A preventive effect of the combination of albendazole and pomegranate peel aqueous extract treatment in cystic echinococcosis mice model: An alternative approach

Labsi, Moussa; Soufli, Imene; Khelifi, Lila; Amir, Zine-Charaf; Touil-Boukoffa, Chafia

doi:10.1016/j.actatropica.2019.105050

Cited by 27 publications

(14 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result also conforms with Zhang and Jing [33] who reported that ABZ decreased TNF-α in mice infected with alveolar echinococcosis. However, our results differ from those of Labsi et al [41] who declared an increase in expression of TNF-α in hepatocytes and Kupffer cells in liver sections of mice from ABZ treated group. Also in contrast to our results for treatment by NSO in G4, Sheir et al [42] reported that NSO increased TNF-α in mice infected with S. mansoni.…”

Section: Discussioncontrasting

confidence: 99%

Efficacy of Nigella sativa oil and its chitosan loaded nanoparticles on experimental cystic echinoncoccosis with immunological assessment

Kishik

Nagati

Hayawan

et al. 2020

Parasitologists United Journal

View full text Add to dashboard Cite

Background: Cystic echinococcosis is a frequent worldwide disease. Surgery is the main policy of treatment. The benzimidazoles are the drugs of choice as adjuvant therapy besides surgery, but they have some drawbacks, so there is a pressing need to develop other safe and cheap drugs such as an herbal extract. Objectives: To increase the efficacy of Nigella sativa oil (NSO) administered either as monotherapy or combined with albendazole, and using chitosan nanoparticles as a drug delivery system for both drugs. Material and Methods: E. granulosus protoscoleces were obtained by aseptic puncture of hydatid cysts. Mice infected by intraperitoneal inoculation with nearly 1000 protoscoleces per mouse were subdivided into 7 groups: G2, infected non-treated; G3, treated with albendazole; G4, treated with NSO; G5, treated with NSO and albendazole; G6, treated with albendazole loaded on chitosan nanoparticles; G7, treated with NSO loaded on chitosan nanoparticles; G8, treated with albendazole and NSO loaded on chitosan nanoparticles. G1 included the non-infected, non-treated control mice. Serum was collected for biochemical and serological assay. NO was measured according to nitric oxide assay colorimetric kit. The systemic level of TNF-α and IL-5 was determined in the plasma of mice using commercial enzyme-linked immunosorbent assay kits. Results: The results revealed that a significant increase of IL-5 occurred in all treated groups to reach the highest value in G8. There was a significant decrease of TNF-α in all treated groups in comparison to G1 and G2 (P<0.001). Mean level of nitric oxide (NO) was significantly increased in groups loaded on chitosan nanoparticles in comparison to G2. Conclusion: Nigella sativa oil showed a promising effect on CE when used alone or in combination with albendazole and its effect was augmented when loaded on chitosan nanoparticles.Nanotechnology and treatment of echinoncoccosis Kishik et al.,

show abstract

Section: Discussioncontrasting

confidence: 99%

Efficacy of Nigella sativa oil and its chitosan loaded nanoparticles on experimental cystic echinoncoccosis with immunological assessment

Kishik

Nagati

Hayawan

et al. 2020

Parasitologists United Journal

View full text Add to dashboard Cite

show abstract

“…Labsi and coworkers reported that the combination of pomegranate peel aqueous and albendazole showed more hydatid cyst growth inhibition; the histological structure of liver improvement and significant iNOS, TNF-α, NF-κβ, vimentin, CD68 decrease expression compared with albendazole-treated groups in mice infected with E. granulosus [54].…”

Section: Therapeuticsmentioning

confidence: 99%

Mechanism of Fibrosis Induced by Echinococcus spp.

et al. 2019

View full text Add to dashboard Cite

Infection with Echinococcus spp. causes fibrosis in various vital organs, including the liver and lungs. Hepatic fibrosis is a pathological feature of Echinococcus infection that destroys normal liver tissue, leading to jaundice, cholecystitis, portal hypertension, etc. Severe Echinococcus multilocularis infections lead to liver failure and hepatic encephalopathy. The formation of peripheral fiberboards around the metacestode is a major reason as to why antiparasitic drugs fail to be effectively transported to the lesion site. Studies on the mechanism of hepatic fibrosis caused by Echinococcus are important for treatment in patients. Recent studies have focused on miRNA and TGF-β. More recent findings have focused on the generation of collagen fibers around the metacestode. In this review paper we focus on the mechanism by which the Echinococcus parasite induces fibrosis in liver and some other organs in intermediate hosts—animals as well as human beings.

show abstract

“…• Pomegranate peel aqueous extract (PGE) in combination with albendazole has anti-hydating and anti-inflammatory effects in vivo, in mice infected with Echinococcus granulosus [55]. The researchers consider that PGE has a significant additive anti-hydatid effect and is beneficial in the preventive treatment of recurrences [55].…”

Section: The Current State Of Knowledgementioning

confidence: 99%

Medical Treatment of Cystic Echinococcosis

Dumitru¹

2020

Overview on Echinococcosis

View full text Add to dashboard Cite

Medical treatment in cystic echinococcosis is limited; albendazole remains the gold treatment for patients with low hydatid cysts or those with inoperable echinococcosis. Due to uncommon side effects, administration may be continuous (cycles of 28 days with a break of 14 days between courses) as well as discontinuous over long periods of time. In recent years, there have been many concerns for the testing of various substances and drugs against Echinococcus granulosus, both in vitro and in vivo, on the animal model, but the results have not been satisfactory. New clinical trials are required, as well as the development of an effective vaccine to limit the spread of echinococcosis in endemic areas.

show abstract

A preventive effect of the combination of albendazole and pomegranate peel aqueous extract treatment in cystic echinococcosis mice model: An alternative approach

Cited by 27 publications

References 40 publications

Efficacy of Nigella sativa oil and its chitosan loaded nanoparticles on experimental cystic echinoncoccosis with immunological assessment

Efficacy of Nigella sativa oil and its chitosan loaded nanoparticles on experimental cystic echinoncoccosis with immunological assessment

Mechanism of Fibrosis Induced by Echinococcus spp.

Medical Treatment of Cystic Echinococcosis

Contact Info

Product

Resources

About