Abstract. There is a general lack of understanding of tsunami wave interaction with complex geographies, especially the process of inundation. Numerical simulations are performed to understand the effects of several factors on tsunami wave impact and run-up in the presence of gentle submarine slopes and coastal cliffs, using an in-house code, a constrained interpolation profile (CIP)-based model. The model employs a high-order finite difference method, the CIP method, as the flow solver; utilizes a VOF-type method, the tangent of hyperbola for interface capturing/slope weighting (THINC/SW) scheme, to capture the free surface; and treats the solid boundary by an immersed boundary method. A series of incident waves are arranged to interact with varying coastal geographies. Numerical results are compared with experimental data and good agreement is obtained. The influences of gentle submarine slope, coastal cliff and incident wave height are discussed. It is found that the tsunami amplification factor varying with incident wave is affected by gradient of cliff slope, and the critical value is about 45 • . The run-up on a toe-erosion cliff is smaller than that on a normal cliff. The run-up is also related to the length of a gentle submarine slope with a critical value of about 2.292 m in the present model for most cases. The impact pressure on the cliff is extremely large and concentrated, and the backflow effect is non-negligible. Results of our work are highly precise and helpful in inverting tsunami source and forecasting disaster.