Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

Abstract

Background-Eye disease due to herpes simplex virus (HSV) commonly presents as epithelial keratitis.Objectives-To compare the relative effectiveness of antiviral agents, interferon, and corneal débridement in the treatment of acute HSV epithelial keratitis. Search methods-We searched CENTRAL (

Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland

“…In addition to the natural clearance barriers limiting drug absorption, treatment of acute ocular surface disorders such as keratitis [3] as well as chronic diseases including glaucoma [4] may require addition of eye drops up to hourly, challenging patient compliance [5]. In many cases, ocular diseases such as scleritis [6] and fungal [7], bacterial and viral keratitis [8] must be treated systemically through oral or intravenous drug delivery to get enough drug to the target area, resulting in significant drug exposure at non-target sites. To overcome these challenges, various strategies, including invasive and noninvasive approaches [9, 10], have been developed to increase ocular bioavailability, improve precorneal residence time, and prolong therapeutic efficacy after topical application.…”

Common eye infections

“…21 The treatment is aciclovir ointment five times daily for 14 days. [23][24][25] Stromal herpes simplex keratitis presents with haze or opacity of the stroma, with or without ulceration, scarring or vascularisation. Endothelial keratitis is characterised by keratitic precipitates on the endothelium and corneal oedema.…”

The three faces of herpes simplex epithelial keratitis: a steroid-induced situation

“…There were no clinical or serological features suggesting an HIV infection or other systemic immunocompromised states. It is important to note here that if the patient had displayed systemic immunocompromise, it may have been useful to add oral Aciclovir to the treatment 3. We also recommend HIV testing for all such patients.…”