A presentation of the differences between the sheep and goat genetic maps

Maddox, J F

doi:10.1051/gse:2004030

Cited by 7 publications

(9 citation statements)

References 17 publications

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“…Overall, then, this marsupial species has the shortest recombinational map, and by inference the lowest recombination rate, yet described for any vertebrate; and, unlike other vertebrates, M. domestica females have much less recombination than males over most of the genome, a situation also observed in the linkage map of the distantly related model kangaroo species, M. eugenii, but in no other vertebrate for which extensive mapping data are available. (Potential exceptions reported in sheep (Maddox 2005) and Japanese flounder (Coimbra et al 2003) remain provisional. In sheep, peculiarities of the sex ratio of the mapping panel may have artificially expanded the estimate of male map length (Maddox et al 2001, p 1285, andpersonal communication), while in flounder the genetically unusual cross and substantially incomplete map of the single male parent suggest that the observed level of heterochiasmy may not be representative of the overall genome or the species in general.…”

Section: Discussionmentioning

confidence: 89%

“…Eutherian linkage maps, for example, range from õ1400 centiMorgans (cM) in laboratory mice (Rhodes et al 1998) to more than 3500 cM in sheep (Maddox 2005) and humans (Kong et al 2004). The Ffirst-generation_ M. domestica sexaveraged linkage map, comprising 80 loci distributed among eight autosomal linkage groups, is only 633 cM long, excluding three unmapped X-linked loci (Samollow et al 2004).…”

Section: Introductionmentioning

confidence: 99%

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A microsatellite-based, physically anchored linkage map for the gray, short-tailed Opossum (Monodelphis domestica)

et al. 2007

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The genome of the gray, short-tailed opossum, Monodelphis domestica, will be the first of any marsupial to be fully sequenced. The utility of this sequence will be greatly enhanced by construction and integration of detailed genetic and physical maps. Therefore, it is important to verify the unusual recombinational characteristics that were suggested by the 'first-generation' M. domestica linkage map; specifically, very low levels of recombination and severely reduced female recombination, both of which are contrary to patterns in other vertebrates. We constructed a new linkage map based on a different genetic cross, using a new and much larger set of map markers, and physically anchored and oriented the linkage groups onto chromosomes via fluorescence in-situ hybridization mapping. This map includes 150 loci in eight autosomal linkage groups corresponding to the eight autosome pairs, and spans 86-89% of the autosomal genome. The sex-averaged autosomal map covers 715 cM, with a full-length estimate of 866 cM; the shortest full-length linkage map reported for any vertebrate. The sex-specific maps confirmed severely reduced female recombination in all linkage groups, and an overall F/M map ratio = 0.54. These results greatly extend earlier findings, and provide an improved microsatellite-based linkage map for this species.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

A microsatellite-based, physically anchored linkage map for the gray, short-tailed Opossum (Monodelphis domestica)

et al. 2007

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“…Several reports of linkage between genes and QTL with wool production traits are available for sheep (Parsons et al, 1994;Rogers et al, 1994;Allain et al, 1998Allain et al, , 2006Beh et al, 2001;Ponz et al, 2001;Purvis and Franklin, 2005;Bidinost et al, 2008). Because of the homology between sheep and goat maps (Crawford et al, 1995;Maddox, 2005), putative QTL affecting fleece traits found in the Angora goat on CHI1, CHI5 and CHI19 could be related to the keratin-associated protein (KAP) and keratin (KRT) gene family as pointed out by McLaren et al (1997). In sheep, on chromosome 1 (OAR1), OAR3 and OAR11 several high glycine-tyrosine keratin-associated proteins (KAP6.1, KAP7, KAP8, KAP1 and KAP3) and keratin genes (KRT1, KRT2, KRT2.13 and KRT2.10) were mapped by McLaren et al (1997).…”

Section: Discussionmentioning

confidence: 99%

Chromosomal segments underlying quantitative trait loci for mohair production in Angora goats

Cano¹,

Debenedetti

Abad

et al. 2009

Anim. Genet. Resour. Inf.

