A preclinical evaluation of a programmable CNT membrane device for transdermal nicotine delivery in hairless Guinea pigs

Gulati, Gaurav Kumar; Berger, Lily Rachel; Hinds, Bruce J.

doi:10.1016/j.jconrel.2018.07.003

Cited by 11 publications

(5 citation statements)

References 21 publications

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“…Nicotine was selected as the model drug for this study. Nicotine replacement therapy in the form of transdermal nicotine patches or gums is still widely used for smoking cessation ( 42 ). By monitoring the actual concentration of drug in the skin, the drug delivery, uptake, and metabolic rate for each individual could be assessed.…”

Section: Resultsmentioning

confidence: 99%

Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces

et al. 2021

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Wearable sensing technology is an essential link to future personalized medicine. However, to obtain a complete picture of human health, it is necessary but challenging to track multiple analytes inside the body simultaneously. Here, we present a wearable plasmonic-electronic sensor with “universal” molecular recognition ability. Flexible plasmonic metasurface with surface-enhanced Raman scattering (SERS)–activity is introduced as the fundamental sensing component in a wearable sensor since we solved the technical challenge of maintaining the plasmonic activities of their brittle nanostructures under various deformations. Together with a flexible electronic sweat extraction system, our sensor can noninvasively extract and “fingerprint” analytes inside the body based on their unique SERS spectra. As a proof-of-concept example, we successfully monitored the variation of trace-amounts drugs inside the body and obtained an individual’s drug metabolic profile. Our sensor bridges the existing gap in wearable sensing technology by providing a universal, sensitive molecular tracking means to assess human health.

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Section: Resultsmentioning

confidence: 99%

Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces

et al. 2021

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“…In the study done by Ellis Owusu-Dabo in f the survey population were aware that nicotine gums were banned in Singapore whereas in Our study majority of the population (81%) were not aware that nicotine gums are banned in Haryana [24]. Daniel Du developed a new mint-flavored nicotine gum with modified taste and texture is bioequivalent to the original flavor sugar-free nicotine gum at both the 2 and 4 mg dosage strengths and has a similar safety profile [25]. Some e-cigarette users were dependent on nicotine-containing e but these products were less addictive than tobacco cigarettes.…”

Section: Fig 2 the Pie Chart Depicts The Weather The Participants Smoke Or Know Someone Who Know Someone Who Smokes 30% Say Yes (Red) Whementioning

confidence: 53%

Awareness on Nicotine Gums among Undergraduate Dental Students

Lekha

Ganapathy

Sasanka

2020

JPRI

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Background: The use of tobacco by smokers contributes to the increase of the number of deaths worldwide. According to WHO, nearly 4 million deaths are recorded annually, and 10 million are expected by 2030. Cigarette smoke contains more than 4000 chemicals and the foremost nicotine replacement therapy (NRT) is by chewing gum. The nicotine resin is obtained from a buffered chewing gum base. Those nicotine chewing gums enable nicotine to be immediately absorbed by means of the buccal mucosa, which in turn causes a plasma concentration that is half that produced by way of smoking a cigarette. The gum has numerous strengths and it can be used both after scheduled periods or maybe taken while needed. Purpose: To assess the awareness of nicotine gums among dental students. Materials and Methods: A self-administered questionnaire with 10 questions eliciting responses regarding the awareness of nicotine gums was prepared and circulated to 100 dental students after obtaining informed consent. The responses were collected and analyzed. Results: The data were analyzed using SPSS software version 20 and results were expressed as percentages. 75% of the participants were aware of nicotine gums. 43% said nicotine absorption from the gum is predominant in the mouth and 38 % said it is from gastric mucosa. Conclusion: In summary, nicotine gums awareness among dental students is a moderate fact, and efforts to improve this are required.

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“…A controllable CNT membrane device has been created for the transdermal delivery of nicotine in guinea pigs [ 173 , 174 ]. This CNT membrane device had successfully delivered nicotine fluxes when switched ON and OFF, respectively, according to an in vitro flow-cell test; meanwhile, nicotine flux has been detected through in vivo microdialysis with a membrane implanted in the guinea pig’s skin.…”

Section: Carbon Nanotubes Cntsmentioning

confidence: 99%

“…This CNT membrane device had successfully delivered nicotine fluxes when switched ON and OFF, respectively, according to an in vitro flow-cell test; meanwhile, nicotine flux has been detected through in vivo microdialysis with a membrane implanted in the guinea pig’s skin. Nevertheless, the CNT membrane has low flexibility and tends to flatten the skin contact area which requires applying a small amount of hydroxyethyl cellulose gel on the skin surface underneath the membrane device [ 173 , 174 ].…”

Section: Carbon Nanotubes Cntsmentioning

confidence: 99%

Recent Development of Nanomaterials for Transdermal Drug Delivery

et al. 2023

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Nano-engineered medical products first appeared in the last decade. The current research in this area focuses on developing safe drugs with minimal adverse effects associated with the pharmacologically active cargo. Transdermal drug delivery, an alternative to oral administration, offers patient convenience, avoids first-pass hepatic metabolism, provides local targeting, and reduces effective drug toxicities. Nanomaterials provide alternatives to conventional transdermal drug delivery including patches, gels, sprays, and lotions, but it is crucial to understand the transport mechanisms involved. This article reviews the recent research trends in transdermal drug delivery and emphasizes the mechanisms and nano-formulations currently in vogue.

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A preclinical evaluation of a programmable CNT membrane device for transdermal nicotine delivery in hairless Guinea pigs

Cited by 11 publications

References 21 publications

Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces

Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces

Awareness on Nicotine Gums among Undergraduate Dental Students

Recent Development of Nanomaterials for Transdermal Drug Delivery

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