A pre-clinical study to investigate the anti-diabetic potential of p-propoxybenzoic acid as a multi-target inhibitor in streptozotocin-nicotinamide induced type-2 diabetic rats

Biochemical And Triglyceride-Glucose Index (Tyg) Profile In High Doses Streptozotocin-Nicotinamide Produce Diabetes Mellitus In Rats Model

“…STZ dosages ranging from 50 to 65 mg/kg have been found to cause hyperglycemia and partial β cell damage when combined with NICinduced, as shown in T2DM. 20,21,22 High-dose STZ caused severe hyperglycemia and β cell destruction, although the STZ-NA combination reduced glucose tolerance and caused moderate hyperglycemia. The pancreas could still release insulin in the presence of glucose.…”

Emerging paradigms in pre-clinical screening models for drugs acting against diabetes: Delving into complex approaches and advancements

“…It was created with the intention of simulating the development and progressive alterations in metabolism that occur naturally in people with type 2 diabetes. 14 The inspiration for this model came from research that showed a significant impact of a diet high in fat on insulin resistance, which was then followed by hyperinsulinemia 14 However, the percentage of hyperglycemic individuals was unsatisfactory because to hyperinsulinemia. To alter the current direction Sprague-Dawley rats aged 7 weeks were given Streptozotocin (50mg/kg) intravenously.…”

“…To alter the current direction Sprague-Dawley rats aged 7 weeks were given Streptozotocin (50mg/kg) intravenously. 14 The rats had previously been fed a high-fat diet (40 percent of calories as fat) over a two-week period. This particular set of animals had continued to consume a high-fat diet following the Streptozotocin injection.…”

In-Silico and In-Vitro Evaluation of the Anti-Diabetic Activity of Gmelinol

“…Docking can be performed in two interdependent steps: rst is by sampling conformations of the ligand in the active site of the protein and second is by rating of prepared conformations using a scoring function. (12) Alpha amylase is a one of the most important enzymes in the digestive process found in the saliva and pancreatic juice. Alpha amylase activates the process of carbohydrate digestion by hydrolysis of polysaccharides (starch) to disaccharides (maltose), which leads to prevent high postprandial blood glucose.…”