A Preliminary Study on Treatment of Human Herpes Simplex Keratitis with an Interferon Inducer

Evaluation of Topical Polyinosinic Acid-Polycytidylic Acid in Treatment of Localized Herpes Zoster in Children with Cancer: a Randomized, Double-Blind Controlled Study

“…The remaining 12 patients had a maximum of 10 lesions appearing for 1 to 3 days. Of the 13 patients with skin generalization, 1 To our knowledge, no other trials of poly(I:C) in treatment of herpes zoster have been reported; however, this agent has been used to treat herpes simplex keratitis (9). The results of this study, unlike ours, suggest a beneficial effect by the drug, although the authors caution against definitive conclusions.…”

“…In a preliminary report, Guerra et al (9) indicate a favorable response to poly(I:C) by 17 of 21 patients with herpes simplex keratitis. Hill et al (10), by contrast, could not distinguish any significant effects of poly(I:C) administered intranasally to volunteers with rhinovirus 13 or type A2 influenza virus.…”

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

“…Sixty-three trials enrolled patients with dendritic epithelial keratitis, including two trials that may have also enrolled other types of HSV epithelial keratitis (Chen 2008; Yang 2000); 38 trials enrolled participants with either dendritic or geographic epithelial keratitis (Blake 1977; Carmassi 1993; Colin 1981; Colin 1984; Colin 1997a; Colin 1997b; Colin 2007a; Colin 2007b; Coster 1976; Coster 1980; Daniel 1972; de Koning 1983; Denis 1983; Fulhorst 1972; Genée 1987; Guerra 1979; Haut 1983; Hoang-Xuan 1984; Huang 2008a; Jackson 1984; Kitano 1985; Laibson 1964; Li 2008; Markham 1977; Maychuk 1988; McCulley 1982; McGill 1974; Patterson 1967a; Pavan-Langston 1976; Pavan-Langston 1981; Serifoglu 1987; Sugar 1980; Sundmacher 1984a; Van Bijsterveld 1989; Wellings 1972; Yeakley 1981; Young 1982); two trials were restricted to patients with geographic keratitis (Collum 1985; Coster 1979); and three trials provided insufficient information to ensure that all participants had dendritic epithelial keratitis (Burns 1963; Davidson 1964; Klauber 1982). Of studies that enrolled eyes with either dendritic or geographic epithelial keratitis, 24 trials provided information on the numbers with dendritic epithelial keratitis (1469) and with geographic epithelial keratitis (326), yielding a median dendritic to geographic epithelial keratitis ratio of 5.0:1 (interquartile range, 3.5:1 to 9.5:1).…”

“… 1 Thirteen of 46 randomised, double-masked trials are not tabulated because two-week outcome data were not provided (Burns 1963; Wang 2004) or because comparative interventions not listed in this table were studied (Cellini 1994; Colin 1984; Coster 1977a; Guerra 1979; Parlato 1985; Sundmacher 1976b; Sundmacher 1978a; Sundmacher 1984a; Sundmacher 1985; Uchida 1981; Uchida 1982) NA: not applicable (single study available for evaluation) …”

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

“… 1 Thirteen of 46 randomised, double-masked trials are not tabulated because two-week outcome data were not provided (Burns 1963; Wang 2004) or because comparative interventions not listed in this table were studied (Cellini 1994; Colin 1984; Coster 1977a; Guerra 1979; Parlato 1985; Sundmacher 1976b; Sundmacher 1978a; Sundmacher 1984a; Sundmacher 1985; Uchida 1981; Uchida 1982). …”