A preliminary study of the effects of sub thalamic nucleus (STN) deep brain stimulation (DBS) on voice and speech characteristics in Parkinson's Disease (PD)

Hoffman-Ruddy, Bari; Schulz, Geralyn M.; Vitek, J.; Evatt, Marion

doi:10.3109/02699200109167638

Cited by 26 publications

(19 citation statements)

References 5 publications

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“…This study, therefore, corroborates the findings of previous studies reporting treatment outcomes of STN-DBS in terms of reducing the monopitch quality of PD patients' speech (Alatri et al, 2008;Dromey et al, 2000;Gentil et al, 2001;Hoffman-Ruddy et al, 2001). For cZi-DBS, no such positive effect on pitch variability was observed in our data.…”

Section: Discussionsupporting

confidence: 92%

“…Improvements have been observed in overall voice quality in terms of acoustic harmonic-to noise ratios (Van Lancker Sidtis, Rogers, Godier, Tagliati, & Sidtis, 2010), pitch range and voice stability (Alatri et al, 2008;Dromey, Kumar, Lang, & Lozano, 2000;Gentil, Chauvin, Pinto, Pollak, & Benabid, 2001;Hoffman-Ruddy, Schulz, Vitek, & Evatt, 2001). …”

Section: Introductionmentioning

confidence: 99%

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Pitch Variability in Patients With Parkinson’s Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus

Karlsson

Olofsson

Blomstedt

et al. 2013

J Speech Lang Hear Res

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Pitch Variability in Patients With Parkinson’s Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus

Karlsson

Olofsson

Blomstedt

et al. 2013

J Speech Lang Hear Res

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“…De Letter, Santens, De Bodt et al (2007) reported improved respiratory measures following levodopa administration in all of 25 PD subjects tested. A single case study reported improved respiration and phonation time in DBS on (Hoffman-Ruddy et al, 2001) and longer phonation time was seen in a group of seven DBS patients (Rousseaux, Krystkowiak, Kozlowski, et al, 2004). Levodopa was observed to upscale the overall levels of vocal amplitude and tempo (Ho et al, 2008), presumably benefiting from enhanced respiratory function.…”

Section: Discussionmentioning

confidence: 98%

Voice and Fluency Changes as a Function of Speech Task and Deep Brain Stimulation

Sidtis

Rogers

Godier

et al. 2010

J Speech Lang Hear Res

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Speaking, which naturally occurs in different modes or “tasks” such as conversation and repetition, relies on intact basal ganglia nuclei. Recent studies suggest that voice and fluency parameters are differentially affected by speech task. This study examines the effects of subcortical functionality on voice and fluency, comparing measures obtained from spontaneous and matched repeated speech samples. Parkinson subjects who are being treated with bilateral deep brain stimulation (DBS) of the subthalamic nuclei (STN) were tested with stimulators ON and OFF. Results indicated that a voice measure, harmonic to noise ratio, is improved in repetition and in DBS-ON, and that dysfluencies are more plentiful in conversation with little or variable influence of DBS condition. These findings suggest that voice and fluency are differentially affected by DBS treatment and that task conditions, interacting with subcortical functionality, influence motor speech performance.

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“…DBS treatment involves using a unilateral or bilateral stimulator to target electrical signals to the STN, which is believed to disrupt brain signaling responsible for the motor and vocal impairment symptoms of PD. [1,10,11] DBS has been shown to alleviate motor symptoms, but its effects on voice are less clear. [12–14] Recent studies focusing on the use of levodopa in conjunction with DBS of the STN have argued that DBS of the STN affects neuronal structures involved in voice that are not affected by levodopa, namely non-dopaminergic lesions.…”

Section: Introductionmentioning

confidence: 99%

“…[5,16] These studies have applied acoustic perturbation analysis to evaluate the effects of DBS and levodopa. [11,18,19]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effects of Deep Brain Stimulation of the Subthalamic Nucleus and Levodopa Treatment on Parkinsonian Voice Using Perturbation, Nonlinear Dynamic, and Perceptual Analysis

Zhou

Lee²,

Wang³

et al. 2009

Folia Phoniatr Logop

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Background/Aims: To quantify aperiodic phonation, nonlinear dynamic methods of acoustic voice analysis, such as correlation dimension, have been shown to be useful. The purpose of this study is to evaluate the validity of nonlinear dynamic analysis as a voice analysis tool for the effects of deep brain stimulation (DBS) and levodopa on patients with Parkinson’s disease (PD). Methods: In this study, the effects of DBS and levodopa treatment on patients with PD were measured using perturbation, nonlinear dynamic, and perceptual analysis. Nineteen PD patients that received bilateral (n = 9), left (n = 7), or right (n = 3) DBS performed sustained vowel phonations, which were recorded before and after medication with the stimulator off and on. Recordings were also taken of 10 PD patients who did not receive DBS surgery before and after medication to provide a baseline. Results: A mixed two-way ANOVA (surgery, medication) generated significant positive treatment effects of DBS only in mean log-transformed D₂, which was supported by mean log-transformed shimmer, vF₀ (variability in fundamental frequency), and vAm (peak-to-peak amplitude variation). Conclusion: These findings may indicate the validity of nonlinear dynamic analysis as a complement to perceptual analysis in clinical PD voice studies.

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A preliminary study of the effects of sub thalamic nucleus (STN) deep brain stimulation (DBS) on voice and speech characteristics in Parkinson's Disease (PD)

Cited by 26 publications

References 5 publications

Pitch Variability in Patients With Parkinson’s Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus

Pitch Variability in Patients With Parkinson’s Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus

Voice and Fluency Changes as a Function of Speech Task and Deep Brain Stimulation

Evaluation of the Effects of Deep Brain Stimulation of the Subthalamic Nucleus and Levodopa Treatment on Parkinsonian Voice Using Perturbation, Nonlinear Dynamic, and Perceptual Analysis

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