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This study reports the results obtained in the search of chromosomal regions affecting fleece traits in a population of Angora goats in the Argentinean Patagonia. Six hundred thirty-four offspring from 14 parental half-sib families were used. Nine phenotypic fleece traits were recorded at 4 and 11 months of age. A genome examination using 85 informative molecular markers was conducted. A linkage analysis was performed using a regression interval analysis. Our study identified 10 genomic regions affecting the average fibre diameter, coefficient of variation of the average fibre diameter, percentage of fibres with diameters over 30 µm, greasy fleece weight, staple length, average curvature of fibres, percentage of continuous medullated fibres and percentage of kemp fibres located on five goat chromosomes (1, 2, 5, 13 and 19). These results show that the average size of the quantitative trait loci effect was 1.6 phenotypic standard deviations for different traits and families. The aims of quantitative trait loci detection is the potential use of these molecular markers to increase accuracy in predicting the genetic merit of breeding and its implementation in animal breeding schemes through marker-assisted selection. RésuméDans cette étude, on signale les résultats obtenus dans la recherche des régions chromosomiques relatives aux caractéristiques de la toison des chèvres angora dans la Patagonie argentine. On a utilisé 634 descendants de 14 familles à descendance uniparentale et enregistré neuf caractères phénotypiques de la toison à 4 et 11 mois. Un examen du génome a été entrepris en utilisant 85 marqueurs moléculaires informatifs. L'analyse du groupe de liaison a été effectuée en utilisant une analyse de l'intervalle de régression. Notre étude a identifié 10 régions génomiques qui affectent le diamètre moyen de la fibre, le coefficient de variation du diamètre moyen de la fibre, le pourcentage de fibre ayant un diamètre supérieur à 30 µm, le poids de la laine en suint, la longueur de la fibre, la courbure moyenne de la fibre, le pourcentage de fibres médullaires continues et le pourcentage de fibre de jarre située sur cinq chromosomes de chèvre (1, 2, 5, 13 et 19). Ces résultats indiquent que la taille moyenne de l'effet QTL était des déviations phénotypiques standard de 1,6 pour les différents caractères et familles. Le but de la détection des QTL est l'utilisation potentielle de ces marqueurs moléculaires en vue d'accroître la précision dans la prévision de la valeur génétique de la sélection et sa mise en oeuvre dans les programmes de sélection animale par le biais de la sélection assistée par marqueurs. Mots-clés: chèvres Angora, mohair, loci à effets quantitatifsResumen En este estudio, informamos sobre los resultados obtenidos en la búsqueda de regiones cromosómicas que afectan a las características del vellón en una población de cabras de Angora en la Patagonia Argentina. Se utilizaron seiscientos treinta y cuatro crías de 14 familias parentales de medios hermanos. A la edad de 4 meses y de 11 meses, se re...

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“…A Bonferroni correction (derivative-free restricted maximum likelihood, DFREML) was used to analyze the relationship between GH gene and litter size with animal models (Meyer and Kirkpatrick, 2005). Pedigrees of base population animals were traced back three (Matou) or four (Boer) generations, in order to create the numerator relationship matrix.…”

Section: Methodsmentioning

confidence: 99%

The association of two single nucleotide polymorphisms (SNPs) in growth hormone (GH) gene with litter size and superovulation response in goat-breeds

et al. 2010

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Two active mutations (A 781 G and A 1575 G) in growth hormone (GH) gene, and their associations with litter size (LS), were investigated in both a high prolificacy (Matou, n = 182) and a low prolificacy breed (Boer, n = 352) by using the PCR-RFLP method. Superovulation experiments were designed in 57 dams, in order to evaluate the effect of different genotypes of the GH gene on superovulation response. Two genotypes (AA and AB, CC and CD) in each mutation were detected in these two goat breeds. Neither BB nor DD homozygous genotypes were observed. The genotypic frequencies of AB and CC were significantly higher than those of AA and CD. In the third parity, Matou dams with AB or CC genotypes had significantly larger litter sizes than those with AA and CD (p < 0.05). On combining the two loci, both Matou and Boer dams with ABCD genotype had the largest litter sizes when compared to the other genotypes (p < 0.05). When undergoing like superovulation treatments, a significantly higher number of corpora lutea and ova, with a lower incidence of ovarian cysts, were harvested in the AB and CC genotypes than in AA and CD. These results show that the two loci of GH gene are highly associated with abundant prolificacy and superovulation response in goat breeds.

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A presentation of the differences between the sheep and goat genetic maps

Cited by 7 publications

References 17 publications

A microsatellite-based, physically anchored linkage map for the gray, short-tailed Opossum (Monodelphis domestica)

A microsatellite-based, physically anchored linkage map for the gray, short-tailed Opossum (Monodelphis domestica)

Chromosomal segments underlying quantitative trait loci for mohair production in Angora goats

The association of two single nucleotide polymorphisms (SNPs) in growth hormone (GH) gene with litter size and superovulation response in goat-breeds

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