A Prediction Method of Visual Field Sensitivity Using Fundus Autofluorescence Images in Patients With Retinitis Pigmentosa

Abstract

The purpose of this study was to investigate the association between fundus autofluorescence (FAF) and visual field (VF) sensitivities in eyes with retinitis pigmentosa (RP). We also investigated the model we developed to predict VF sensitivity using the FAF ring and its prediction accuracy. METHODS. The training dataset consisted of 51 eyes of 28 patients, and the testing dataset consisted of 42 eyes of 25 patients with RP. VF and FAF measurements were conducted using the Humphrey Field Analyzer (HFA) 10-2 test and Optos. The HFA 10-2 test was divided into three sectors according to the association with the FAF (IN, ON, and OUT). Moreover, concentric curves were drawn at 1-degree intervals outside the FAF ring and OUT was divided into six sectors (from OUT1 to OUT6 toward the periphery). Finally, the total deviation (TD) value was predicted using age and visual acuity (VA) in the whole field, and each of the eight sectors was compared. RESULTS. The TD value decreased significantly from IN, ON, and then toward OUT6. The absolute prediction error with the FAF ring (average, 7.6 dB) was significantly smaller than that without the FAF ring (average, 8.7 dB). The absolute prediction error with the FAF ring was significantly smaller in the central areas (IN, 4.4 dB and ON, 5.3 dB) than those in the peripheral areas (OUT1-6, 6.8-9.1 dB). CONCLUSIONS. VF sensitivity decreases in association with the FAF ring. We developed a model to predict 10-2 VF sensitivity values using the FAF ring, which enabled us to predict 10-2 TD values.

The Association Between the Number of Visual Fields and the Accuracy of Future Prediction in Eyes With Retinitis Pigmentosa

“…35 In contrast, we recently showed that the structural damage in RP, such as fundus auto uorescence, was more accurately measured by VF sensitivity 34,35 using the HFA 10 − 2 test. 36 The current results will be useful when assessing the effects of any candidate treatment on the progression of VF with the HFA 10 − 2 test. In addition, as suggested in a previous study, visual disability is closely associated with HFA 10 − 2 test results, 5 and the current results will be useful when predicting patients' future daily lives using the HFA 10 − 2 test.…”

Detecting Progression of Retinitis Pigmentosa Using the Binomial Pointwise Linear Regression Method

“… 42 For instance, we previously developed a model to predict VF sensitivity measured with the HFA 10-2 test using visual acuity in RP. 19 The study revealed that the model improved when the assessment of the structural damage demonstrated with fundus autofluorescence imaging was combined, implying the limitation of using visual acuity in establishing the severity of disease in RP. The current results suggest that the binomial PLR method will be useful in assessing VF progression with the HFA 10-2 test when evaluating the effects of any candidate treatment.…”

“…One example of this effort is a model to predict the central VF sensitivity from the structural damage demonstrated by fundus autofluorescence imaging in RP. 19 In the current study, we investigated whether binomial PLR is useful in evaluating VF progression in the central 10°, in eyes with RP.…”

Association between the number of visual fields and the accuracy of future prediction in eyes with retinitis pigmentosa

“…35 In contrast, we recently showed that the structural damage in RP, such as fundus autofluorescence, was more accurately measured by VF sensitivity 34 35 using the HFA 10-2 test. 36 The current results will be useful when assessing the effects of any candidate treatment on the progression of VF with the HFA 10-2 test. In addition, as suggested in a previous study, visual disability is closely associated with HFA 10-2 test results, 5 and the current results will be useful when predicting patients' future daily lives using the HFA 10-2 test.…”