p-Phenylenediamine induces immediate contact allergy and non-histaminergic itch via MRGPRX2

Che, Delu; Gao, Jiapan; Du, Xueshan; Zheng, Yi; Hou, Yajing; Peng, Bin; Jia, Tao; Geng, Shuang; He, Langchong

doi:10.1016/j.cbi.2021.109751

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…The connection of tryptase and pruritus is further supported by the correlation of blood tryptase reduction in AD patients treated with fexofenadine, an antihistamine, with pruritus improvement [199] (Fig. 3) Enhanced levels of tryptase release and tryptase activity are related to itch in chronic dermatitis, P-phenylenediamine-induced itch, and ovalbumin allergyinduced itch in mice [200][201][202]. Nafamostat mesilate, an oral serin protease inhibitor, inhibits itch-associated responses in mice mainly through the inhibition of mast cell tryptase [203].…”

Section: Tryptasementioning

confidence: 88%

An update on mechanisms of pruritus and their potential treatment in primary cutaneous T-cell lymphoma

Elieh‐Ali‐Komi

Maurer

et al. 2023

Clin Exp Med

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Primary cutaneous T-cell lymphomas (CTCL), which include mycosis fungoides (MF) and Sézary syndrome (SS), are a group of lymphoproliferative disorders characterized by clonal accumulation of neoplastic T-lymphocytes in the skin. Severe pruritus, one of the most common and distressing symptoms in primary CTCL, can significantly impair emotional well-being, physical functioning, and interpersonal relationships, thus greatly reducing quality of life. Unfortunately, effectively managing pruritus remains challenging in CTCL patients as the underlying mechanisms are, as of yet, not fully understood. Previous studies investigating the mechanisms of itch in CTCL have identified several mediators and their corresponding antagonists used for treatment. However, a comprehensive overview of the mediators and receptors contributing to pruritus in primary CTCL is lacking in the current literature. Here, we summarize and review the mediators and receptors that may contribute to pruritus in primary CTCL to explore the mechanisms of CTCL pruritus and identify effective therapeutic targets using the PubMed and Web of Science databases. Studies were included if they described itch mediators and receptors in MF and SS. Overall, the available data suggest that proteases (mainly tryptase), and neuropeptides (particularly Substance P) may be of greatest interest. At the receptor level, cytokine receptors, MRGPRs, and TRP channels are most likely important. Future drug development efforts should concentrate on targeting these mediators and receptors for the treatment of CTCL pruritus.

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Section: Tryptasementioning

confidence: 88%

An update on mechanisms of pruritus and their potential treatment in primary cutaneous T-cell lymphoma

Elieh‐Ali‐Komi

Maurer

et al. 2023

Clin Exp Med

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“…Apart from these common inducers, several studies have analyzed the degranulation effects of antidepressants (clomipramine, paroxetine and desipramine), contrast media (gadopentetate meglumine, iodinated contrast media and iopamidol), p-Phenylenediamine (PPD), P17, morphine derivatives (thebaine and pethidine) and fluoroquinolones and many others. PPD is a component found in hair dyes implicated to induce immediate allergy, acute dermatitis and contact dermatitis 51 . On the other hand, P17 is a short host defense peptide from the ant Tetramonium bicarinatum venom 52 .…”

Section: Inducers and Mediators Release For Lad2 Cellsmentioning

confidence: 99%

Current Utilization Trend of Mast Cell Lines in In Vitro Allergy Research: A Systematic Review

Yip,

Lee,

Kow

et al. 2024

Preprint

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Today in the modern world, allergic diseases, also described as atopic allergies, are classified as a type of multifactorial disorder due to the complex interplay between genetics, environment, and socioeconomic factors that influence the disease’s manifestation, severity, and one’s predisposition to allergic diseases. It is undeniable that many reported studies have pointed out that the mast cell is one of the main key players involved in triggering an allergic reaction. In order to improve our current understanding of the molecular and cellular mechanisms underlying allergy, various mast cell lines have been employed in vitro to study the pathogenesis of allergic diseases for the past decades. However, there is no consensus on many fundamental aspects associated with their use, such as the effects of culture media composition and the type of inducer used for cell degranulation. As the standardization of research protocols and disease models is crucial, we hereby present the outcome of a systematic review of scientific articles that used three major in vitro mast cell lines (HMC-1, LAD2, and RBL-2H3) to study allergy. This systematic review described the cell source, culture conditions, inducers used for degranulation, and mediators released for examination. We hope that the present systematic review may help to standardize the use of in vitro mast cell lines in allergy research and serve as a user’s guide to understand the fundamental aspects of allergy as well to develop an effective allergy therapy in the future for the betterment of human good health and wellbeing.

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Efficient gene transfection of suspension cells by highly branched poly(β-amino ester)

Che

Wang

et al. 2023

Chinese Chemical Letters

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p-Phenylenediamine induces immediate contact allergy and non-histaminergic itch via MRGPRX2

Cited by 5 publications

References 35 publications

An update on mechanisms of pruritus and their potential treatment in primary cutaneous T-cell lymphoma

An update on mechanisms of pruritus and their potential treatment in primary cutaneous T-cell lymphoma

Current Utilization Trend of Mast Cell Lines in In Vitro Allergy Research: A Systematic Review

Efficient gene transfection of suspension cells by highly branched poly(β-amino ester)

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