A preliminary microarray assay of the mi<scp>RNA</scp> expression signatures in buccal mucosa of oral submucous fibrosis patients

Chickooree, Daminee; Zhu, Keke; Ram, Vahsish; Wu, Hanjiang; He, Zhi Jing; Zhang, Sheng

doi:10.1111/jop.12431

Cited by 37 publications

(27 citation statements)

References 13 publications

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“…However, up to now, only a few of miRNAs have been reported to participate in the occurrence and development process of OSF. Chickooree et al performed a preliminary microarray analysis of miRNA expression profile to filter out 11 differential expressed miRNA in OSF (Chickooree et al, ; Zheng et al, ). Zheng et al found that miR‐203 could inhibit the arecoline‐induced epithelial–mesenchymal transition in OSF (Zheng et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Oral submucous fibrosis is a well-known fibrosis lesion in oral mucosa, which carries a significantly high transformation rate of 3%-19% to oral squamous cell carcinoma (OSCC) (Ila, Girish, & Paturu, 2016;Ranganathan & Kavitha, 2011). nary microarray analysis of miRNA expression profile to filter out 11 differential expressed miRNA in OSF (Chickooree et al, 2016;Zheng et al, 2015). Zheng et al found that miR-203 could inhibit the arecoline-induced epithelial-mesenchymal transition in OSF (Zheng et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Pathogenesis investigation of miR‐199‐5p in oral submucous fibrosis based on bioinformatics analysis

Yuan

Zeng

et al. 2018

Oral Diseases

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Objectives Fibrosis diseases are one of the leading causes of suffering and death. However, no systematic investigation has been carried out on fibrosis‐related genes. Materials and Methods By querying PubMed using keywords “fibrosis” and “gene” or “protein,” we identified fibrosis‐related genes in the last decade. Bioinformatics analysis was performed by MAS 3.0 software. Key miRNA was selected to assess its relationship with oral submucous fibrosis (OSF) and fibroblast functions. Results A total of 1,310 genes related to fibrosis were identified. TGF‐β1, CTGF, MMP9, HSP47, and S1P were found to be associated with mainly fibrotic organs. In total, 244 cellular components terms, 595 molecular function terms, 1,816 cellular component terms, and 136 KEGG pathway annotations were predicted. miR‐199‐5p was selected as the key miRNA, which has higher level in OSF. Upregulated miR‐199‐5p was significantly related to OSF duration and OSF histological grade (p = 0.028 and 0.012, respectively). Overexpressive miR‐199‐5p reduced proliferation and induced apoptosis in buccal fibroblasts. Additionally, expression levels of collagen I (COL I) and III (COL III) were promoted by overexpressive miR‐199‐5p in buccal fibroblasts. Conclusion These results indicate that fibrosis‐related genes are related to a series of complex mechanisms. The characteristics of miR‐199‐5p may supply important clues for developing therapeutic strategy for OSF.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pathogenesis investigation of miR‐199‐5p in oral submucous fibrosis based on bioinformatics analysis

Yuan

Zeng

et al. 2018

Oral Diseases

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“…It has been shown that miR-4792 is downregulated in nasopharyngeal carcinoma, uterine leiomyoma, during submucosal brosis and in glioblastoma-in ltrating CD14 + cells. In contrast, miR-4792 is upregulated in glioma microvesicles [13][14][15][16][17]. Our previous studies have shown that the expression of miR-4792 increases in THP-1 cells infected with C.neoformans (WM148) ( Fig.…”

Section: Mir-4792 and Egfr Expression In Bv2 Cells Induced By C Neofmentioning

confidence: 90%

MiR-4792 regulates inflammatory responses in Cryptococcus neoformans infected microglia

Chen

Yao

Wang

et al. 2020

Preprint

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Background: Investigating the factors that influence inflammatory response of microglial cells is important to understand the pathogenesis of cryptococcal meningitis (CM). MicroRNA (miRNA) have been shown to play an important role in inducing host defenses and activating immune response in the process of microbial infection; however, the regulatory mechanisms of miRNAs in cryptococcal meningitis are poorly defined. In our previous analysis, we assessed the miRNA profiles of BV2 cells following Cryptococcus neoformans (C. neoformans) infection. In this study, we characterized the expression of miR-4792 in CM patients to further our understanding of the host response to pathogen infections. Results: miR-4792 was downregulated in BV2 cells infected with C. neoformans while its target gene EGFR was upregulated. Infected cells with up-regulated miR-4792 exhibited a trend towards decreased EGFR transcript expression, reduced MAPK signaling and a decreased secretion of inflammatory cytokines. Afterantifungal treatment in cryptococcal meningitis patients, the levels of miR-4792 in the CSF significantly increased, while the expression of EGFR significantly decreased. Conclusion: This study identified that miR-4792 and its target gene EGFR regulate the secretion of inflammatory cytokines in BV2 cells infected with C. neoformans. This furthers our knowledge of the inflammatoryresponses to fungal infections in the CNS.

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“…It has been shown that miR-4792 is downregulated in nasopharyngeal carcinoma, uterine leiomyoma, during submucosal fibrosis and in glioblastoma-infiltrating CD14 + cells. In contrast, miR-4792 is upregulated in glioma microvesicles [13][14][15][16][17]. Our previous studies have shown that the expression of miR-4792 increases in THP-1 cells infected with C.neoformans (WM148) ( Fig.…”

Section: Mir-4792 and Egfr Expression In Bv2 Cells Induced By C Neofmentioning

confidence: 90%

MiR-4792 regulates inflammatory responses in Cryptococcus neoformans infected microglia

Chen

Yao

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Investigating the factors that influence inflammatory response of microglial cells is important to understand the pathogenesis of cryptococcal meningitis (CM). MicroRNA (miRNA) have been shown to play an important role in inducing host defenses and activating immune response in the process of microbial infection; however, the regulatory mechanisms of miRNAs in cryptococcal meningitis are poorly defined. In our previous analysis, we assessed the miRNA profiles of BV2 cells following Cryptococcus neoformans (C. neoformans) infection. In this study, we characterized the expression of miR-4792 in CM patients to further our understanding of the host response to pathogen infections.Results: miR-4792 was downregulated in BV2 cells infected with C. neoformans while its target gene EGFR was upregulated. Infected cells with up-regulated miR-4792 exhibited decreased EGFR expression, reduced MAPK signaling and a decreased secretion of inflammatory cytokines. Following antifungal treatment in cryptococcal meningitis patients, the levels of miR-4792 in the CSF significantly increased, while the expression of EGFR significantly decreased.Conclusion: This study identified that miR-4792 and its target EGFR regulate the secretion of inflammatory cytokines in C. neoformans infected BV2 cells. This furthers our knowledge of the host immune responses to fungal infections in the CNS.

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A preliminary microarray assay of the miRNA expression signatures in buccal mucosa of oral submucous fibrosis patients

Cited by 37 publications

References 13 publications

Pathogenesis investigation of miR‐199‐5p in oral submucous fibrosis based on bioinformatics analysis

Pathogenesis investigation of miR‐199‐5p in oral submucous fibrosis based on bioinformatics analysis

MiR-4792 regulates inflammatory responses in Cryptococcus neoformans infected microglia

MiR-4792 regulates inflammatory responses in Cryptococcus neoformans infected microglia

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