A Preliminary Ethno-medical Survey of Plants Used in the Traditional Management of Cancer and Related Diseases amongst Tarok People of Plateau State, North-Central Nigeria

Dafam, D.G.; Agunu, A; Ibrahim, H.; Ajima, Ukpe; Ohemu, T.L.; Okwori, Victoria A.; Kagaru, D. C.; Ilyas, Najma

doi:10.9734/ejmp/2016/29281

Cited by 4 publications

(3 citation statements)

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“…The need for natural alternative medicines has thus been desirable. Anticancer effect of L. taraxacifolia had been purported in ethnomedicinal reports without concrete scientific data [ 38 ]. Thomford et al [ 30 ], in an in vitro study, reported the anticancer effect of L. taraxacifolia .…”

Section: Resultsmentioning

confidence: 99%

The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey

Adinortey

Sarfo

Kwarteng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. The plant, commonly found in West Africa, is used in the management of many diseases including cardiovascular, respiratory, haematological, endocrine, and metabolic diseases in Ghana, Nigeria, Benin, Serra Leone, and Senegal. This piece provides comprehensive and updated information on the traditional uses, phytochemical constituents, and pharmacological and toxicological information available on Launaea taraxacifolia to support its medicinal uses and also unearth knowledge gaps for future studies. An electronic literature search using search engines, namely, Google Scholar, ScienceDirect, and PubMed, was carried out to obtain information on the plant. Both common and scientific names of the plant were used as keywords for the search process. This paper captured information on Launaea taraxacifolia from 1985 to 2018. The search revealed that the leaves of the plant possess nutritional/pharmacological effects on diseases such as diabetes mellitus, hypertension, cancer, malaria, bacterial infections, and arthritis. The leaf has been shown to be a rich source of phytoconstituents such as flavonoids, phenolic acids, tannins, alkaloids, glycosides, coumarins, triterpenoids, ascorbic acid, lycopene, and β-carotene. Also, isolated phytoconstituents as well as the safety profile of the plant have been documented. This review on Launaea taraxacifolia has provided a one-stop documentation of information in support of the several purported ethnopharmacological uses of the plant. It also reveals information gaps such as the need to research into its pharmacokinetics, interactions with drugs of importance, and its development into a plant-based drug in order to expand its clinical use.

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Section: Resultsmentioning

confidence: 99%

The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey

Adinortey

Sarfo

Kwarteng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Our findings revealed that C. africana was one of the most frequently used medicinal plants for the treatment of cancer. Other recent ethnobotanical surveys from the northern part of Nigeria also documented the use of the stem bark of the plant for the treatment of cancer (Dafam et al, ; Ngulde, Sandabe, & Hussaini, ). Therefore, the present study was designed to investigate the cytotoxicity of the methanol (MeOH) extract of the stem bark of C. africana , its solid‐phase extraction (SPE) and fractions and isolated compounds against four human carcinoma cell lines: the breast (MCF7), the liver (HepG2), the lung (A549), the prostate (PC3), and the immortalized human prostatic epithelial cells (PNT‐2) using the in vitro 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazoliumbromide (MTT) viability assay.…”

Section: Introductionmentioning

confidence: 94%

Resveratrol derivatives from Commiphora africana (A. Rich.) Endl. display cytotoxicity and selectivity against several human cancer cell lines

Segun

Ogbole

Ismail

et al. 2018

Phytotherapy Research

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Commiphora africana (A. Rich.) Endl. (Burseraceae) is a medicinal plant widely used in Nigerian ethnomedicine. The in vitro cytotoxicity of the stem bark extract of C. africana and isolated cytotoxic compounds was investigated. Three resveratrol derivatives: (E)-resveratrol 3-O-rutinoside (1), 5-methoxy-(E)-resveratrol 3-O-rutinoside (2), and pinostilbene (3), together with 3-hydroxy-5-methoxybenzoic acid (4) were isolated from the methanol fraction of C. africana. Their structures were determined by extensive analysis of their HREIMS and NMR spectra. The cytotoxicity of the isolated compounds against four human carcinoma cells was determined using the MTT assay. Compound 1 displayed the highest antiproliferative effect on the cell lines, with IC 50 values of 16.80, 21.74, 17.89, and 17.44 μM, against MCF7, A549, PC3, and HepG2 human cancer cell lines, respectively. In addition, compounds 1-3 showed low toxicity against normal human prostate cell line, with selectivity indices greater than five across the carcinoma cells, indicating that the compounds possess potential in the development of low-toxicity chemotherapeutic agents. These results support the traditional use of this plant in the treatment of cancer.

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“…Plants have at all times remained connected in our life both as a source of vegetables or medicine (Dafam et al, 2016). Studies have shown that vegetables offer a noble source of remedy against numerous diseases and illnesses (Dansi et al, 2008).…”

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confidence: 99%

Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on Rodents

Uwaya,

Bello,

Aikpitanyi

2023

jasem

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Euphorbia hirta and lactuca virosa are used to treat various ailment traditionally. This study aims at evaluating the antitussive, expectorant and analgesic effects of aqueous extracts of di-herbal formulation of Euphobia hirta and Lactuca virosa leaf. Citric acid induced, ammonia induced cough and phenol red dye secretion models were used. Hot plate and acetic acid induced writhing were used for analgesia. Combined 100mg/kg Euphorbia hirta and 50mg/kg lactuca virosa, 100mg/kg Euphorbia hirta and 100mg/kg lactuca virosa, 100mg/kg lactuca virosa only and 25 mg/kg of codeine phosphate reduces the number of cough bouts in the citric acid induced cough (P<0.05) compared to control. Combined 50mg/kg Euphorbia hirta and 100mg/kg lactuca virosa,100mg/kg Euphorbia hirta, 100mg/kg lactuca virosa and codeine phosphate reduces the number of cough bouts in the ammonia induced cough (P<0.001; P<0.0001) compared to the control. Combined 50mg/kg Euphorbia hirta and 100mg/kg lactuca virosa, 100mg/kg Euphorbia hirta and 50mg/kg lactuca virosa, 100mg/kg Euphorbia hirta and 100mg/kg lactuca virosa and 15mg/kg of Bromo-hexane increases the secretion of dye (P<0.0001; p<0.05) compared to control in phenol red dye secretion in mice. 100mg/kg Euphorbia hirta and 50mg/kg lactuca virosa,100mg/kg of Euphorbia hirta and 100mg/kg lactuca virosa and 3mg/kg Pentazocin increases the latency of pain threshold of mice (P<0.05). All the doses of the extract including 3mg/kg pentazocin increases the latency to pain threshold in the mice (P<0.001) after 2 hours. All the doses of the extract including aspirin reduces number of writhing (P<0.01). Euphorbia hirta and lactuca virosa has antitussive, expectorant and analgesic properties.

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A Preliminary Ethno-medical Survey of Plants Used in the Traditional Management of Cancer and Related Diseases amongst Tarok People of Plateau State, North-Central Nigeria

Cited by 4 publications

References 0 publications

The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey

The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey

Resveratrol derivatives from Commiphora africana (A. Rich.) Endl. display cytotoxicity and selectivity against several human cancer cell lines

Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on Rodents

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