A preclinical randomized controlled study of ischemia treated with Ginkgo biloba extracts: Are complex components beneficial for treating acute stroke?

Dong, Wen; Zhao, Shunying; Wen, Shaohong; Dong, Chengya; Chen, Qingfang; Gong, Ting; Chen, Wentao; Liu, Wenqian; Mu, Liting; Shan, Honglin; Xie, Xiaoxuan; Liu, Xiangrong

doi:10.1016/j.retram.2020.07.002

Cited by 6 publications

(7 citation statements)

References 40 publications

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“…Flavonoids. Liquid chromatography-mass spectrometry (LC-MS) has been used to identify and separate several flavonoids found in G. biloba [21][22][23][24][25]. To date, 110 [26].…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…In a 3-month controlled, multicenter, double-blinded study, 60 T2DM patients were randomly assigned to one of two classes (GBE 120 mg/day or placebo (starch) 120 mg/day). e administration of GBE dramatically decreased fasting plasma glucose levels, insulin levels, 22 Evidence-Based Complementary and Alternative Medicine blood HbA1c values, waist circumference, body mass index, and visceral adiposity index [180]. Increased very-low-density lipoprotein (VLDL) secretion by liver cells leads to insulin tolerance and hyperlipidemia [59].…”

Section: Clinical Studiesmentioning

confidence: 99%

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Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Noor-E-Tabassum

Das

Lami

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Ginkgo biloba is an ancient plant species that is thought to provide a variety of health benefits to living organisms and contains plenty of bioactive components, making it a chemically diversified plant. G. biloba has been shown to have a variety of medicinal and pharmacological properties, including anticancer, antidementia, antidiabetic, antiobesity, antilipidemic, antimicrobial, antioxidant, antilipid peroxidation, antiplatelet, anti-inflammatory, hepatoprotective, antidepressant, antiaging, immunomodulatory, antihypertensive, and neuroprotective effects and is frequently used to treat neurological, cardiovascular, and respiratory diseases, such as tardive dyskinesia. Therefore, this review described the therapeutic applications of G. biloba. In addition to describing the therapeutic potential, this review also evaluates the chemical constituents, toxicity, adverse effect, synergistic effect, and the clinical studies of this plant which have been utilized for therapeutic benefits but have demonstrated other consequences. The capacity of G. biloba components to act as free radical scavengers is critical, and combining its extract with other plant extracts has been shown to synergistically boost antioxidant properties. G. biloba used long-term or at high doses that resulted in some adverse effects. Severe drug interactions have also been reported in both animals and humans when combined with other medications. The available data established from both preclinical and clinical studies confirm the potential of G. biloba plant extract in various diseases. Besides, the safety and efficacy of G. biloba continue to require verification through additional experimentation to guide medicinal use.

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“…Flavonoids. Liquid chromatography-mass spectrometry (LC-MS) has been used to identify and separate several flavonoids found in G. biloba [21][22][23][24][25]. To date, 110 [26].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Noor-E-Tabassum

Das

Lami

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

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“…We present the following article in accordance with the ARRIVE reporting checklist (available at https://atm.amegroups.com/article/view/10.21037/atm-22-517/rc). (20,21). To confirm the ischemia in mice, regional cerebral blood flow (rCBF) was detected with a laser Doppler flowmetry (RWD Life Science, Shenzhen, China) before and after dMCAO.…”

Section: Original Articlementioning

confidence: 99%

“…The brains were removed quickly and cut into seven 1-mm thick slices. The infarct volume was measured by TTC staining as described previously (20).…”

Section: 35-triphenyltetrazolium Chloride (Ttc) Stainingmentioning

confidence: 99%

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IKKα contributes to ischemia-induced autophagy after acute cerebral ischemic injury

Dong¹,

Chen²,

Zhao³

et al. 2022

Ann Transl Med

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Background: The function of IκB kinase α (IKKα) in the brain is largely unknown. This study examined the effects of IKKα on autophagy after cerebral ischemia.Methods: Permanent distal middle cerebral artery occlusion (dMCAO) was conducted in C57/BL6 mice.Oxygen-glucose deprivation/reperfusion (OGD/R) was performed to mimic ischemia injury in neuro-2A (N2A) cells in vitro. Autophagy activation was assessed by detecting the ratio of microtubule-associated protein 1 light chain 3β (LC3B)-II/LC3B-I and Cyto-ID autophagic fluorescence. The infarct volume was verified by 2,3,5-triphenyltetrazolium chloride (TTC) staining and magnetic resonance imaging (MRI).Neurological functions were evaluated using the modified Garcia test. Cell death after dMCAO was confirmed with terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay. To determine the role of IKKα, small interfering RNA (siRNA) was transfected into N2A cells or injected intracerebroventricularly.Results: IKKα and LC3B II/I expression levels were increased both in OGD/R treated N2A cells and dMCAO mice. Under the same conditions, IKKβ expression was not altered. IKKα siRNA significantly decreased the infarct volume and the apparent diffusion coefficient (ADC) related to brain edema, and promoted the neurological outcomes after dMCAO. Furthermore, inhibition of IKKα attenuated ischemiainduced the conversion of LC3B Ⅰ to LC3B II both in vitro and in vivo. In addition, IKKα siRNA alleviated the formation of autophagic vacuoles and LC3 positive puncta after cerebral ischemia.Conclusions: These findings indicate that IKKα, but not IKKβ, plays a critical role in ischemia-induced autophagy. Inhibition of IKKα protects the brain from ischemia injury and this may have potential benefits in stroke therapy.

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A Novel Extract From Ginkgo biloba Inhibits Neuroinflammation and Maintains White Matter Integrity in Experimental Stroke

et al. 2023

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A preclinical randomized controlled study of ischemia treated with Ginkgo biloba extracts: Are complex components beneficial for treating acute stroke?

Cited by 6 publications

References 40 publications

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

IKKα contributes to ischemia-induced autophagy after acute cerebral ischemic injury

A Novel Extract From Ginkgo biloba Inhibits Neuroinflammation and Maintains White Matter Integrity in Experimental Stroke

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