A practical method for the quantitative assessment of non-enantioselective versus enantioselective interactions encountered in liquid chromatography on brush-type chiral stationary phase

Chiral separation of lenalidomide by liquid chromatography on polysaccharide‐type stationary phases and by capillary electrophoresis using cyclodextrin selectors

“…The classical van't Hoff method, employed in the present study, assumes that enantioselective interactions between the CSP are solely responsible for analyte retention. However, to obtain a more realistic approach, both chiral and nonchiral interactions need to be considered .…”

Covalent Organic Frameworks with Chirality Enriched by Biomolecules for Efficient Chiral Separation

“…[1] Theseparation of racemic compounds has long been of great significance,especially for pharmaceutical and medicinal applications, [2,3] which has spurred continuous interest in the exploration of new materials/approaches for efficient separation of enantiomers. [8][9][10] Biomolecules such as enzymes that are created by nature, [11] can well discriminate enantiomers owing to their natural conformations composed of chiral subunits (that is,amino acids) as well as amphiphilic and zwitterionic features capable of providing specific interactions.T his makes them appealing for chiral separation particularly as chiral stationary phases (CSPs) in chromatography if they can be immobilized on some solidstate materials.H erein, we contribute ag eneral approach to immobilize biomolecules into an ew class of solid-state materials,c ovalent organic frameworks (COFs), and the afforded biomolecules&COFs can serve as versatile and highly efficient CSPs towards various racemates in both normal-phase and reverse-phase high-performance liquid chromatography. [8][9][10] Biomolecules such as enzymes that are created by nature, [11] can well discriminate enantiomers owing to their natural conformations composed of chiral subunits (that is,amino acids) as well as amphiphilic and zwitterionic features capable of providing specific interactions.T his makes them appealing for chiral separation particularly as chiral stationary phases (CSPs) in chromatography if they can be immobilized on some solidstate materials.H erein, we contribute ag eneral approach to immobilize biomolecules into an ew class of solid-state materials,c ovalent organic frameworks (COFs), and the afforded biomolecules&COFs can serve as versatile and highly efficient CSPs towards various racemates in both normal-phase and reverse-phase high-performance liquid chromatography.…”

Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification

“…The (1 S ,2 S )‐2‐aminocyclohexyl phenylcarbamate was obtained according to previous procedure . These four CSPs were obtained by immobilizing their corresponding selectors onto 3‐mercaptopropyl silica with radical thiol‐ene addition reaction . The loading of selectors corresponding to CSP 1, CSP 2, CSP 3 and CSP 4 were 0.125, 0.043, 0.037, 0.031 mmol/g, respectively.…”