A Preliminary Study of the Effect of Hyperadrenocorticism on Calcium and Phosphate Concentrations, Parathyroid Hormone and Markers of Bone Turnover in Dogs

Mooney, Carmel T.; Shiel, Robert E.; Sekiya, Mary; Dunning, Mark; Gunn, Eilidh

doi:10.3389/fvets.2020.00311

Cited by 3 publications

(17 citation statements)

References 51 publications

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“…Hyperphosphatemia was described in hypercortisolemic dogs in the present study, as had been reported in previous studies 3,4,6,7,13 . The reasons behind this finding are not clear.…”

Section: Discussionsupporting

confidence: 74%

“…Hypercalciuria occurred in the hypercortisolemic dogs of the present study, supporting the role of abnormal calcium balance in the development of adrenal secondary hyperparathyroidism. Sustained hypercalciuria could stimulate PTH secretion by inducing a mild negative calcium balance despite that the circulating calcium concentrations remained largely unaffected, as reported in this and in previous studies 5,6,25 . Moreover, hyperphosphatemia stimulates the parathyroid glands to produce PTH independently of changes in serum calcium concentrations 25 .…”

Section: Discussionsupporting

confidence: 69%

“…In both these groups, the iPTH is approximately 50% higher than wPTH (median values in dogs with NOHC are 87.2 and 43.74 pg/mL, respectively), with a strong correlation between them. Thus, the measurement of either provides similar information 6 . Overall, the occurrence of adrenal secondary hyperparathyroidism in hypercortisolemic dogs could be supported by all these studies.…”

Section: Discussionsupporting

confidence: 58%

“…Despite decreased bone mineral density is described in dogs with NOHC compared to healthy dogs, there is no evidence of bone metabolism alterations in dogs with hypercortisolism based on the evaluation of some markers of bone formation and resorption. 6,23 Alternately, increased intestinal absorption could compensate for increased urinary calcium excretion, but it seems less likely considering that hypercortisolism decreases intestinal calcium absorption in humans. 18 The influence of hypercortisolism on intestinal calcium absorption in dogs was evaluated neither in the present nor in other studies.…”

Section: Discussionmentioning

confidence: 99%

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Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

Corsini

Dondi

Serio

et al. 2021

Veterinary Internal Medicne

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Background: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. Objectives: To evaluate circulating concentrations of whole parathormone (wPTH), 25-hydroxyvitamin D (25-(OH)D), calcitriol, and fibroblast growth factor-23 (FGF-23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. Animals: Twenty-three client-owned dogs with NOHC, and 12 client or staff-owned healthy dogs. Methods: Prospective cross-sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25-(OH)D, calcitriol and FGF-23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs.Results: Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03-2.44 vs 0.15%, range, 0.06-0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7-490 vs 24.6 pg/mL, range, 5.5-56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25-(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF-23 concentrations than controls (316.6 pg/mL, range, 120.8-575.6 vs 448.7 pg/mL, range, 244.8-753; P = .03).Conclusions and Clinical Importance: Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism.

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“…Hyperphosphatemia was described in hypercortisolemic dogs in the present study, as had been reported in previous studies 3,4,6,7,13 . The reasons behind this finding are not clear.…”

Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

Corsini

Dondi

Serio

et al. 2021

Veterinary Internal Medicne

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“…PTH and FGF-23 analysis was carried out at the Royal Veterinary College, United Kingdom. PTH concentrations were quantified using a human total intact PTH immunoradiometric assay (Scantibodies Laboratory Inc., Santee, CA, USA) validated and previously used with canine samples [ 27 , 37 , 38 , 39 ]. FGF-23 concentrations were quantified using a human sandwich ELISA (Kainos Laboratories Inc., Tokyo, Japan) validated and previously used with canine samples [ 27 , 40 ].…”

Section: Methodsmentioning

confidence: 99%

No Observed Adverse Effects on Health Were Detected in Adult Beagle Dogs When Fed a High-Calcium Diet for 40 Weeks

Atwal¹,

Stockman²,

Gilham³

et al. 2021

Animals

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The implications of long-term high calcium (Ca) intake are well documented in growing dogs and in adult dogs of large breed size, however, the consequences on other breeds and breed sizes are yet to be determined. Eighteen neutered adult beagles, nine males and nine females aged 1.4–4.4 years, were randomized to control or test diets providing in g∙4184 kJ−1 (1000 kcal−1): 1.44 and 7.19 total Ca balanced with 1.05 and 4.25 total phosphorus, respectively, for 40 weeks. Health parameters, ultrasound scans, radiographs, glomerular filtration rate, and mineral balance were measured at eight-week intervals. All dogs remained healthy with no measured evidence of orthopedic, urinary, or renal disease. The test diet resulted in a 5.2 fold increase in fecal Ca excretion. Apparent Ca digestibility (%) and Ca balance (g/d) did not significantly (p > 0.05) change from baseline in the test diet group, although dogs displayed a positive Ca balance (maximum at week 8, 1.11 g/d with 95% CI (0.41, 1.80)) before a neutral Ca balance was restored at week 32. Despite an initial positive Ca balance, we can conclude that no measurable adverse health effects were observed as a result of the test diet fed in this study in beagles over a period of 40 weeks.

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Endocrine System

Rosol,

Brändli-Baiocco,

Hoenerhoff

et al. 2024

Haschek and Rousseaux' S Handbook of Toxicologic Pathology

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A Preliminary Study of the Effect of Hyperadrenocorticism on Calcium and Phosphate Concentrations, Parathyroid Hormone and Markers of Bone Turnover in Dogs

Cited by 3 publications

References 51 publications

Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

No Observed Adverse Effects on Health Were Detected in Adult Beagle Dogs When Fed a High-Calcium Diet for 40 Weeks

Endocrine System

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