Different concentrations and volumes of <i>p</i>‐phenylenediamine in pet. (equivalent doses) are associated with similar patch test outcomes: a pilot study

Andersen, F. Alan; Hamann, Carsten R.; Andersen, Klaus Ejner; Hamann, Dathan; Sager, Eric W.

doi:10.1111/cod.12951

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…The elicitation and sensitization capacity depend not only on the concentration, but predominantly on the dose per unit area of allergen delivered to the skin and exposure time 13,21 . In a recent study, good agreement was shown for PPD patch test preparations with equivalent doses of 1.0% and 0.3% pet 22 . If dosed correctly, PPD 1% pet.…”

Section: Discussionmentioning

confidence: 97%

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Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group

et al. 2022

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Background: The textile dye mix (TDM) 6.6% in petrolatum contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of para-phenylenediamine (PPD)-allergic dermatitis patients have been positive to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% because of strong simultaneous reactions to TDM and PPD.Objectives: To study if DO 3 can be excluded from TDM 6.6%.Methods: Patch tests were performed on 1481 dermatitis patients with TDM 6.6%, TDM 7.0% (without DO 3 but the other disperse dyes at 1.0% each), DO 3 1.0%, and PPD 1.0% pet.

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Section: Discussionmentioning

confidence: 97%

“… 13 , 21 In a recent study, good agreement was shown for PPD patch test preparations with equivalent doses of 1.0% and 0.3% pet. 22 If dosed correctly, PPD 1% pet. may be safe to patch test with.…”

Section: Discussionmentioning

confidence: 99%

Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group

et al. 2022

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“…Among the three lowest concentrations tested for PPD and PPD-DHC not presented in this In a recent study, good agreement was shown for PPD patch test preparations with equivalent doses of 1.0% and 0.3% pet. 33 If dosed correctly, PPD 1% pet. may be safe to patch test with.…”

Section: Resultsmentioning

confidence: 99%

“…The elicitation and sensitization capacity depend not only on the concentration, but predominantly on the dose per unit area of allergen delivered to the skin and exposure time . In a recent study, good agreement was shown for PPD patch test preparations with equivalent doses of 1.0% and 0.3% pet . If dosed correctly, PPD 1% pet.…”

Section: Discussionmentioning

confidence: 96%

Twenty‐eight‐day follow‐up of patch test reactions to p‐phenylenediamine and p‐phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group

et al. 2019

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Background: There is an ongoing discussion on whether routinely patch testing with pphenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Lateappearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre-existing sensitization.Objectives: To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD-DHC) in order to characterize reaction patterns concerning time and dose in PPDsensitized individuals.Methods: Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD-DHC in equimolar dilution series. There were then seven follow-up visits over a period of 28 days.Results: Twenty-six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD-DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD-DHC. Conclusion:No late-appearing reactions to PPD or PPD-DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.active sensitization, allergic contact dermatitis, contact allergy, delayed, dilution series, falsenegative reactions, hypersensitivity, late-appearing patch test reactions, PPD

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p-Phenylenediamine induces immediate contact allergy and non-histaminergic itch via MRGPRX2

Che

Gao

et al. 2022

Chemico-Biological Interactions

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Different concentrations and volumes of p‐phenylenediamine in pet. (equivalent doses) are associated with similar patch test outcomes: a pilot study

Abstract: The 88% concordance suggests that dose per unit area is more important in determining reactions to allergens than the excipient volume dispensed. Patch testing with a smaller volume of 1% PPD may be a reasonable alternative to testing with 20 mg of 0.3% PPD.

Cited by 3 publications

References 24 publications

Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group

Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group

Twenty‐eight‐day follow‐up of patch test reactions to p‐phenylenediamine and p‐phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group

p-Phenylenediamine induces immediate contact allergy and non-histaminergic itch via MRGPRX2

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