A pragmatic review on the property, role and significance of polymers in treating diabetic foot ulcer

Paul, Esther Jemima; Padmapriya, B.

doi:10.1016/j.matpr.2019.07.406

Cited by 4 publications

(2 citation statements)

References 105 publications

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“…Reports demonstrate that there were 285 million diabetics in 2010, and this is likely to increase to more than 360 million by 2030. The probability of diabetics developing foot ulcers is about 15-25% during their life, and the risk of lower amputations is about 17-40 times higher among diabetics than among their healthy counterparts [11].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model

2021

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Foot ulcers are one of the leading causes of severe and high mortality in diabetics. It is known that wound healing in diabetics is a very complicated process due to the direct severe effect of diabetes mellitus on blood vessels, causing difficulty in wound healing. Many methods of treatment have recently been employed for novel dressings for the promotion of tissue regeneration and rapid wound closure. Combretum molle is composed of chemical compounds, such as lignin, gallic acid, and ellagic acid. Twenty male rats that were 4 months of age were divided into a I-a diabetic foot ulcer group as the control group and a II-a diabetic group (wound + Combretum molle). This study investigated the antioxidant and excellent healing effects of the extract of Combretum molle in repairing skin damaged by diabetes. This was confirmed by elevated antioxidant enzymes in the animals’ tissues in diabetic rats treated with this extract. The recovery of the alterations in the skin layers led to great improvements, which proved the Combretum molle’s promising capacity for wound healing in diabetics with wounds that mimic diabetic foot ulcers. This treatment can be considered a promising opportunity for patients with severe foot ulcers and may open the door to more discoveries about this plant’s medical capabilities.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model

2021

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“…Biocompatible polymer-based wound dressings are commonly used in DFU wound management. Dressings are usually made from either natural polymers, biocompatible synthetic polymers or a combination of natural and synthetic polymers [ 75 , 76 ]. For example, the Integra ® Dermal Regeneration Template consists of a silicone-based outer layer that performs the function of the skin epidermis and an inner layer of bovine tendon collagen and glycosaminoglycan matrix, which provides a scaffold for dermal regeneration [ 77 , 78 ].…”

Section: Treatment Of Diabetic Ulcer/foot Ulcermentioning

confidence: 99%

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

et al. 2020

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Diabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15–25% of DM patients develop DFU at least once in their lifetime. The lack of effective wound dressings and targeted therapy for DFUs often results in prolonged hospitalization and amputations. As the incidence of DM is projected to rise, the demand for specialized DFU wound management will continue to increase. Hence, it is of great interest to improve and develop effective DFU-specific wound dressings and therapies. In the last decade, 3D bioprinting technology has made a great contribution to the healthcare sector, with the development of personalized prosthetics, implants, and bioengineered tissues. In this review, we discuss the challenges faced in DFU wound management and how 3D bioprinting technology can be applied to advance current treatment methods, such as biomanufacturing of composite 3D human skin substitutes for skin grafting and the development of DFU-appropriate wound dressings. Future co-development of 3D bioprinting technologies with novel treatment approaches to mitigate DFU-specific pathophysiological challenges will be key to limiting the healthcare burden associated with the increasing prevalence of DM.

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Evaluation of curcumin release from wound dressing based on gelatin and sturgeon-derived chondroitin sulfate

Soltani

Nazarpak

Zamani

et al. 2023

Materials Today Communications

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A pragmatic review on the property, role and significance of polymers in treating diabetic foot ulcer

Cited by 4 publications

References 105 publications

RETRACTED: Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model

RETRACTED: Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

Evaluation of curcumin release from wound dressing based on gelatin and sturgeon-derived chondroitin sulfate

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