A predictive regression model of the obesity-related inflammatory status based on gut microbiota composition

Aranaz, Paula; Ramos-López, Omar; Cuevas-Sierra, Amanda; Riezu-Boj, José Ignacio

doi:10.1038/s41366-021-00904-4

Cited by 52 publications

(35 citation statements)

References 39 publications

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“…In our sample, changes in proinflammatory cytokines were inversely associated with microbial taxa with known anti-inflammatory properties, such as Lachnospiraceae ( 74 , 75 ) and Anaerostipes ( 76 , 77 ). The rise of the former one during short-term weight recovery could be partly responsible for the reduction seen in TNF-α.…”

Section: Discussionmentioning

confidence: 82%

Lower serum levels of IL-1β and IL-6 cytokines in adolescents with anorexia nervosa and their association with gut microbiota in a longitudinal study

et al. 2022

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IntroductionAnorexia nervosa (AN) is an often chronic and debilitating psychiatric disease whose etiology is not completely understood. Recently, a potential role of inflammation has emerged in other psychiatric diseases, such as depression, PTSD and schizophrenia. The first results in adults with AN seemed to confirm a low-grade proinflammatory state until recent studies presented more differential findings. Studying adolescents with a shorter illness duration and fewer confounding factors might help elucidate the role of inflammation in the underlying pathophysiology of AN; however, the few available studies in adolescents remain ambiguous, and no longitudinal data are available in this age range.MethodsWe examined the proinflammatory cytokines Tumor Necrosis Factor-alpha (TNF-α), Interleukin (IL)-1β, IL-6, IL-15, and the cytokine-receptor IL-6 Receptor alpha (IL-6 Rα) in the serum of twenty-two hospitalized female adolescent patients with AN longitudinally at admission and discharge and compared their results to nineteen healthy controls (HC). We also collected clinical data and stool samples that were analyzed with 16S rRNA amplicon sequencing to explore potential influencing factors of cytokine changes.ResultsTNF-α serum levels were significantly elevated in patients with AN at admission, while IL-1β and IL-6 levels were lower at admission and discharge than in HC. After treatment, we also found significantly elevated levels of IL-6 Rα compared to HC, while IL-15 did not show significant changes. Exploratory analyses revealed positive associations of cytokine and genus-level changes between admission and discharge for IL-1β (Bacteroides) and IL-15 (Romboutsia), and negative associations for IL-15 (Anaerostipes) and TNF-α (uncultured Lachnospiraceae).ConclusionWe confirmed a previous finding of elevated levels of TNF-α also in adolescents with AN; however, the reduced IL-1β and IL-6 levels differed from the mostly increased levels found in adults. A mixed pro- and anti-inflammatory state appears to be present in adolescents, potentially due to their shorter illness duration. The gut microbiota, with its regulatory function on cytokine production, might play a role in mediating these inflammatory processes in AN and could offer targets for new therapeutic approaches.

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Section: Discussionmentioning

confidence: 82%

Lower serum levels of IL-1β and IL-6 cytokines in adolescents with anorexia nervosa and their association with gut microbiota in a longitudinal study

et al. 2022

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“…The relative abundance of Gemmiger in the anxiety and depression group was similar to that in another study related to diarrhea-predominant irritable bowel syndrome (2.4%) (35). In addition, Aranaz's study showed that the abundance of Gemmiger decreased in subjects with a higher inflammatory index (36). Similar results were found in a systematic review in which a reduced abundance of Ruminococcus was observed in depressed people (37).…”

Section: Discussionsupporting

confidence: 81%

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“…These families have been no associated with weight loss in the scientific literature, although Catabacteriaceae has been associated with low grade of inflammation [58]. Clostridium genus has been found to correlate with weight loss in an adolescent population [59], although its role as a biomarker for weight loss in women is not described in the bibliography.…”

Section: Discussionmentioning

confidence: 99%

A weight-loss model based on baseline microbiota and genetic scores for selection of dietary treatments in overweight and obese population

Cuevas-Sierra¹,

Milagro²,

Guruceaga³

et al. 2022

Clinical Nutrition

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A predictive regression model of the obesity-related inflammatory status based on gut microbiota composition

Cited by 52 publications

References 39 publications

Lower serum levels of IL-1β and IL-6 cytokines in adolescents with anorexia nervosa and their association with gut microbiota in a longitudinal study

Lower serum levels of IL-1β and IL-6 cytokines in adolescents with anorexia nervosa and their association with gut microbiota in a longitudinal study

Data_Sheet_1.PDF

A weight-loss model based on baseline microbiota and genetic scores for selection of dietary treatments in overweight and obese population

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