A Practical Guide to Patch Testing

Fonacier, Luz

doi:10.1016/j.jaip.2015.05.001

Cited by 51 publications

(34 citation statements)

References 26 publications

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“…1 The principle of patch test (PT) is that in sensi zed individuals, primed an genspecifi c T lymphocytes of the Th1 phenotype circulate throughout the body and are able to recreate a delayedtype hypersensi vity reac on when nonirrita ng concentra ons of the an gen are applied to normal skin. 2,3 The procedure of patch tes ng is not a diffi cult one to perform, but the reading and interpreta on of the PT and establishing their relevance to the individual cases require training and experience. Once the PT is completed, allergens are iden fi ed, and relevance has been established, educa ng the pa ent about the avoidance of exposure is cri cal.…”

Section: Introductionmentioning

confidence: 99%

Patch Testing In Nepalese Population: A Single Center Study From Kathmandu, Nepal

Paudel

Pun

Parajuli

et al. 2019

Nepal J Dermatol Venereol & Leprol

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Introduction: Patch testing is a diagnostic tool used in investigation to identify specific allergens in allergic contact dermatitis (ACD). It helps find the prevalence and the trends of contact sensitization in the community. Objective: To report the two year patch test results from a central hospital in Kathmandu. Materials and Methods: Consecutive consenting patients of suspected ACD were patch tested with an Indian standard Series (Systopic) from June 2014 to August 2016. Results: Out of 141 patients tested, 89 were female (63.12%) and 52 were male (36.88%). Hand eczema was the commonest pattern (53 patients) followed by persistent and recurrent eczema (44 patients) and face eczema (25 patients). Fifty- five patients (39%) had at least 1 positive allergic reaction. Among these, 16.31% were male and 22.70% were female. The most common allergen was nickel sulfate (19.9%) followed by fragrance mix (7.8%) and paraphenyldiamine (PPD) (6.4%). Out of total positive cases 27 (21 females and 6 males) had shown strong positive reactions (++). The Nickel Sulfate was responsible in majority of cases (18/27 cases). Farmers had the highest (57.14%) rate of positive allergic reactions followed by housewives (39.62%). According to the regional eczema, patients with persistent and recurrent eczema of different parts of body had the highest rate of positive allergic reactions (47.72%). Almost half of patient with facial eczema (40%) had positive patch test. Conclusion: Larger studies are required in the different parts of the country to find a more accurate data regarding the sensitization pattern in Nepalese population.

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Section: Introductionmentioning

confidence: 99%

Patch Testing In Nepalese Population: A Single Center Study From Kathmandu, Nepal

Paudel

Pun

Parajuli

et al. 2019

Nepal J Dermatol Venereol & Leprol

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“…Proper clinical management relies on differentiating between these two forms of contact dermatitis, and because of overlapping histological features on biopsy, patch testing remains the gold standard for making this determination. [3] While spongiosis is a histological feature that is shared between ACD and ICD, ACD may show greater degrees of intercellular edema, which we would expect to result in a greater degree of HSI detected tissue fluid content present in ACD compared to ICD. [43] In addition, by allowing imaging of large areas at one time, HSI may provide a novel approach towards patch test quantificationthereby standardizing and improving upon the current gold standard.…”

Section: Discussionmentioning

confidence: 91%

“…involves the application and interpretation of a patch test. Patch testing [3] represents the gold standard for both differentiation between ICD and ACD as well as for establishment of the causative agent eliciting the allergic reaction. Patch testing consists of applying multiple substances of interest to distinct areas of unaffected skin.…”

Section: Introductionmentioning

confidence: 99%

Hyperspectral imaging and characterization of allergic contact dermatitis in the short‐wave infrared

Mishra

Shmuylovich

et al. 2020

Journal of Biophotonics

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Short‐wave infrared hyperspectral imaging is applied to diagnose and monitor a case of allergic contact dermatitis (ACD) due to poison ivy exposure in one subject. This approach directly demonstrates increased tissue fluid content in ACD lesional skin with a spectral signature that matches the spectral signature of intradermally injected normal saline. The best contrast between the affected and unaffected skin is achieved through a selection of specific wavelengths at 1070, 1340 and 1605 nm and combining them in a pseudo‐red‐green‐blue color space. An image derived from these wavelengths normalized to unaffected skin defines a “tissue fluid index” that may aid in the quantitative diagnosis and monitoring of ACD. Further clinical testing of this promising approach towards disease detection and monitoring with tissue fluid content quantification is warranted.

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“…Recommendations for amount, however, have also been based on the length of the ribbon of pet. allergen dispensed into the chamber (5 mm), presumably as a more easily reproducible visual approximation of 20 mg . The optimal amount of allergen may also depend on the type of patch test system used .…”

Section: Discussionmentioning

confidence: 99%

Different concentrations and volumes of p‐phenylenediamine in pet. (equivalent doses) are associated with similar patch test outcomes: a pilot study

et al. 2018

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A Practical Guide to Patch Testing

Cited by 51 publications

References 26 publications

Patch Testing In Nepalese Population: A Single Center Study From Kathmandu, Nepal

Patch Testing In Nepalese Population: A Single Center Study From Kathmandu, Nepal

Hyperspectral imaging and characterization of allergic contact dermatitis in the short‐wave infrared

Different concentrations and volumes of p‐phenylenediamine in pet. (equivalent doses) are associated with similar patch test outcomes: a pilot study

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