A Preliminary Study on Magnetic Fields Effects on Stem Cell Differentiation

Miskon, Azizi; Uslama, Jatendra

doi:10.1007/978-3-642-21729-6_197

Cited by 6 publications

(2 citation statements)

References 60 publications

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“…Nevertheless, some concerns regarding their use at a therapeutic level have been raised (D'Angelo et al, 2015). These predominantly pertain to the use of specific amplitudes, frequencies, and exposure times (Miskon and Uslama, 2011).…”

Section: Electromagnetic Fieldsmentioning

confidence: 99%

Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?

Isakovic

Šerer

Barišić

et al. 2023

Front. Bioeng. Biotechnol.

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Neurological disorders are recognized as major causes of death and disability worldwide. Because of this, they represent one of the largest public health challenges. With awareness of the massive burden associated with these disorders, came the recognition that treatment options were disproportionately scarce and, oftentimes, ineffective. To address these problems, modern research is increasingly looking into novel, more effective methods to treat neurological patients; one of which is cell-based therapies. In this review, we present a critical analysis of the features, challenges, and prospects of one of the stem cell types that can be employed to treat numerous neurological disorders—mesenchymal stem cells (MSCs). Despite the fact that several studies have already established the safety of MSC-based treatment approaches, there are still some reservations within the field regarding their immunocompatibility, heterogeneity, stemness stability, and a range of adverse effects—one of which is their tumor-promoting ability. We additionally examine MSCs’ mechanisms of action with respect to in vitro and in vivo research as well as detail the findings of past and ongoing clinical trials for Parkinson’s and Alzheimer’s disease, ischemic stroke, glioblastoma multiforme, and multiple sclerosis. Finally, this review discusses prospects for MSC-based therapeutics in the form of biomaterials, as well as the use of electromagnetic fields to enhance MSCs’ proliferation and differentiation into neuronal cells.

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Section: Electromagnetic Fieldsmentioning

confidence: 99%

Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?

Isakovic

Šerer

Barišić

et al. 2023

Front. Bioeng. Biotechnol.

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show abstract

“…Because of the negative connotations revolving around EMF and the effects of radiation, concerns have been raised regarding its usage at the therapeutic level (D'Angelo et al, 2015). To determine whether EMF is either dangerous or harmless, certain parameters such as amplitude, frequency, and exposure time are needed to be considered (Carpenter and Ayrapetyan, 1994;Miskon and Uslama, 2011). Two studies have shown that EMF exposure within a specified range does not cause any cytotoxic effects in MSCs.…”

Section: Cytotoxic and Genotoxic Effects Of Emf On Mscsmentioning

confidence: 99%

Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios

Hamid

Sarmadi

Prasad

et al. 2022

J. Zhejiang Univ. Sci. B

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Mesenchymal stem/stromal cell (MSC)-based therapy has been regarded as one of the most revolutionary breakthroughs in the history of modern medicine owing to its myriad of immunoregulatory and regenerative properties. With the rapid progress in the fields of osteo- and musculoskeletal therapies, the demand for MSC-based treatment modalities is becoming increasingly prominent. In this endeavor, researchers around the world have devised new and innovative techniques to support the proliferation of MSCs while minimizing the loss of hallmark features of stem cells. One such example is electromagnetic field (EMF) exposure, which is an alternative approach with promising potential. In this review, we present a critical discourse on the efficiency, practicability, and limitations of some of the relevant methods, with insurmountable evidence backing the implementation of EMF as a feasible strategy for the clinically relevant expansion of MSCs.

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Smart Biopolymer Scaffolds Based on Hyaluronic Acid and Carbonyl Iron Microparticles: 3D Printing, Magneto-Responsive, and Cytotoxicity Study

Gorgol,

Mrlík,

Mikulka

et al. 2024

ACS Appl. Bio Mater.

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This study deals with utilization of the hyaluronic acid (HA) and carbonyl iron (CI) microparticles to fabricate the magneto-responsive hydrogel scaffolds that can provide triggered functionality upon application of an external magnetic field. The various combinations of the HA and CI were investigated from the rheological and viscoelastic point of view to clearly show promising behavior in connection to 3D printing. Furthermore, the swelling capabilities with water diffusion kinetics were also elucidated. Magneto-responsive performance of bulk hydrogels and their noncytotoxic nature were investigated,, and all hydrogels showed cell viability in the range 75−85%. The 3D printing of such developed systems was successful, and fundamental characterization of the scaffolds morphology (SEM and CT) has been presented. The magnetic activity of the final scaffolds was confirmed at a very low magnetic field strength of 140 kA/m, and such a scaffold also provides very good biocompatibility with NIH/3T3 fibroblasts.

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A Preliminary Study on Magnetic Fields Effects on Stem Cell Differentiation

Cited by 6 publications

References 60 publications

Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?

Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?

Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios

Smart Biopolymer Scaffolds Based on Hyaluronic Acid and Carbonyl Iron Microparticles: 3D Printing, Magneto-Responsive, and Cytotoxicity Study

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