors for atrial arrhythmia in patients with liver cirrhosis. Multiple logistic regression analysis was used to screen for significant factors differentiating liver cirrhosis patients with atrial arrhythmia from those without atrial arrhythmia.Results: The data showed that there were seven significantly different factors that distinguished the group with atrial arrhythmia from the group without atrial arrhythmia. The seven factors were age, white blood cell count (WBC), albumin (ALB), serum Na+, B-type natriuretic peptide (BNP), ascites, and Child-Pugh score. The results of multivariate logistic regression analysis suggested that age (β = 0.094, OR = 1.098, 95% CI 1.039–1.161, P = 0.001) and ascites (β =1.354, OR = 3.874, 95% CI 1.202–12.483, P = 0.023) were significantly associated with atrial arrhythmia.Conclusion: In the present study, age and ascites were confirmed to be risk factors associated with atrial arrhythmia in patients with liver cirrhosis.

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Section: Discussionmentioning

confidence: 99%