A Pragmatic Approach to Treat Lung Cancer Through Loading Theaflavin -3,3’-Digallate and Epigallocatechin Gallate in Spanlastic

Abstract

Lung cancer has the highest mortality rate as compared to other cancers. The anti-proliferative and antioxidant potential of epigallocatechin gallate (EGCG) and Theaflavin -3,3’-digallate (TF3) can play a major role in treatment if delivered efficiently. To improve the chemical stability and medicinal potential of EGCG and TF3 in the respiratory tract, a spanlastic is developed which is composed of Tween-80, Span-60, and cholesterol which encapsulate EGCG and TF3 inside its vesicular structure and deliver it specifically to the target cancer cells. The cholesterol layer will produce efficient penetration while tween-80 and span-60 will help in easily deformability and lowers the interfacial tension hence, produces a small Z-average diameter which facilitates efficient penetration between layers of cells. The nano-vesicular structure ensures the APIs stability at alkaline pH (7.6) and also increases cellular antioxidant activity and Ferric reducing antioxidant powers values of APIs. Better encapsulation efficiency and safe consideration by MTT assay are major advantages of Spanlastic. The lung cancer cell loses the ability of apoptosis, which can revived with the help of a nano-vesicular system of EGCG and TF3 and in addition, there will be activation of several other properties such as cell arrest, activation of miR-210, suppression of cyclin D1, inhibition of MAPK, ERK, and JAK-STAT at their maximum potential. Furthermore, a special type of spacer and pMDI canister are developed in order to maximize the drug stability and efficiency of its delivery.

Lung Cancer Therapy Using Naturally Occurring Products and Nanotechnology

“…Nanoparticles such as transferosomes are new generation novel drug delivery system which is quite stable at 7.4 pH and its efficacy and drug entrapment potential are better than other conventional nanoparticle systems. These natural products loaded in nanoparticles then loaded in pMDI canisters such as fluorocarbon polymerization (FCP) plasma-coated canisters with a better propellant such as HFA-134a and delivered with the help of spacers can cure lungs cancer economically, efficiently with minimal side effects and it also ensures that the cancer will not reoccur [48].…”

A Descriptive Analysis of Therapeutic Drug Monitoring In India

“…Prothrombin time is an intermediate end objective, whereas renal failure and arrhythmia are toxic end points. The prevention of stroke, pulmonary embolism, and seizure episodes are therapeutic end points [38]. A feasible intermediate end goal may be employed in the absence of readily visible hazardous or therapeutic end points.…”

India’s Growing Demand of Nutraceuticals

“…Comparably, it has been observed that a combination of beta-carotene, lutein, and lycopene carotenoids protects against erythema. Studies on the photoprotective properties of vitamins C and E have shown that they are useful for maintaining skin health [39]. Hydrophilic in nature, vitamin C is often consumed in high quantities through a variety of food products, with the aim of preventing the development of nitrous oxide metabolites that cause cancer.…”