A Prediction Equation to Assess Resting Energy Expenditure in Japanese Patients with COPD

Abstract

Background: Medical nutrition therapy is important in the management of chronic obstructive pulmonary disease (COPD) patients. Determination of resting energy expenditure is essential to define therapeutic goals for medical nutrition. Previous studies proposed the use of equations to predict resting energy expenditure. No prediction equation is currently available for the Japanese population. The objective of this study was to develop an equation to predict resting energy expenditure in Japanese chronic obstructive pulmonary disease patients. To this end, we investigated clinical variables that correlate with the resting energy expenditure. Methods: This study included 102 COPD patients admitted at the Matsusaka Municipal Hospital Respiratory Center. We measured resting energy expenditure by indirect calorimetry and explored the relationship of resting energy expenditure with clinical variables by univariate and stepwise linear regression analysis. Results: The resting energy expenditure by indirect calorimetry was significantly correlated with fat-free mass, body weight, body mass index, height, gender, and pulmonary function test by univariate analysis. In the stepwise linear regression analysis, the fat-free mass, body weight, and age remained significantly correlated with indirect calorimetry’s resting energy expenditure. The fat-free mass, body weight, and age explained 50.5% of the resting energy expenditure variation. Conclusion: Fat-free mass, body weight, and age were significantly correlated with resting energy expenditure by stepwise linear regression analysis, and they were used to define a predictive equation for Japanese COPD patients.

The Role of Macronutrients in Chronic Obstructive Pulmonary Disease: A Review

“…31,35 Increased metabolic rate in COPD patients results in higher resting energy expenditure (REE) and would influence daily calorie intake. 36 Furthermore, resting carbohydrate oxidation is also found to be elevated in COPD individuals, probably because of increased anaerobic metabolism in a slightly hypoxic state. 37 Determining REE and respiratory quotient (RQ) could measure changes in energy metabolism in individuals.…”

“…37 Determining REE and respiratory quotient (RQ) could measure changes in energy metabolism in individuals. 31,36 RQ measures the body's basal metabolic rate between the volume of CO2 released and the volume of oxygen absorbed. The calculation of RQ is determined by the mixture of the main macronutrient substrates, such as carbohydrates, fats, and proteins.…”